Find hotels in Downtown South San Francisco, San Francisco

Start date: Check-in selected.
To Date
End date: Check-out
  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Downtown South San Francisco hotels

La Quinta Inn & Suites by Wyndham San Francisco Airport N

La Quinta Inn & Suites by Wyndham San Francisco Airport N
3.0 star property
Downtown South San Francisco
8.0 out of 10, Very Good, (2021)
"Clean room, staff were friendly, breakfast was good, parking was good, overall we're satisfied!"
Canada
Edna
The price is NT$3,186
NT$3,742 total
includes taxes & fees
Jan 2 - 2026/1/3
La Quinta Inn & Suites by Wyndham San Francisco Airport N

Airport Inn

Airport Inn
2.0 star property
Downtown South San Francisco
8.8 out of 10, Excellent, (972)
"Very clean room, friendly staff and secure parking."
United States
Christopher
The price is NT$3,118
NT$3,657 total
includes taxes & fees
Dec 19 - Dec 20
Airport Inn

Miller Apartments

Miller Apartments
2.0 star property
Downtown South San Francisco
7.4 out of 10, Good, (15)
"Own bedroom was quiet and tidy, shared bathroom clean and tidy, good communication "
Australia
Kasey
The price is NT$1,890
NT$4,596 total
includes taxes & fees
Dec 19 - Dec 20
Miller Apartments

Inn By The SFO

Inn By The SFO
2.0 star property
Downtown South San Francisco
7.8 out of 10, Good, (1000)
"Excellent property!!! I would definitely recommend!!! Great stay!!! "
United States
David
Inn By The SFO

The Westin San Francisco Airport

The Westin San Francisco Airport
4.0 star property
6.8 km from Downtown South San Francisco
8.8 out of 10, Excellent, (2035)
"Room great, location and shuttle were excellent Enjoyed 2 restaurants and Starbucks on site. "
United States
Robert
The price is NT$3,241
NT$4,648 total
includes taxes & fees
Dec 20 - Dec 21
The Westin San Francisco Airport

Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf
4.0 star property
16.7 km from Downtown South San Francisco
9.0 out of 10, Wonderful, (7213)
"Good location and great hotel to stay, the bed was very comfortable and the breakfast was good with lots of options! "
Canada
Veronica
The price is NT$3,857
NT$5,837 total
includes taxes & fees
Dec 21 - Dec 22
Hotel Riu Plaza Fisherman's Wharf

Hotel Caza Fisherman's Wharf

Hotel Caza Fisherman's Wharf
4.0 star property
16.7 km from Downtown South San Francisco
9.0 out of 10, Wonderful, (3840)
"Excellent stay and great location! "
United States
CHRISTINE
The price is NT$3,827
NT$5,949 total
includes taxes & fees
Dec 21 - Dec 22
Hotel Caza Fisherman's Wharf

Hilton San Francisco Financial District

Hilton San Francisco Financial District
4.0 star property
15.4 km from Downtown South San Francisco
8.8 out of 10, Excellent, (2139)
"Great hotel "
United States
Tanya
The price is NT$3,523
NT$4,147 total
includes taxes & fees
Dec 22 - Dec 23
Hilton San Francisco Financial District

Hotel 1550

Hotel 1550
3.5 star property
5.1 km from Downtown South San Francisco
9.0 out of 10, Wonderful, (1045)
"Great front desk experience, nice room and very convenient to the airport. "
United States
Elmaz
The price is NT$3,197
NT$3,784 total
includes taxes & fees
Jan 6 - 2026/1/7
Hotel 1550

Hotel Aluxor SFO

Hotel Aluxor SFO
2.5 star property
3.8 km from Downtown South San Francisco
8.6 out of 10, Excellent, (2574)
"Very clean, great staff, easy access."
United States
Nicole
Hotel Aluxor SFO

Hilton San Francisco Airport Bayfront

Hilton San Francisco Airport Bayfront
4.0 star property
9.9 km from Downtown South San Francisco
8.6 out of 10, Excellent, (2731)
"Nice airport hotel…staff was great, breakfast was amazing "
United States
Lynne
The price is NT$2,944
NT$3,347 total
includes taxes & fees
Dec 30 - Dec 31
Hilton San Francisco Airport Bayfront

Handlery Union Square Hotel

Handlery Union Square Hotel
3.5 star property
14.5 km from Downtown South San Francisco
8.8 out of 10, Excellent, (2807)
"Clean hotel, great location, kind staff! "
United States
Felix
The price is NT$3,779
NT$4,448 total
includes taxes & fees
Dec 19 - Dec 20
Handlery Union Square Hotel

DoubleTree by Hilton San Francisco Airport

DoubleTree by Hilton San Francisco Airport
4.0 star property
9.3 km from Downtown South San Francisco
8.6 out of 10, Excellent, (1364)
"Nice hotel and area "
Canada
Robert
The price is NT$3,022
NT$3,435 total
includes taxes & fees
Dec 19 - Dec 20
DoubleTree by Hilton San Francisco Airport

Aloft San Francisco Airport

Aloft San Francisco Airport
3.0 star property
6.9 km from Downtown South San Francisco
9.0 out of 10, Wonderful, (2229)
"All good, friendly staff, spotless room. "
United States
Michael
The price is NT$3,159
NT$3,631 total
includes taxes & fees
Dec 29 - Dec 30
Aloft San Francisco Airport

Club Quarters Hotel in San Francisco

Club Quarters Hotel in San Francisco
4.0 star property
15.4 km from Downtown South San Francisco
8.8 out of 10, Excellent, (2809)
"Clean and comfortable room, good staff, great location. "
United Kingdom
David
The price is NT$3,158
NT$3,717 total
includes taxes & fees
Dec 21 - Dec 22
Club Quarters Hotel in San Francisco

Holiday Inn Express and Suites Fisherman's Wharf by IHG

Holiday Inn Express and Suites Fisherman's Wharf by IHG
3.0 star property
16.6 km from Downtown South San Francisco
9.0 out of 10, Wonderful, (2226)
"The room was nice and clean. The staff were very friendly! We enjoyed our stay!"
United States
Theresa
The price is NT$3,307
NT$4,837 total
includes taxes & fees
Dec 24 - Dec 25
Holiday Inn Express and Suites Fisherman's Wharf by IHG

Hotel Aura SFO

Hotel Aura SFO
3.0 star property
4.4 km from Downtown South San Francisco
9.0 out of 10, Wonderful, (2548)
"Perfect hotel, clean room and friendly staffs "
United States
Tam Giao
The price is NT$2,976
NT$3,573 total
includes taxes & fees
Dec 20 - Dec 21
Hotel Aura SFO

Chancellor Hotel on Union Square

Chancellor Hotel on Union Square
3.5 star property
14.7 km from Downtown South San Francisco
9.4 out of 10, Exceptional, (3058)
"Best location, friendly staff, had a wonderful time stayed! "
United States
Kalinda
The price is NT$2,385
NT$2,818 total
includes taxes & fees
Dec 23 - Dec 24
Chancellor Hotel on Union Square

King George Hotel

King George Hotel
3.0 star property
14.5 km from Downtown South San Francisco
8.6 out of 10, Excellent, (2101)
"Great place!"
United States
Troy
The price is NT$2,664
NT$3,608 total
includes taxes & fees
Dec 21 - Dec 22
King George Hotel

Best Western Inn & Suites San Mateo - San Francisco Airport

Best Western Inn & Suites San Mateo - San Francisco Airport
2.5 star property
11.8 km from Downtown South San Francisco
8.8 out of 10, Excellent, (1262)
"Good place to stay, clean and good breakfast."
United States
Xiaohong
The price is NT$2,976
NT$3,421 total
includes taxes & fees
Dec 21 - Dec 22
Best Western Inn & Suites San Mateo - San Francisco Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Downtown South San Francisco

Find the best Downtown South San Francisco areas and neighborhoods for the activities you enjoy most.

Union Square

Major tourist destination in downtown San Francisco, Union Square boasts shopping, hotels, and theaters. Explore department stores, boutiques, and galleries, or catch a performance at various theaters. Enjoy the Dewey Monument and stunning views from nearby hotels. Easily accessible via cable car lines, buses, and subway systems.

Downtown San Francisco

Serving as San Francisco's central business district, this area boasts Northern California's two tallest buildings, the Salesforce Tower and Transamerica Pyramid. Explore shopping malls like the Embarcadero Center and enjoy parks such as Sue Biermann Park, all easily accessible via Muni bus and rail lines.

Fisherman's Wharf

Discover Pier 39, Ghirardelli Square, and the San Francisco Maritime National Historical Park in this bustling tourist hotspot. Savor seafood at family-owned restaurants and explore the sea lion colony, while enjoying convenient cable car access.

South of Market

From baseball games to top-notch art exhibits, find endless entertainment in one of San Francisco’s fastest-growing neighborhoods.

Nob Hill

Luxury hotels, historic mansions, and Michelin-starred restaurants abound in this upscale area. Explore Union Square shopping district, Grace Cathedral, and the SF Masonic Auditorium for a taste of culture and history.

Top Downtown South San Francisco Hotel Reviews

Frequently asked questions

What's it like in Downtown South San Francisco?
You'll be sure to have fun visiting South San Francisco's Downtown South San Francisco neighborhood.
What's a favorite place to stay in Downtown South San Francisco?
Based on Expedia customer reviews, La Quinta Inn & Suites by Wyndham San Francisco Airport N is a highly ranked property in Downtown South San Francisco. This hotel offers free breakfast and an outdoor pool. Other favorite options in the area include Airport Inn and Inn By The SFO.
How many hotels will I find in the Downtown South San Francisco area?
When you want to kick up your feet after a day of exploring the sights in South San Francisco, you can choose from 13 Expedia hotels and other accommodations in Downtown South San Francisco.
If I need to cancel my hotel reservation in Downtown South San Francisco, will I receive a refund?
Yes, the majority of room reservations are refundable provided that you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of the scheduled arrival. If you have a reservation that's non-refundable, it might still be possible to cancel it and be given a refund within a 24-hour period of your booking. Enter dates in and click on "Search", then you can use the "fully refundable" filter to get the best deals available in Downtown South San Francisco.
Where can I learn more about changing or cancelling my trip to Downtown South San Francisco?
To find more details about picking new dates or cancelling your trip to Downtown South San Francisco, head over to our customer service page.
What can I see and do in this South San Francisco neighborhood?
See's Candies, Cinemark Century at Tanforan, and K1 Speed are just a few of the places to visit in and around Downtown South San Francisco. K1 Speed San Francisco and The Shops at Tanforan are also worth a visit when you're out sightseeing in South San Francisco.

Explore a world of travel with Expedia