Plan, book, travel with confidence
Better together
Save up to NT$25,000 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place

Top Luxury Southeast Jacksonville Hotels

Tricove Inn & Suites

4300 Salisbury Rd Jacksonville FL

11 min drive from Mayo Clinic Florida

Pamper yourself with a luxe vacation at Tricove Inn & Suites. Notable amenities at this motel include an outdoor pool and a fitness center.

7.2/10 Good! (1,003 reviews)

"Nice. Place"

Reviewed on 2026/6/6

Red Roof Inn PLUS+ Jacksonville - Southpoint

6969 Lenoir Avenue E Jacksonville FL

11 min drive from Mayo Clinic Florida

Be treated to a luxury stay at Red Roof Inn PLUS+ Jacksonville - Southpoint, where you can enjoy amenities like premium channels, flat-screen TVs, and more. ...

Wyndham Garden Jacksonville

4660 Salisbury Road Jacksonville FL

10 min drive from Mayo Clinic Florida

Choose luxury at Wyndham Garden Jacksonville, where you can enjoy amenities like memory foam beds, premium channels, and more. The outdoor pool, beach bar, and ...

8/10 Very Good! (1,900 reviews)

"It's like a TEMU Wyndham .. has the name but is like a cheap knock-off that just doesn't fit right The check-in was rude. I showed up 10 min before check-in and was informed that she normally would charge me $30 for early check-in, but this time she would let it slide. Then proceeded to lecture me ..."

Reviewed on 2026/6/4

See all 589 properties in Southeast Jacksonville

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.