Photo by JG Morris

Plan, book, travel with confidence
Better together
Save up to NT$5,067 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place

Top Kid friendly Southeast Missouri Hotels

Drury Inn & Suites Sikeston, MO

2608 East Malone Ave, Miner Sikeston MO

4 hours drive from Mark Twain National Forest

Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...

9.4/10 Exceptional! (1,005 reviews)

As always it was a perfect visit

Reviewed on 2026/1/19

Pear Tree Inn Sikeston

2602 E Malone Avenue Sikeston MO

4 hours drive from Mark Twain National Forest

Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...

9.2/10 Wonderful! (1,001 reviews)

Clean room. Nice facilities. Pool is half inside half outside so even though it was heated it was still very cold

Reviewed on 2026/1/19

Best Western Plus Sikeston

120 S Interstate Drive Sikeston MO

4 hours drive from Mark Twain National Forest

Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...

8.2/10 Very Good! (1,002 reviews)

Clean and well-kept

Reviewed on 2026/1/19

See all 622 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.