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November 2026

December 2026

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Our top choices for Upstate South Carolina guest houses

A rustic cabin with a metal roof, a deck with Adirondack chairs, and a fire pit.

1. Outpost Inn

Highlands

Erin

NT$6,311 total

includes taxes & fees

Nov 10 - Nov 11

View all properties

Learn more about Upstate South Carolina

Experience the family-friendly area of Upstate South Carolina—live music, restaurants, and sights from Discovery Island Water Park to Frankie's Fun Park.

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Resorts & Hotels with Spas in Payne-Logan
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Motels in Gowensville
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Hotels near Greenville-Pickens Speedway
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Cabin Rentals in Chesnee
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Cheap Hotels in Greenville
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Hotels near Swamp Rabbit Trail
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Business Hotels in Greenville - Spartanburg
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Motels in Laurens
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Motels in Greenville - Spartanburg
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Hotels with Early Check-in in Upstate South Carolina
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Hotels near Bob Jones University
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Hotels with Hot Tubs in Piedmont
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4 Star Hotels in Greenville - Spartanburg
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Simpsonville Hotels
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Pet-Friendly Hotels in Simpsonville
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Hotels near Cedar Lane Shopping Center
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Hotels near Topgolf Greenville
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Cabin Rentals in Campobello
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Hotels near Lakeside Park
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Cabin Rentals in Upstate South Carolina
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Hotels with Bars in Greenville Downtown
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Pet-Friendly Hotels in Greenville Downtown
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Romantic Hotels in Greenville Downtown
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Vacation Homes in Pickens County
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B&B in Starr
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Greenville Hotels
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Cabin Rentals in Easley
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Resorts & Hotels with Spas in Greenville - Spartanburg
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Hotels near Bon Secours Wellness Arena
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Cheap Hotels in Greenville Downtown
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Business Hotels in Greenville Downtown
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Hotels near Runway Park at GMU
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Hotels with Free Parking in Greenville - Spartanburg
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Resorts in Cleveland
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Piedmont Hotels
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Ski Hotels in Upstate South Carolina
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B&B in Boiling Springs
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Luxury Hotels in Greenville Downtown
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Apartments in Duncan
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Motels in Lyman
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Chalets in Tigerville
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Pet-Friendly Hotels in Piedmont
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Hotels near Greenville Zoo
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Cheap Hotels in Greenville - Spartanburg
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Flights from Independence and Mango Creek (INB) to Greenville (GSP)
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Flights from Pelzer
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Flights from San Francisco (SFO) to Greenville (GSP)
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Flights from Billings (BIL) to Greenville (GSP)
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Flights from Palembang (PLM) to Greenville (GSP)
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Flights from Hazleton (HZL) to Greenville (GSP)
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Flights from Taylors
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Flights from Dhaka (DAC) to Greenville (GSP)
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Flights from Genoa (GOA) to Greenville (GSP)
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Flights from Stuttgart (SGT) to Greenville (GSP)
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Flights from Simpsonville
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Flights from Taipei (TPE) to Greenville (GDC)
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Flights from Nuremberg (NUE) to Greenville (GSP)
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Flights from Drake Bay (DRK) to Greenville (GSP)
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Flights from Coeur d'Alene (COE) to Greenville (GSP)
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Flights from Bridgeport (BDR) to Greenville (GSP)
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Flights from Leesburg (LEE) to Greenville (GSP)
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Flights from Napa (APC) to Greenville (GSP)
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Flights from Liberia (LIR) to Greenville (GSP)
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Flights from Green River (RVR) to Greenville (GSP)
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Flights from Laughlin (IFP) to Greenville (GSP)
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Flights from Gulf Shores (GUF) to Greenville (GSP)
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Flights from Monastir (MIR) to Greenville (GSP)
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Flights from New York (JFK) to Greenville (GSP)
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Flights from Greenville - Spartanburg
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Flights from Ronne (RNN) to Greenville (GSP)
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Flights from Pilot Point (PIP) to Greenville (GSP)
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Flights to Upstate South Carolina
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Flights from Florence (FLR) to Greenville (GSP)
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Flights from Miami (MIA) to Greenville (GSP)
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Visit Greenville - Spartanburg
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Golden Lanes and Golden Skate
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Lemans Karting
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Museum and Library of Confederate History
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North Hills Shopping Center
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Visit Upstate South Carolina
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Kroc Tennis Complex
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Heritage Green
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Visit Pettigru Street Historic District
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Terrace Shopping Center
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Frankie's Fun Park
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Bob Jones University Museum and Gallery
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Shoeless Joe Jackson Museum
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Cleveland Park
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Green Forest Park
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Prisma Health Greenville Memorial Hospital
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Falls Park on the Reedy
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Beattie House
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Visit Fountain Inn
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Bob Jones University
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Wade Hampton Village Shopping Center
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Ace New Zealand Rental Cars in Fountain Inn
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Car rentals near Greenville Downtown
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Car rental Fountain Inn
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Car rental Mauldin
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Enterprise Rental Cars in Powdersville
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Search Guest Houses in Upstate South Carolina

Change your mind

Treat yourself

Be picky

Check prices for these dates

Our top choices for Upstate South Carolina guest houses

1. Outpost Inn

Learn more about Upstate South Carolina

Explore a world of travel with Expedia