Northeast Missouri Adults Only Vacations 2026

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Top Adults Only Northeast Missouri Hotels

Historic Iron Horse Inn

207 E. 4th Street Hermann MO

2 hours drive from St. Louis Union Station

Stay at this B&B in Hermann. Enjoy free breakfast, free parking, and a garden. Popular attractions Tin Mill Brewery and Hermannhof Vineyards are located ...

8.4/10 Very Good! (21 reviews)

"The inn keeper was fabulous. The rooms were clean and cozy. Will defiantly be back."

Reviewed on 2023/10/30

Moonrise Hotel

6177 Delmar Blvd St. Louis MO

10 min drive from St. Louis Union Station

Book a stay at this boutique hotel in St. Louis. Enjoy free WiFi, free parking, and 2 bars/lounges. Our guests praise the restaurant and the helpful staff in ...

9/10 Wonderful! (2,031 reviews)

"The room could use a few more usb charging ports. But very nice"

Reviewed on 2026/10/2

See all 3,002 properties in Northeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.