Top Spa Florida Keys Hotels

Cheeca Lodge & Spa

81801 Overseas Highway, Mile Marker 82, Marker 82, Islamorada, FL

3 hours drive from Duval Street

Stay at this 5-star luxury resort in Islamorada. Enjoy free parking, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff ...

9/10 Wonderful! (1,157 reviews)

Travelers like: full-service spa, sauna, steam room, massage

Travelers say...

"Excellent place for a restful weekend"

Reviewed on 2025/8/23

Pier House Resort & Spa

1 Duval St, Key West, FL

11 min walk from Duval Street

Stay at this 4-star beach resort in Key West. Enjoy a full-service spa, a private beach, and 2 bars/lounges. Our guests praise the pool and the bar in our reviews. ...

9/10 Wonderful! (1,005 reviews)

Travelers like: full-service spa, massage, facials, manicures and pedicures

Travelers say...

"It was fabulous. The staff was amazing and we enjoyed the pool, beach and restaurant. My only suggestion is they add a pet walking area with turf. There is no grass on the property for pet relief."

Reviewed on 2025/8/24

Southernmost Beach Resort and Guesthouses

1319 Duval Street, Key West, FL

11 min walk from Duval Street

Stay at this 4-star beach hotel in Key West. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the bar in our reviews. ...

8.6/10 Excellent! (2,701 reviews)

Travelers like: full-service spa, massage, facials, couples spa treatments

Travelers say...

"Out dated."

Reviewed on 2025/8/24

See all 8,274 properties in Florida Keys

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.