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Top Spa Florida Keys Hotels

Cheeca Lodge & Spa

81801 Overseas Highway, Mile Marker 82 Islamorada FL

3 hours drive from Florida Keys Beaches

Book a stay at this luxury resort in Islamorada. Enjoy free parking, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff ...

9.2/10 Wonderful! (1,329 reviews)

Travelers like: full-service spa, sauna, steam room, massage

Travelers say...

"The decor was updated a bit but then dated in other areas. The balcony cushions had stains and the carpet needed to be replaced."

Reviewed on 2026/6/23

Pier House Resort & Spa

1 Duval St Key West FL

37 min drive from Florida Keys Beaches

Book a stay at this beach resort in Key West. Enjoy a full-service spa, a private beach, and 2 bars/lounges. Our guests praise the pool and the helpful staff ...

9/10 Wonderful! (1,187 reviews)

Travelers like: full-service spa, massage, facials, manicures and pedicures

Travelers say...

"Not all the rooms that say have a roll in shower actually do. The swimming pool wheelchair lift does not work. The rooms that have roll in showers are nice but not Junior Suites."

Reviewed on 2026/6/24

Southernmost Beach Resort and Guesthouses

1319 Duval Street Key West FL

36 min drive from Florida Keys Beaches

Book a stay at this beach hotel in Key West. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...

8.8/10 Excellent! (3,402 reviews)

Travelers like: full-service spa, massage, facials, couples spa treatments

Travelers say...

"The room was very clean. The staff was helpful."

Reviewed on 2026/6/24

See all 8,301 properties in Florida Keys

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.