Motel 6 Hotels in Upstate South Carolina
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An aerial view of a park with a winding path, trees in autumn colors, and a bridge.

Motel 6 Upstate South Carolina hotels

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Our top choices for Upstate South Carolina Motel 6

A modern bedroom with a large bed, a built-in TV, and a small desk.

A reception area with a modern design, including a large number '6' sign, a coffee machine, and a TV mounted on the wall.

A laundry room with three stacked washing machines, a power outlet, and a water heater.

A motel with multiple floors, balconies, and a parking lot.

1. Motel 6 Spartanburg, Sc – Northwest / Business 85

Motel 6 Spartanburg, Sc – Northwest / Business 85

2.0 star property

Spartanburg

7.6 out of 10, Good, (204 reviews)

7.6/10

Good

(204 reviews)

"The rooms are very clean staff is very helpful very quiet area recommend anyone to stay here"

Connie

The price is NT$1,899

NT$1,899

NT$2,108 total

includes taxes & fees

Nov 22 - Nov 23

Motel 6 Spartanburg, Sc – Northwest / Business 85

A reception area with a counter, seating, and a television.

A kitchen with dark wooden cabinets, a stainless steel microwave, a built-in oven, a sink with a faucet, and a black countertop.

A hotel room with a bed, a desk, a chair, a TV, and a kitchenette.

Three Pepsi vending machines in a hallway with a wooden floor and white walls.

2. Motel 6 Greenville, SC

Motel 6 Greenville, SC

2.0 star property

Greenville

5.6 out of 10, (944 reviews)

5.6/10

(944 reviews)

"The rooms were clean, and the staff was very attentive—good service."

Cesar

The price is NT$1,642

NT$1,642

NT$1,806 total

includes taxes & fees

Nov 26 - Nov 27

Motel 6 Greenville, SC

A compact kitchen with a black refrigerator, a microwave, and a double sink.

A motel with a large parking lot, a sign indicating room number 6, and a well-lit entrance.

A reception area with a dark counter, two digital screens displaying 'Studio 6 Extended Stay', a coffee station, and a door in the background.

A hotel room with a bed, two bedside tables, a nightstand, and a wall-mounted lamp.

3. Motel 6 Greenville, SC - I-85 Near Downtown

Motel 6 Greenville, SC - I-85 Near Downtown

2.0 star property

Greenville

7.0 out of 10, Good, (462 reviews)

7.0/10

Good

(462 reviews)

"Only thing I liked was the price. I stayed 1 night and merely needed a place to sleep."

Todd

The price is NT$1,906

NT$1,906

NT$2,097 total

includes taxes & fees

Dec 6 - Dec 7

Motel 6 Greenville, SC - I-85 Near Downtown

A hotel room with two beds, a desk with a computer, a TV, and a window with curtains.

A modern hotel with a curved building, a stone bridge, and a river.

A golf course with multiple greens and a large building in the background.

A lobby with a check-in counter, seating area, and a computer station.

4. Motel 6 Simpsonville, SC - Greenville

Motel 6 Simpsonville, SC - Greenville

2.0 star property

Simpsonville

7.4 out of 10, Good, (388 reviews)

7.4/10

Good

(388 reviews)

"Clean room and staff are so good"

MIGUEL

The price is NT$2,464

NT$2,464

NT$2,711 total

includes taxes & fees

Nov 14 - Nov 15

Motel 6 Simpsonville, SC - Greenville

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

View all properties

Top Upstate South Carolina Hotel Reviews

A restaurant with a bar area, green upholstered seating, and a view of trees through large windows.

A bar with multiple shelves of liquor bottles and glasses hanging above.

A modern living room with a fireplace, seating area, and a bar with shelves of bottles.

A large, two-story house with a symmetrical facade, large windows, and a central entrance.

Hotel Hartness

Greenville

10/10 Excellent

The hotel is top notch. The rooms were thoughtfully decorated and there were many amenities. Breakfast was wonderful.

Gracie

Reviewed April 22, 2025Reviewed April 22, 2025

Hotel Hartness

A spacious hallway with a wooden ceiling, a sofa, a chair, and a lamp.

A hotel lobby with a long corridor, seating areas, and a reception desk.

A modern restaurant with a marble-top dining table, blue upholstered chairs, and a variety of food items displayed in the background.

The Inn at Patrick Square

Clemson

10/10 Excellent

This was an absolutely beautiful and VERY clean hotel. It is not too far from Clemson University. We will stay here for all of our visits to Clemson.

SHARRA

Reviewed August 23, 2022Reviewed August 23, 2022

The Inn at Patrick Square

A multi-level interior with a spiral staircase, wooden railings, and a seating area with tables and chairs.

A spacious restaurant with high ceilings, wooden flooring, and a mix of modern and classic furniture.

A spacious living area with a sofa, ottoman, and chairs, a dining area with a table, and a kitchen in the background.

An outdoor patio with wicker furniture, a round table, and a fountain.

The Shepherd Hotel Downtown Clemson

Clemson

10/10 Excellent

We had an amazing stay. From the beautifully decorated, relaxing room, to the restaurant decor and excellent service and food, to the cute coffee stations on each floor, to the bar and deck, it was all fantastic!

Amy

Reviewed July 14, 2025Reviewed July 14, 2025

The Shepherd Hotel Downtown Clemson

A hotel entrance with a stone facade, a wooden door, and potted plants.

A two-story building with a brick facade, a central entrance with a curved arch, and a balcony on the second floor.

A living room with a fireplace, a television mounted above it, and two sofas with floral cushions.

A restaurant with wooden ceiling beams, stone walls, and red patterned curtains. Tables are set with white tablecloths and candles.

The Bleckley Inn

Anderson

10/10 Excellent

Very nice property. Conveniently located in downtown.

Anonymous traveler

Reviewed February 19, 2020Reviewed February 19, 2020

The Bleckley Inn

A covered outdoor area with a grill and seating, surrounded by brick walls and windows.

A modern hotel lobby with a seating area featuring a sofa and round tables, large windows, and contemporary lighting fixtures.

An indoor swimming pool with clear water, surrounded by a brick building with multiple windows and outdoor seating areas.

A multi-story building with a prominent corner entrance, large windows, and a street intersection with traffic lights.

Homewood Suites by Hilton Greenville Downtown

Greenville Downtown

10/10 Excellent

Very spacious rooms, super clean

Michele

Reviewed June 22, 2025Reviewed June 22, 2025

Homewood Suites by Hilton Greenville Downtown

An outdoor patio with a modern design, featuring a seating area with sofas and a fire pit, surrounded by plants and under a pergola with hanging lights.

A modern interior with a bar area, seating, and a staircase.

A modern hotel lobby with a central seating area, a long reception desk, and a kitchen area visible to the right.

A bar area with a central island, multiple bar stools, hanging spherical light fixtures, and a stone pillar.

SpringHill Suites by Marriott Greenville Downtown

Greenville Downtown

10/10 Excellent

Beautiful hotel and convenient for walking anywhere downtown. The breakfast was delicious with hot and cold options that varied a little each day. Loved the flavored water machine. Best free breakfast I’ve ever had at a hotel. The gym was also very nice.

Sherri

Reviewed February 18, 2023Reviewed February 18, 2023

SpringHill Suites by Marriott Greenville Downtown

An indoor swimming pool with a tiled floor, a covered area, and a seating area with chairs.

A hotel room with two beds, a wooden headboard, a nightstand with a lamp, and a red accent wall.

A modern hotel lobby with a wooden cabinet, a flat-screen TV, a sofa, and a table.

A modern restaurant with high ceilings, large windows, and a mix of seating options including booths and tables.

Drury Inn & Suites Greenville

Greenville

10/10 Excellent

Very nice hotel. Would stay again.

hope

Reviewed April 26, 2024Reviewed April 26, 2024

Drury Inn & Suites Greenville

A modern lounge area with a brick accent wall, a fireplace, and comfortable seating.

A modern living room with a sofa, two armchairs, a coffee table, and a potted plant.

A multi-story hotel with a prominent entrance, a parking lot, and a landscaped area with a small tree.

A bar area with a counter, multiple chairs, and a display of bottles and glasses.

The Abernathy of Clemson

Clemson

10/10 Excellent

Amazing hotel, amazing location. Highly recommended.

Michele

Reviewed April 3, 2026Reviewed April 3, 2026

The Abernathy of Clemson

A hotel entrance with a stone facade, a bench, and a trash bin.

A Holiday Inn Express & Suites hotel with a modern design, featuring a brick facade and multiple windows.

A hotel lobby with a reception desk, seating areas, and a corridor leading to other rooms.

An outdoor patio area with tables and chairs, a building with large windows, and a clear sky.

Holiday Inn Express & Suites Greenville SE - Simpsonville by IHG

Simpsonville

10/10 Excellent

Wonderful friendly staff. Rooms were very clean and well maintained.

Amy

Reviewed November 8, 2026Reviewed November 8, 2026

Holiday Inn Express & Suites Greenville SE - Simpsonville by IHG

A multi-story hotel with a stone facade, large windows, and outdoor seating areas.

A modern building with a covered outdoor seating area and a sign reading "The Commons".

A hotel room with a patterned sofa, a round ottoman, a desk with a chair, a large mirror, and a television.

A spacious dining area with round tables and chairs, large windows with sheer curtains, and pendant lighting.

Hampton Inn & Suites Greenville-Downtown-RiverPlace

Greenville Downtown

10/10 Excellent

Bathroom was great, love the anti fog back lit mirror. bedding & pillows just ok. ( fitted sheet, didnt fit well, pillows too soft). No onsite parking. We paid for valet service. Otherwise, you pay at city owned lots.

Colleen

Reviewed January 5, 2025Reviewed January 5, 2025

Hampton Inn & Suites Greenville-Downtown-RiverPlace

A modern lobby with a reception desk, seating area, and a kitchen in the background.

A Courtyard Marriott hotel with a modern design, featuring a prominent entrance with glass doors and a covered walkway.

A hotel exterior with large windows, outdoor seating, and potted plants.

A spacious dining area with multiple tables and chairs, large windows, and hanging pendant lights.

Courtyard by Marriott Greenville Downtown

Greenville Downtown

10/10 Excellent

Great facilities, fantastic location for downtown Greenville.

Billy

Reviewed July 6, 2021Reviewed July 6, 2021

Courtyard by Marriott Greenville Downtown

A modern restaurant interior with round tables and chairs, a kitchen area, and large windows offering a view of parked cars outside.

A modern kitchen with a central island, three bar stools, pendant lighting, and a decorative flower arrangement.

A pool area with lounge chairs and a sign for Best Western Plus.

A hotel room with a large bed, a desk with a chair, a blue armchair, a wooden nightstand with a lamp, and a wardrobe with a mirror.

Best Western Plus Greenville I-385 Inn & Suites

Greenville

10/10 Excellent

The staff was welcoming and very helpful. The room was nice. The breakfast was great!

Kara

Reviewed July 21, 2025Reviewed July 21, 2025

Best Western Plus Greenville I-385 Inn & Suites

A bar area with a long counter, multiple stools, and shelves stocked with bottles.

A spacious lobby with a bar area, seating, and large windows.

A restaurant with a central island seating area, multiple tables, and a large mural on the wall.

A hotel entrance with a covered walkway, a landscaped area with trees, and a well-lit building facade.

Hilton Garden Inn Spartanburg

Spartanburg

10/10 Excellent

Clean, quite, and well furnished. Staff when out of their way to meet our request.

Anonymous traveler

Reviewed May 14, 2019Reviewed May 14, 2019

Hilton Garden Inn Spartanburg

A rooftop bar with seating, a bar area, and a view of the cityscape at dusk.

A modern restaurant with a bar area, high ceilings, and a view of the cityscape.

A spacious living area with a modern sofa, armchairs, a coffee table, and a dining area with chairs and a table.

A modern living room with a dark-colored sofa, armchairs, a coffee table, and a bookshelf filled with decorative items.

AC Hotel by Marriott Spartanburg

Spartanburg

10/10 Excellent

Great hotel with restaurants within walking distance. Great pool for kids, lots of room. Staff was extremely pleasant and professional.

Josiah

Reviewed August 22, 2022Reviewed August 22, 2022

AC Hotel by Marriott Spartanburg

A golf course with a water body, trees, and a distant view of a bridge.

A large, curved swimming pool with lounge chairs and umbrellas, surrounded by landscaped areas and a building in the background.

An outdoor patio with tables and chairs, surrounded by trees and a view of a body of water.

A golf course with a clubhouse, surrounded by dense trees and a large body of water.

Clemson University's James F. Martin Inn

Clemson

10/10 Excellent

It was very clean and quiet- well kept and a nice play to come “home” to after a long, emotional day of dropping daughter off at Clemson!!

Margot

Reviewed August 23, 2021Reviewed August 23, 2021

Clemson University's James F. Martin Inn

A modern kitchen with hanging light fixtures and bar seating.

A modern hotel building with a sign reading 'DOUBLETREE by Hilton' and a clear sky with clouds.

A swimming pool with a lifeguard stand, surrounded by stone walls and a covered patio area with chairs and umbrellas.

A hotel with a modern design, featuring a prominent 'DoubleTree by Hilton' sign.

DoubleTree by Hilton Greenville Woodruff Road

Greenville

10/10 Excellent

Love the hotel we stay there every time we visit my daughter at Clemson, it’s very clean the staff is so friendly and just so convenient

antonella

Reviewed November 9, 2026Reviewed November 9, 2026

DoubleTree by Hilton Greenville Woodruff Road

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Motel 6 Upstate South Carolina hotels

Change your mind

Treat yourself

Be picky

Check prices for these dates

Our top choices for Upstate South Carolina Motel 6

1. Motel 6 Spartanburg, Sc – Northwest / Business 85

2. Motel 6 Greenville, SC

3. Motel 6 Greenville, SC - I-85 Near Downtown

4. Motel 6 Simpsonville, SC - Greenville

Top Upstate South Carolina Hotel Reviews

Hotel Hartness

10/10 Excellent

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