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Top Luxury Eastern Piedmont Hotels

The Umstead Hotel and Spa

100 Woodland Pond Dr Cary NC

29 min drive from Duke University

Pamper yourself with an extravagant stay at The Umstead Hotel and Spa, where you'll find deep soaking bathtubs and pillowtop beds. The spa, outdoor pool, and ...

9.6/10 Exceptional! (760 reviews)

Very nice facilities. Great staff.

Reviewed on 2026/5/1

The Carolina Inn, a Destination by Hyatt Hotel

211 Pittsboro Street Chapel Hill NC

16 min drive from Duke University

Go for a luxurious stay at The Carolina Inn, a Destination by Hyatt Hotel, where you can enjoy amenities like pillowtop beds, premium channels, and more. Notable ...

9.6/10 Exceptional! (1,001 reviews)

The Hotel and the staff were lovely, unfortunately we did not have a car, so we needed cabs for shops and restaurants.

Reviewed on 2026/4/27

The Mayton

301 S Academy St Cary NC

37 min drive from Duke University

The Mayton is one of the Cary luxury 4-star boutique properties where you can pamper yourself with Champagne service, pillowtop beds, and more. Notable amenities ...

9.4/10 Exceptional! (749 reviews)

State’s breakfast credit on site. There was no breakfast credit or discount,

Reviewed on 2026/4/27

See all 4,956 properties in Eastern Piedmont

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.