Southern Illinois Pet-friendly Vacations
Book a Pet-friendly Hotel + Flight or Car together to unlock savings
Photo by Southernmost Illinois Tourism Bureau
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Save up to NT$5,067 when you book a flight and hotel together*
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Top Pet-friendly Southern Illinois Hotels
La Quinta Inn & Suites by Wyndham Effingham
1103 Avenue Of Mid America, Effingham, IL
This pet-friendly hotel welcomes dogs and cats (fees apply).
9/10 Wonderful! (1,008 reviews)
"Room was clean . The staff was friendly and helpful. Overall appearance of the property was great"
Reviewed on 2025/8/11
La Quinta Inn & Suites by Wyndham O'Fallon, IL - St. Louis
136 Regency Park, O'Fallon, IL
This pet-friendly hotel welcomes dogs and cats (fees apply).
6/10 (1,003 reviews)
One Night Stay
"We are traveling across country on a budget so for the price this was an excellent stay. Comfortable bed, real shower. Here are some issues, if mitigated, would have uped my review to 4. Hallway carpet and room carpet need a good cleaning. Overhead light in room was burned out,, refrigerator cabinet ..."
Reviewed on 2025/7/31
Red Roof Inn St Louis - Troy, IL
2030 Formosa Road, Troy, IL
Make it a pet-friendly trip and bring along your four-legged friend. Dogs and cats are welcome (fees apply) at this city-center hotel.
7.6/10 Good! (1,002 reviews)
"Commode eats was loose."
Reviewed on 2025/8/7
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.