Find Luxury Hotels in South Carolina Midlands, SC
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Check availability on South Carolina Midlands Luxury Hotels
Our top choices for South Carolina Midlands luxury hotels
The Ballantyne, A Luxury Collection Hotel, Charlotte
The Ballantyne, A Luxury Collection Hotel, CharlotteBallantyne
9.2 out of 10, Wonderful, (1002)
"This hotel is always amazing I find it so welcoming and relaxing. "
David
The price is NT$8,470
NT$9,762 total
includes taxes & fees
Jan 19 - 2026/1/20
9.6 out of 10, Exceptional, (144)
"Easy check in. Great room and our waiter at dinner Nicholas was awesome."
Stephen
The price is NT$9,022
NT$10,105 total
includes taxes & fees
Jan 8 - 2026/1/9
9.2 out of 10, Wonderful, (270)
"Very nice spacious rooms friendly staff"
Duane
The price is NT$5,104
NT$5,717 total
includes taxes & fees
Dec 30 - Dec 31
8.2 out of 10, Very Good, (1001)
"Enjoyed our stay
"
Marie
The price is NT$2,489
NT$2,763 total
includes taxes & fees
Dec 25 - Dec 26
9.4 out of 10, Exceptional, (463)
"A very quiet and beautiful place!"
renee
The price is NT$6,270
NT$7,022 total
includes taxes & fees
Dec 28 - Dec 29
Microtel Inn & Suites by Wyndham Rock Hill/Charlotte Area
Microtel Inn & Suites by Wyndham Rock Hill/Charlotte AreaRock Hill
7.0 out of 10, Good, (1000)
"Staff was very good but the building is in poor condition and the room smelled old and stale, I had to wash all of my clothes after my stay because they stank. "
Jean
The price is NT$1,809
NT$2,007 total
includes taxes & fees
Dec 28 - Dec 29
Inn on the Square, an Ascend Collection Hotel
Inn on the Square, an Ascend Collection HotelUptown Greenwood
9.2 out of 10, Wonderful, (710)
"It was a very clean and beautiful lace to stay. We were there for our honeymoon "
Tracy
The price is NT$3,393
NT$3,767 total
includes taxes & fees
Jan 18 - 2026/1/19
8.4 out of 10, Very Good, (1001)
"Clean rooms and hospitable staff!"
James
The price is NT$3,182
NT$3,564 total
includes taxes & fees
Dec 31 - 2026/1/1
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top South Carolina Midlands Hotel Reviews
La Quinta Inn by Wyndham Columbia SE / Fort Jackson
10/10 Excellent
Explore a world of travel with Expedia
- Adults Only Resorts & in Columbia
- Hotels with a Pool in Cayce
- B&B in South Carolina
- Family Hotels in Blythewood
- Historic Hotels in South Carolina Midlands
- Hotels near Fort Jackson
- Luxury Hotels in South Carolina
- Adults Only Resorts & in South Carolina
- Chalets in South Carolina
- 5 Star Hotels in Columbia
- Hotels near Williams Brice Stadium
- Apartments in South Carolina
- Lodges in South Carolina
- 4 Star Hotels in Five Points
- West Columbia Hotels
- Hotels near Wilson House
- Rv Parks in South Carolina
- Cheap Hotels in South Carolina
- Hotels with smoking rooms in West Columbia
- Hotels with a Pool in Columbia
- Dentsville Hotels
- B&B in Richland County
- Hotel Wedding Venues Hotels in Columbia
- Cheap Hotels in Lugoff
- Hotels with Early Check-in in Columbia
- Hotels with Hot Tubs in Dentsville
- Romantic Hotels in West Columbia
- 5 Star Hotels in Five Points
- Luxury Hotels in Lugoff
- Hotels near William Jennings Bryan Dorn Veterans Affairs Medical Center
- Luxury Hotels in Harbison
- Hotels near Columbia Metropolitan Convention Center
- Casino Hotels in Columbia
- Pet-Friendly Hotels in Lugoff
- Condo Resorts in South Carolina
- Business Hotels in Columbia
- Vacation Homes in South Carolina
- Resorts & Hotels with Spas in Blythewood
- Resorts & Hotels with Spas in Columbia
- Casino Hotels in South Carolina Midlands
- Pet-Friendly Hotels in Downtown Columbia
- Hotels with Free Parking in Blythewood
- Hotels with a Pool in Blythewood
- Historic Hotels in South Carolina
- 4 Star Hotels in Columbia
- Hotels near University of South Carolina
- Hotels near Hilton Field
- Adventure Hotels in Columbia
- 4 Star Hotels in Waverly
- Hotels near Charlie W. Johnson Stadium
- Casino Hotels in South Carolina
- Hotels with a Pool in West Columbia
- Hotels with an Indoor Pool in Downtown Columbia
- Vacation Homes in Columbia
- Visit Earlewood
- Trustus Theatre
- Village at Sandhill Mall
- Allen University
- University of South Carolina
- Five Points Vacations
- Visit Waverly
- Lugoff Vacations
- Columbia Museum of Art
- Visit Five Points
- Sesquicentennial State Park
- Visit South Carolina
- Visit Old Shandon
- Visit Columbia
- Columbia Canal and Riverfront Park
- Robert Mills Historic House and Park
- Riverbanks Zoo and Garden
- Tunnel Vision Mural
- Columbia Place Mall
- Visit Dentsville
- Visit University Hill
- Visit Woodfield
- Mckissick Museum
- Polo Road Ball Park
- Fort Jackson
- West Columbia Riverwalk
- Car rentals near Palmetto Falls Water Park
- Sixt Rental Cars in South Carolina
- Fox Rental Cars Rental Cars in The Vista
- Car rentals near Arsenal Hill
- Car rentals near Colonial Life Arena
- Car rentals near University of South Carolina
- Ok Mobility Rental Cars in Royal Pines Estates
- Car rentals near Downtown Columbia
- Enterprise Rental Cars in Elgin
- Avis Rental Cars in Royal Pines Estates
- Alamo Rent A Car Rental Cars in South Carolina
- Car rentals near Columbia Marionette Theater
- Orlando Rental Cars in South Carolina
- Enterprise Rental Cars in South Carolina