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Top Luxury Southwest Coast Florida Hotels

Wyvern Hotel, an Ascend Collection Hotel

101 E Retta Esplanade Punta Gorda FL

1 hour drive from Siesta Key Beach

Stay in the lap of luxury at Wyvern Hotel, an Ascend Collection Hotel, where you can enjoy amenities like plush bedding, designer toiletries, and more. Deluxe ...

9/10 Wonderful! (1,007 reviews)

"The front desk staff was super friendly. The bartender in the lobby par was the best. food was great at the roof top bar. we took delivery on a boat we purchased and the dock area made it so convenient. will stay again"

Reviewed on 2026/5/24

Naples Grande Beach Resort

475 Seagate Drive Naples FL

3 hours drive from Siesta Key Beach

Naples Grande Beach Resort is one of the Naples lavish 4.5-star beach properties where you can treat yourself to deep soaking bathtubs and massage services. ...

The Ritz-Carlton, Sarasota

1111 Ritz Carlton Dr Sarasota FL

12 min drive from Siesta Key Beach

The Ritz-Carlton, Sarasota is a Sarasota luxury 5-star beach property where you can treat yourself to pillowtop beds, designer toiletries, and more. The 2 outdoor ...

9.2/10 Wonderful! (1,004 reviews)

"Me gustó todo de la propiedad"

Reviewed on 2026/5/25

See all 46,654 properties in Southwest Coast Florida

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.