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Southeast Missouri 4 Stars Hotels

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Our top choices for Southeast Missouri 4-star hotels

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1,009 reviews)
"Very clean, helpful staff"
United States
Cathy
The price is NT$3,231
NT$3,645 total
includes taxes & fees
Jun 17 - Jun 18
Drury Plaza Hotel Cape Girardeau Conference Center

Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO
2.5 star property
Farmington
8.0 out of 10, Very Good, (1,010 reviews)
"Very clean rooms nice staff professional and friendly delicious breakfast they have like a real restaurant buffet thanks"
United States
Jose Mario
The price is NT$1,977
NT$2,152 total
includes taxes & fees
Jun 18 - Jun 19
Baymont Inn and Suites by Wyndham Farmington, MO

The Riverview

The Riverview
4.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (595 reviews)
"Always a great place to stay in downtown Cape. Easy access to the local hangouts like Speck Pizza on Broadway."
United States
John
The price is NT$4,191
NT$4,728 total
includes taxes & fees
Jun 14 - Jun 15
The Riverview

Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG
2.5 star property
Cape Girardeau
8.0 out of 10, Very Good, (960 reviews)
"Very helpful and friendly staff. Nice room!"
United States
Michelle
The price is NT$2,784
NT$3,315 total
includes taxes & fees
Jul 1 - Jul 2
Candlewood Suites Cape Girardeau by IHG

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.6 out of 10, Exceptional, (1,010 reviews)
"Breakfast was good,pool hot tub excellent "
United States
Janica
The price is NT$3,801
NT$4,370 total
includes taxes & fees
Jun 18 - Jun 19
Drury Inn & Suites Sikeston, MO

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3.0 star property
Jackson
9.0 out of 10, Wonderful, (779 reviews)
"Beautiful hotel at a very good price."
United States
Sheldon
The price is NT$2,935
NT$3,176 total
includes taxes & fees
Jun 30 - Jul 1
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
3.0 star property
Jackson
9.6 out of 10, Exceptional, (1,016 reviews)
"The breakfast and nightly gathering makes this location a fantastic value and will be our choice of stops when heading south again!"
United States
William
The price is NT$2,946
NT$3,114 total
includes taxes & fees
Jun 29 - Jun 30
Drury Inn & Suites Jackson MO

The Farmstead Hotel

The Farmstead Hotel
2.5 star property
Caruthersville
8.6 out of 10, Excellent, (559 reviews)
"felt safe stayed only in hotel was clean and quiet and felt safe."
United States
Michael
The price is NT$2,558
NT$2,909 total
includes taxes & fees
Jun 18 - Jun 19
The Farmstead Hotel

Drury Inn & Suites Hayti Caruthersville

Drury Inn & Suites Hayti Caruthersville
3.0 star property
Hayti
9.4 out of 10, Exceptional, (1,009 reviews)
"Great place"
United States
Sonya
The price is NT$3,104
NT$3,538 total
includes taxes & fees
Jun 28 - Jun 29
Drury Inn & Suites Hayti Caruthersville

Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1,010 reviews)
"Great hotel"
United States
mason
The price is NT$2,436
NT$2,748 total
includes taxes & fees
Jun 23 - Jun 24
Pear Tree Inn Cape Girardeau West

Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (196 reviews)
"The hotel was super clean, very friendly, the beds were very comfortable."
United States
Candia
The price is NT$2,931
NT$3,307 total
includes taxes & fees
Jul 5 - Jul 6
Fairfield Inn & Suites by Marriott Cape Girardeau

La Quinta Inn & Suites by Wyndham Festus - St. Louis South

La Quinta Inn & Suites by Wyndham Festus - St. Louis South
3.0 star property
Festus
8.0 out of 10, Very Good, (1,001 reviews)
"Clean room, check in was easy. It was a good stopover for 1 night."
United States
Nancy
The price is NT$2,666
NT$3,048 total
includes taxes & fees
Jun 25 - Jun 26
La Quinta Inn & Suites by Wyndham Festus - St. Louis South

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1,001 reviews)
"The room was very spacious and great water pressure. Staff very kind to us, the breakfast was great as well"
United States
Theresa
The price is NT$3,611
NT$4,074 total
includes taxes & fees
Jun 21 - Jun 22
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Honeysuckle Inn - Mountain View

Honeysuckle Inn - Mountain View
3.0 star property
Mountain View
8.6 out of 10, Excellent, (361 reviews)
"Simple no frills hotel that we've stayed at a few times while traveling."
United States
Monica
The price is NT$3,136
NT$3,400 total
includes taxes & fees
Jun 14 - Jun 15
Honeysuckle Inn - Mountain View

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau
3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1,012 reviews)
"I will definitely be staying here next time I visit SEMO."
United States
Lee
The price is NT$2,851
NT$3,216 total
includes taxes & fees
Jun 28 - Jun 29
Drury Inn & Suites Cape Girardeau

Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO
2.0 star property
Poplar Bluff
8.0 out of 10, Very Good, (1,000 reviews)
"Clean and parking was easy."
United States
Amy
The price is NT$2,373
NT$2,657 total
includes taxes & fees
Jun 19 - Jun 20
Motel 6 Poplar Bluff, MO

Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston
2.0 star property
Sikeston
7.2 out of 10, Good, (1,007 reviews)
"When I stay at hotels I like to find hotels like this one for the $$$ value . This hotel was clean and the bed was very comfortable. Room 237 . I didn’t hear any interstate noise . I didn’t eat the breakfast but the coffee was very good . I would stay here again ."
United States
Kurt
The price is NT$2,316
NT$2,640 total
includes taxes & fees
Jun 30 - Jul 1
Days Inn and Suites by Wyndham Sikeston

Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North
2.5 star property
Cape Girardeau
7.2 out of 10, Good, (754 reviews)
"We would stay here again"
United States
Pamela
The price is NT$2,136
NT$2,409 total
includes taxes & fees
Jun 24 - Jun 25
Quality Inn Cape Girardeau North

Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (870 reviews)
"Nice quiet overnight stay."
United States
Tammy
The price is NT$3,100
NT$3,471 total
includes taxes & fees
Jul 6 - Jul 7
Hampton Inn Poplar Bluff

Baymont by Wyndham Festus

Baymont by Wyndham Festus
3.0 star property
Festus
6.8 out of 10, (971 reviews)
"It looks as if the property is undergoing a renovation. But it was still worthy of the stay. The renovation was not disruptive, or unsightly. Lots of parking close to a lot of different restaurants. Not far off the interstate as well. Would definitely book there again. "
Canada
Philip
The price is NT$2,217
NT$2,536 total
includes taxes & fees
Jun 21 - Jun 22
Baymont by Wyndham Festus
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Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from K Bridge Recreation Area to Clearwater Lake.

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Top Southeast Missouri Hotel Reviews

Frequently asked questions

How much does it cost to stay in a 4-star hotel in Southeast Missouri?
To book a 4-star hotel in Southeast Missouri that matches your budget, take advantage of Expedia's handy search filters. Browse the available options during your chosen dates and use our pricing filter to set your limit. You can also list your results by the cheapest stay first.

  • Search for the lowest price from NT$4,728

What's the difference between 5-star and 4-star hotels in Southeast Missouri?
Treat yourself to refined living during your Southeast Missouri vacation by choosing a 4-star hotel. As well as featuring upmarket surroundings, these retreats are typically packed with amenities, including complimentary bathrobes, large beds and more. A 5-star hotel will go above and beyond to make your trip an even more lavish and memorable one. 24-hour front desk, on-site spas and gourmet dining are a few of the superior services and conveniences you'll likely have access to.
Does Southeast Missouri have any 4-star all-inclusive resorts?
Enjoy a stress-free vacation experience where everything is included in the upfront price by using our "All inclusive" filter. Budgeting is easy when your room, meals and many activities are already taken care of. Eager for more ideas? Check out the amazing deals on Expedia's standard 4-star hotels in and around Southeast Missouri too.

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