Find hotels in Downtown South San Francisco, San Francisco

Start date: Check-in selected.
To Date
End date: Check-out

    Change your mind

    Book hotels with free cancellation

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Oct 28 - Oct 29
Tomorrow
Oct 29 - Oct 30
This weekend
Oct 31 - Nov 2
Next weekend
Nov 7 - Nov 9

Filter by

Guest rating
Guest rating
Star rating

Discover Downtown South San Francisco hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Exterior
La Quinta Inn & Suites by Wyndham San Francisco Airport N
La Quinta Inn & Suites by Wyndham San Francisco Airport N
3.0 star property
8.0 out of 10, Very Good, (2031)
"The staff at check in and check out were VERY friendly!! I appreciated that it was close to the airport and a Denny’s for lunch!!"
United States
Deborah
The price is NT$3,107
NT$3,650 total
includes taxes & fees
Nov 16 - Nov 17
La Quinta Inn & Suites by Wyndham San Francisco Airport N
Interior detail
Airport Inn
Airport Inn
2.0 star property
8.8 out of 10, Excellent, (966)
"I was surprised by how friendly the front desk guy was when I checked in after midnight, and also by how clean the room was, for the price I would say this is unbeatable for the area, I will be back."
United States
Todd
The price is NT$3,041
NT$3,566 total
includes taxes & fees
Nov 1 - Nov 2
Airport Inn
Lobby
Inn By The SFO
Inn By The SFO
2.0 star property
7.8 out of 10, Good, (1002)
"Room is spacious"
Canada
leo
Inn By The SFO
Fridge, microwave, coffee/tea maker, dining tables
Miller Apartments
Miller Apartments
2.0 star property
7.4 out of 10, Good, (15)
"Ty"
United States
Mariah
The price is NT$1,920
NT$4,571 total
includes taxes & fees
Nov 1 - Nov 2
Miller Apartments
Free daily buffet breakfast
Holiday Inn Express and Suites Fisherman's Wharf by IHG
Holiday Inn Express and Suites Fisherman's Wharf by IHG
3.0 star property
9.0 out of 10, Wonderful, (2200)
"Perfect stay"
United States
Lisa
The price is NT$4,270
NT$5,947 total
includes taxes & fees
Nov 2 - Nov 3
Holiday Inn Express and Suites Fisherman's Wharf by IHG
Lobby
Hotel North Beach
Hotel North Beach
2.0 star property
7.0 out of 10, Good, (1007)
"Decent rooms at a decent price"
United States
Louis
Hotel North Beach
Premium bedding, down comforters, in-room safe, desk
Harbor View Inn
Harbor View Inn
2.0 star property
9.0 out of 10, Wonderful, (594)
"This is a good well kept motel. The rooms are a good value. I would stay here again. "
United States
John
The price is NT$3,629
NT$4,270 total
includes taxes & fees
Nov 2 - Nov 3
Harbor View Inn
Exterior
Half Moon Bay Lodge
Half Moon Bay Lodge
3.0 star property
9.0 out of 10, Wonderful, (1036)
"Great hotel"
United States
Yelena
The price is NT$4,291
NT$5,036 total
includes taxes & fees
Nov 11 - Nov 12
Half Moon Bay Lodge
Terrace/patio
Hyatt Centric Fisherman's Wharf San Francisco
Hyatt Centric Fisherman's Wharf San Francisco
4.0 star property
8.6 out of 10, Excellent, (1459)
"very nice hotel and staff."
United States
Margarita
The price is NT$3,625
NT$5,532 total
includes taxes & fees
Nov 23 - Nov 24
Hyatt Centric Fisherman's Wharf San Francisco
Lobby sitting area
Hotel Riu Plaza Fisherman's Wharf
Hotel Riu Plaza Fisherman's Wharf
4.0 star property
9.0 out of 10, Wonderful, (7018)
"Wonderful stay"
United States
Ernestina
The price is NT$3,455
NT$5,332 total
includes taxes & fees
Nov 2 - Nov 3
Hotel Riu Plaza Fisherman's Wharf
Exterior
Hotel Caza Fisherman's Wharf
Hotel Caza Fisherman's Wharf
4.0 star property
9.0 out of 10, Wonderful, (3818)
"Great place to stay"
United States
Joseph
The price is NT$4,119
NT$6,258 total
includes taxes & fees
Nov 2 - Nov 3
Hotel Caza Fisherman's Wharf
Front of property
FOUND Hotel Carlton, Nob Hill
FOUND Hotel Carlton, Nob Hill
2.0 star property
8.6 out of 10, Excellent, (982)
"Very nice condition of hotel for the price. Updated interior and very friendly staff."
United States
Emma
The price is NT$2,206
NT$2,597 total
includes taxes & fees
Nov 23 - Nov 24
FOUND Hotel Carlton, Nob Hill
Exterior
Hyatt Regency San Francisco Airport
Hyatt Regency San Francisco Airport
4.0 star property
8.8 out of 10, Excellent, (1330)
"The staff is so friendly and courteous and the property is well maintained nice rooms comfortable clean anytime I head to San Francisco that is where me and my family stay"
United States
Lloyd
The price is NT$4,152
NT$5,611 total
includes taxes & fees
Nov 2 - Nov 3
Hyatt Regency San Francisco Airport
Front of property
The Lodge at Tiburon
The Lodge at Tiburon
3.5 star property
8.8 out of 10, Excellent, (1024)
"We enjoyed our stay "
United States
Xiaoyu
The price is NT$6,387
NT$8,028 total
includes taxes & fees
Nov 3 - Nov 4
The Lodge at Tiburon
Outdoor pool
The Marina Inn on San Francisco Bay
The Marina Inn on San Francisco Bay
2.5 star property
8.6 out of 10, Excellent, (2194)
"Great place to stay!"
United States
Dixon
The Marina Inn on San Francisco Bay
Exterior
SFO El Rancho Inn SureStay Collection by Best Western
SFO El Rancho Inn SureStay Collection by Best Western
3.0 star property
8.4 out of 10, Very Good, (2924)
"Always a great stay when i'm here. "
United States
Afele
The price is NT$3,492
NT$4,040 total
includes taxes & fees
Nov 3 - Nov 4
SFO El Rancho Inn SureStay Collection by Best Western
Iron/ironing board, free WiFi, bed sheets, alarm clocks
Hotel Focus SFO
Hotel Focus SFO
3.0 star property
7.6 out of 10, Good, (1476)
"Great location"
United States
Walter
The price is NT$2,463
NT$2,908 total
includes taxes & fees
Nov 23 - Nov 24
Hotel Focus SFO
Front of property - evening/night
The Pickwick Hotel
The Pickwick Hotel
3.5 star property
7.8 out of 10, Good, (1014)
"Nice stay"
United States
Orlando
The price is NT$3,081
NT$3,620 total
includes taxes & fees
Oct 30 - Oct 31
The Pickwick Hotel
Front of property - evening/night
Hotel Nikko San Francisco
Hotel Nikko San Francisco
4.5 star property
9.4 out of 10, Exceptional, (2584)
"The staff, cleanliness and amenities of this hotel were excellent "
United States
Brian
The price is NT$4,767
NT$7,023 total
includes taxes & fees
Oct 31 - Nov 1
Hotel Nikko San Francisco
Game room
Hotel Zephyr San Francisco
Hotel Zephyr San Francisco
4.0 star property
8.6 out of 10, Excellent, (2275)
"Great location- Lots of fun on site Bonus was the smore kits"
United States
STEVEN
The price is NT$3,634
NT$5,362 total
includes taxes & fees
Oct 30 - Oct 31
Hotel Zephyr San Francisco
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Where to stay in Downtown South San Francisco

Find the best Downtown South San Francisco areas and neighborhoods for the activities you enjoy most.
Union Square which includes a high rise building and a city

Union Square

Major tourist destination in downtown San Francisco, Union Square boasts shopping, hotels, and theaters. Explore department stores, boutiques, and galleries, or catch a performance at various theaters. Enjoy the Dewey Monument and stunning views from nearby hotels. Easily accessible via cable car lines, buses, and subway systems.

Fisherman\'s Wharf featuring a bay or harbor

Fisherman's Wharf

Discover Pier 39, Ghirardelli Square, and the San Francisco Maritime National Historical Park in this bustling tourist hotspot. Savor seafood at family-owned restaurants and explore the sea lion colony, while enjoying convenient cable car access.

Downtown San Francisco featuring railway items

Downtown San Francisco

Serving as San Francisco's central business district, this area boasts Northern California's two tallest buildings, the Salesforce Tower and Transamerica Pyramid. Explore shopping malls like the Embarcadero Center and enjoy parks such as Sue Biermann Park, all easily accessible via Muni bus and rail lines.

South of Market featuring skyline, a city and city views

South of Market

From baseball games to top-notch art exhibits, find endless entertainment in one of San Francisco’s fastest-growing neighborhoods.

Nob Hill showing a city and street scenes

Nob Hill

Luxury hotels, historic mansions, and Michelin-starred restaurants abound in this upscale area. Explore Union Square shopping district, Grace Cathedral, and the SF Masonic Auditorium for a taste of culture and history.

Top Downtown South San Francisco Hotel Reviews

Explore a world of travel with Expedia

Frequently asked questions

What's it like in Downtown South San Francisco?
You'll be sure to have fun visiting South San Francisco's Downtown South San Francisco neighborhood.
What's a favorite place to stay in Downtown South San Francisco?
Based on Expedia customer reviews, La Quinta Inn & Suites by Wyndham San Francisco Airport N is a highly ranked property in Downtown South San Francisco. This hotel offers free breakfast and an outdoor pool. Other favorite options in the area include Airport Inn and Inn By The SFO.
How many hotels will I find in the Downtown South San Francisco area?
When you want to kick up your feet after a day of exploring the sights in South San Francisco, you can choose from 13 Expedia hotels and other accommodations in Downtown South San Francisco.
If I need to cancel my hotel reservation in Downtown South San Francisco, will I receive a refund?
Yes, the majority of room reservations are refundable provided that you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of the scheduled arrival. If you have a reservation that's non-refundable, it might still be possible to cancel it and be given a refund within a 24-hour period of your booking. Enter dates in and click on "Search", then you can use the "fully refundable" filter to get the best deals available in Downtown South San Francisco.
Where can I learn more about changing or cancelling my trip to Downtown South San Francisco?
To find more details about picking new dates or cancelling your trip to Downtown South San Francisco, head over to our customer service page.
What can I see and do in this South San Francisco neighborhood?
See's Candies, Cinemark Century at Tanforan, and K1 Speed are just a few of the places to visit in and around Downtown South San Francisco. K1 Speed San Francisco and The Shops at Tanforan are also worth a visit when you're out sightseeing in South San Francisco.