Southeast Missouri Kid friendly Vacations 2026

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Top Kid friendly Southeast Missouri Hotels

Drury Inn & Suites Sikeston, MO

2608 East Malone Ave, Miner Sikeston MO

4 hours drive from Mark Twain National Forest

Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...

9.6/10 Exceptional! (1,006 reviews)

"Great stay and friendly, nice staff! Loved it!"

Reviewed on 2026/9/15

Best Western Plus Sikeston I-55

120 S Interstate Drive Sikeston MO

4 hours drive from Mark Twain National Forest

Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...

8.4/10 Very Good! (1,004 reviews)

"Room were clean, staff was very courteous and helpful."

Reviewed on 2026/9/15

Drury Inn & Suites Cape Girardeau

3303 Campster Drive Cape Girardeau MO

5 hours drive from Mark Twain National Forest

Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...

See all 693 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.