Photo by Southernmost Illinois Tourism Bureau

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Top Pet-friendly Southern Illinois Hotels

La Quinta Inn & Suites by Wyndham Effingham

1103 Avenue Of Mid America Effingham IL

4 hours drive from Shawnee National Forest

This pet-friendly hotel welcomes dogs and cats (fees apply).

9.2/10 Wonderful! (1,004 reviews)

"Everything was clean and new. We arrived late and left early, so we did not spend much time there, but it was a pleasant stay"

Reviewed on 2026/6/30

La Quinta Inn & Suites by Wyndham O'Fallon, IL - St. Louis

136 Regency Park O'Fallon IL

4 hours drive from Shawnee National Forest

This pet-friendly hotel welcomes dogs and cats (fees apply).

5.8/10 (1,001 reviews)

"It was dated it felt dirty, our drawer with the television on top had a collapsed, broken splinter side I wouldn’t ever stay there again"

Reviewed on 2026/6/25

Red Roof Inn St Louis - Troy, IL

2030 Formosa Road Troy IL

4 hours drive from Shawnee National Forest

Make it a pet-friendly trip and bring along your four-legged friend. Dogs and cats are welcome (fees apply) at this city-center hotel.

7.8/10 Good! (1,002 reviews)

"We stay here every time we are in town. The place is always clean, and the staff is very helpful and kind."

Reviewed on 2026/6/29

See all 1,143 properties in Southern Illinois

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.