Find Business Hotels in St. Charles, MO

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Check availability on St. Charles Business Hotels

Tonight
Dec 3 - Dec 4
Tomorrow
Dec 4 - Dec 5
This weekend
Dec 5 - Dec 7
Next weekend
Dec 12 - Dec 14

Top St. Charles Business Hotels

Exterior
Holiday Inn Express & Suites Wentzville St Louis West by IHG

Holiday Inn Express & Suites Wentzville St Louis West by IHG

2.5 star property
Wentzville
9.4 out of 10, Exceptional, (831)
"Excellent location, very clean and comfortable, great hot breakfast, and amazing staff!"
United States
Shannon
The price is NT$3,232
NT$3,888 total
includes taxes & fees
Jan 2 - 2026/1/3
Holiday Inn Express & Suites Wentzville St Louis West by IHG
Exterior
Holiday Inn Express St. Louis West - O'Fallon by IHG

Holiday Inn Express St. Louis West - O'Fallon by IHG

2.5 star property
O'Fallon
8.6 out of 10, Excellent, (828)
"The staff was so friendly and helpful! The hotel was exceptionally clean. Breakfast was very good with lots of variety!"
United States
Millie
The price is NT$2,606
NT$3,073 total
includes taxes & fees
Dec 18 - Dec 19
Holiday Inn Express St. Louis West - O'Fallon by IHG
Ballroom
The Wildwood Hotel

The Wildwood Hotel

3.5 star property
Wildwood
9.2 out of 10, Wonderful, (1599)
"The hotel was amazing from the staff to the rooms. Great location as well. Definitely recommend this place if traveling! "
United States
Brandi
The Wildwood Hotel
Premium bedding, desk, iron/ironing board, free cribs/infant beds
Super 8 by Wyndham St Charles

Super 8 by Wyndham St Charles

2.0 star property
St. Charles
8.0 out of 10, Very Good, (1005)
"I'd stay at this place again. "
United States
Suzanne
The price is NT$2,375
NT$2,729 total
includes taxes & fees
Dec 21 - Dec 22
Super 8 by Wyndham St Charles
Exterior
Comfort Suites St Charles - St Louis

Comfort Suites St Charles - St Louis

2.5 star property
St. Charles
8.4 out of 10, Very Good, (1017)
"Nice staff at reception. "
United States
Denise
The price is NT$2,756
NT$3,167 total
includes taxes & fees
Dec 21 - Dec 22
Comfort Suites St Charles - St Louis
Free daily buffet breakfast
Country Inn & Suites by Radisson, St. Charles Historic District

Country Inn & Suites by Radisson, St. Charles Historic District

2.5 star property
St. Charles Historic District
9.4 out of 10, Exceptional, (1001)
"Love this hotel. "
United States
Lisa
The price is NT$3,618
NT$4,158 total
includes taxes & fees
Jan 1 - 2026/1/2
Country Inn & Suites by Radisson, St. Charles Historic District
Lobby
Drury Plaza Hotel St. Louis St. Charles

Drury Plaza Hotel St. Louis St. Charles

3.0 star property
St. Charles
9.6 out of 10, Exceptional, (1002)
"Hotel was very clean."
United States
christine
The price is NT$3,601
NT$4,175 total
includes taxes & fees
Dec 28 - Dec 29
Drury Plaza Hotel St. Louis St. Charles
Lobby
Country Inn & Suites by Radisson, St. Peters, MO

Country Inn & Suites by Radisson, St. Peters, MO

2.5 star property
St. Charles
8.2 out of 10, Very Good, (1000)
"This was an amazing stay"
United States
Madison
The price is NT$3,047
NT$3,502 total
includes taxes & fees
Jan 4 - 2026/1/5
Country Inn & Suites by Radisson, St. Peters, MO
Suite, 1 King Bed, Non Smoking, Refrigerator & Microwave | Premium bedding, pillowtop beds, in-room safe, desk
Best Western Plus The Charles Hotel

Best Western Plus The Charles Hotel

3.0 star property
St. Charles
8.0 out of 10, Very Good, (1000)
"Friendly staff and clean rooms. Great place to stay"
United States
Paul
The price is NT$2,642
NT$3,063 total
includes taxes & fees
Dec 8 - Dec 9
Best Western Plus The Charles Hotel
Lobby
Tru by Hilton St. Charles St. Louis, MO

Tru by Hilton St. Charles St. Louis, MO

2.5 star property
St. Charles
8.6 out of 10, Excellent, (759)
"Great stay. "
United States
Heather
The price is NT$2,738
NT$3,174 total
includes taxes & fees
Dec 28 - Dec 29
Tru by Hilton St. Charles St. Louis, MO
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top St. Charles Hotel Reviews

Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport

10/10 Excellent
"Room was clean and staff courteous. "
Clifford 1-night trip
Posted 12 hours ago
Pear Tree Inn St. Louis Airport

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Frequently asked questions

How much do business-friendly hotels in St. Charles cost?
Expect to pay between NT$2,729 and NT$4,175 per night for business-friendly hotels in St. Charles. Epic deals on stays that cater to work-related guests are a few clicks away on Expedia. These prices were available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
What are the best business-friendly hotels in St. Charles?
Pick from multiple business-friendly hotels in St. Charles that have a total average guest review rating of 8.7. Drury Plaza Hotel St. Louis St. Charles is a favorite with lots of corporate travelers. This 3-stars hotel features amenities such as a swimming pool and a spa tub. Best Western Plus St. Louis Airport Hotel is another recommended option. It has a 2.5-stars rating and conveniences including a swimming pool and pillow top mattresses.
How many business-friendly hotels are there in St. Charles?
St. Charles has 17 hotels that accommodate corporate travelers. Whether your preference is for a location close to the city center or conveniences like dependable WiFi and conference rooms, you'll find the right place on Expedia.
What are the best cheap business-friendly hotels in St. Charles?
Best Western Plus St. Louis Airport Hotel is a great choice for corporate travelers in search of a cost-effective option. It has amenities like a swimming pool and pillow top mattresses. Another economical stay for a work trip is Fairfield Inn & Suites St Louis Westport. Designer toiletries and a barbecue grill are among the conveniences available here. Rates for business-friendly hotels in St. Charles start at NT$2,729 per night, so you'll have more dollars left over to enjoy non-work activities. When it's time to explore the sights of St. Charles, add a few terrific free attractions to your business travel itinerary. James S. McDonnell Prologue Room and Hollywood Casino are popular. This price was available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
Are there any family-friendly hotels in St. Charles that are also business friendly?
Drury Plaza Hotel St. Louis St. Charles is a favorite with both corporate and leisure guests. Complimentary breakfast and WiFi are just a couple of the amenities offered at this 3-stars St. Charles stay. Alternatively, book a break with the kids and work on the road at Best Western Plus St. Louis Airport Hotel. You'll have use of conveniences like complimentary breakfast and a nearby zoo at this top 2.5-stars property. St. Charles has plenty of family-friendly attractions to check out when you're done with work. The kids will love exploring Kokomo Joe's Family Fun Center and Lewis & Clark Boathouse and Nature Center.
Are there any 5-star business-friendly hotels in St. Charles?
While there aren't any 5-star business-friendly hotels in St. Charles, there are some fabulous 4-star options for you to choose from. Take a look at DoubleTree by Hilton St. Louis - Westport, located around 11 kilometers from downtown. This comfortable stay comes with plenty of conveniences, like concierge services and a swimming pool. Renaissance St. Louis Airport Hotel is another 4-star property that caters to those traveling for work. Around 14 kilometers from the center of St. Charles, it features a swimming pool and pillow top mattresses.
Why book your business-friendly hotel in St. Charles with Expedia?
Here at Expedia, we make it our business to help you land the ideal stay at the right price. From luxurious, corporate-friendly retreats to affordable motor inns filled with handy amenities, you'll have your next work trip organized in a few easy clicks.
How can I find cheap business-friendly hotels in St. Charles?
Select the "business friendly" filter, listed under the "traveler experience" heading, to find cheap business-friendly hotels in St. Charles. Then fine-tune your search by your budget and preferred hotel star rating. Staying away from the city center can also help you save.
What is there to do in St. Charles near my business-friendly hotel?
St. Charles has enough sights and experiences to keep you on the go for weeks, beginning with Kokomo Joe's Family Fun Center. James S. McDonnell Prologue Room, Historic Aircraft Restoration Museum and New Jewish Theatre are other terrific attractions. If your business trip gives you time to spare, Hollywood Casino Amphitheatre and Ameristar Casino St. Charles will add the finishing touches to your itinerary.