Southern Illinois Pet-friendly Vacations
Book a Pet-friendly Hotel + Flight or Car together to unlock savings
Photo by Southernmost Illinois Tourism Bureau
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Top Pet-friendly Southern Illinois Hotels
La Quinta Inn & Suites by Wyndham Effingham
1103 Avenue Of Mid America, Effingham, IL
This pet-friendly hotel welcomes dogs and cats (fees apply).
9/10 Wonderful! (1,009 reviews)
"I had a stressful day and arrived in the middle of the night. The staff was super kind and helpful!"
Reviewed on 2025/7/11
La Quinta Inn & Suites by Wyndham O'Fallon, IL - St. Louis
136 Regency Park, O'Fallon, IL
This pet-friendly hotel welcomes dogs and cats (fees apply).
6.2/10 (1,003 reviews)
Honest review
"Room was clean and everything else. However the smell when you go through those doors are not the best, stink really bad."
Reviewed on 2025/6/30
Red Roof Inn St Louis - Troy, IL
2030 Formosa Road, Troy, IL
Make it a pet-friendly trip and bring along your four-legged friend. Dogs and cats are welcome (fees apply) at this city-center hotel.
7.6/10 Good! (1,004 reviews)
"I wish they had a hot breakfast, with waffles. Other than that it was a great stay!!"
Reviewed on 2025/7/4
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.