Photo by Southernmost Illinois Tourism Bureau

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Top Adventure Southwest Illinois Hotels

SureStay Hotel by Best Western Whittington Rend Lake

13277 Freeway Lane Whittington IL

1 hour drive from Southern Illinois University

Book a stay at this business-friendly hotel in Whittington. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...

Hampton Inn Carbondale

2175 Reed Station Pkwy Carbondale IL

10 min drive from Southern Illinois University

Book a stay at this business-friendly hotel in Carbondale. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...

8.4/10 Very Good! (659 reviews)

"Very nice Hampton Inn, property was very clean, room was spacious. Staff were helpful. The pool was down due to maintenance work, but the fitness center was very nice."

Reviewed on 2026/7/21

Days Inn & Suites by Wyndham Caseyville

2423 Old Country Inn Drive Caseyville IL

3 hours drive from Southern Illinois University

Book a stay at this business-friendly hotel in Caseyville. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Pleasant Ridge Park and ...

4/10 (356 reviews)

"Everything was filthy, including the blankets and pillows on the bed. Every single towel was gross. It smelt like drugs throughout the whole place."

Reviewed on 2026/7/21

See all 770 properties in Southwest Illinois

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.