Photo by Andrew Hershfeld

Plan, book, travel with confidence
Better together
Save up to NT$5,067 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place

Top Adults Only Northeast Missouri Hotels

Historic Iron Horse Inn

207 E. 4th Street Hermann MO

2 hours drive from St. Louis Union Station

Stay at this B&B in Hermann. Enjoy free breakfast, free parking, and a garden. Popular attractions Deutschheim State Historic Site and Hermannhof Vineyards are ...

The inn keeper was fabulous. The rooms were clean and cozy. Will defiantly be back.

Reviewed on 2023/10/30

Moonrise Hotel

6177 Delmar Blvd St. Louis MO

10 min drive from St. Louis Union Station

Book a stay at this boutique hotel in St. Louis. Enjoy free WiFi, free parking, and 2 bars/lounges. Our guests praise the restaurant and the helpful staff in ...

9/10 Wonderful! (1,915 reviews)

It was a great experience

Reviewed on 2025/12/16

See all 2,791 properties in Northeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.