Find Business Hotels in Otay Mesa, CA

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Check availability on Otay Mesa Business Hotels

Tonight
Aug 3 - Aug 4
Tomorrow
Aug 4 - Aug 5
Next weekend
Aug 8 - Aug 10
In two weeks
Aug 15 - Aug 17

Top Otay Mesa Business Hotels

Quality Suites San Diego Otay Mesa
Two single beds with green bedspreads, a small armchair, and a bedside table with a lamp are featured in this cozy space.

Quality Suites San Diego Otay Mesa

2.5 star property
7.2 out of 10, Good, (1005)
"Great location and spacious room "
The price is NT$3,267
NT$3,716 total
includes taxes & fees
Aug 5 - Aug 6
Quality Suites San Diego Otay Mesa
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Welcome to Holiday Inn Express & Suites, featuring a modern design with a lush entrance area and a prominent address sign.

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

2.5 star property
7.8 out of 10, Good, (1412)
"Great stay, close to the Cross Border Xpress "
The price is NT$3,537
NT$4,023 total
includes taxes & fees
Aug 10 - Aug 11
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Sycuan Casino Resort
Relax by the resort pool surrounded by palm trees and a pebble bed.

Sycuan Casino Resort

4.0 star property
9.2 out of 10, Wonderful, (1455)
"We had a wonderful stay, will definitely visit again!"
Sycuan Casino Resort
Days Inn by Wyndham San Diego-East/El Cajon
Relax in this serene space with a large bed, ocean-inspired artwork, and a cozy reading nook by the window.

Days Inn by Wyndham San Diego-East/El Cajon

2.0 star property
7.6 out of 10, Good, (1001)
"Cozy bed, very quiet and convenient"
The price is NT$3,032
NT$3,341 total
includes taxes & fees
Sep 1 - Sep 2
Days Inn by Wyndham San Diego-East/El Cajon
Best Western Santee Lodge
Relax in a spacious room with a large bed, desk, and TV.

Best Western Santee Lodge

2.5 star property
7.8 out of 10, Good, (551)
"I love staying here"
The price is NT$3,625
NT$3,994 total
includes taxes & fees
Sep 1 - Sep 2
Best Western Santee Lodge
Northgate Motel
Two single beds with patterned bedspreads and matching pillows, a nightstand with a telephone and lamp, and framed artwork adorn this cozy sleeping area.

Northgate Motel

2.0 star property
7.6 out of 10, Good, (606)
"I enjoyed how convenient it is from all sorts or restaurants and shopping malls and freeways. For the price it is a pretty good place to rest your head."
Northgate Motel
Super 8 by Wyndham El Cajon/San Diego
Welcome to the reception area, where a friendly staff is available to assist with your stay. A staircase leads to additional floors, and a clock keeps perfect time.

Super 8 by Wyndham El Cajon/San Diego

2.0 star property
7.8 out of 10, Good, (1007)
"Great place "
The price is NT$2,967
NT$3,264 total
includes taxes & fees
Aug 5 - Aug 6
Super 8 by Wyndham El Cajon/San Diego
Best Western Plus La Mesa San Diego
Relax in the stylish lobby, featuring a reception desk, comfortable seating area, and decorative shelving unit.

Best Western Plus La Mesa San Diego

2.5 star property
8.2 out of 10, Very Good, (1007)
"Staff was friendly, hotel was clean and breakfast was great"
The price is NT$3,213
NT$3,534 total
includes taxes & fees
Sep 1 - Sep 2
Best Western Plus La Mesa San Diego
SpringHill Suites by Marriott Chula Vista Eastlake
Relax by the ocean with a clear view from this pool area, surrounded by lounge chairs and tables under the shade of palm trees.

SpringHill Suites by Marriott Chula Vista Eastlake

3.5 star property
9.6 out of 10, Exceptional, (389)
"Clean property and great breakfast!"
The price is NT$4,346
NT$4,789 total
includes taxes & fees
Aug 10 - Aug 11
SpringHill Suites by Marriott Chula Vista Eastlake
Ayres Hotel San Diego South - Chula Vista
Relax in a comfortable seating area surrounded by lush greenery and a bar.

Ayres Hotel San Diego South - Chula Vista

3.0 star property
9.8 out of 10, Exceptional, (1086)
"Prefect stay with the family. Would stay again and recommend to friends. "
The price is NT$7,463
NT$8,224 total
includes taxes & fees
Aug 5 - Aug 6
Ayres Hotel San Diego South - Chula Vista
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Otay Mesa Hotel Reviews

Bay Club Hotel & Marina

Bay Club Hotel & Marina

10/10 Excellent
"The staff is very friendly and helpful. We had a small issue with the AC in our room and they handled it right away and resolved the issue quickly. The rest of the weekend was great with our stay!"
Timothy 2-night trip
Posted 22 hours ago
Bay Club Hotel & Marina

Frequently asked questions

Why book your business-friendly hotel in Otay Mesa with Expedia?
Here at Expedia, our business is to help you land an excellent stay at the right price. From upmarket, corporate-friendly retreats to affordable hotels loaded with amenities, you'll have your next work trip organized in a few quick clicks.
How can I find cheap business-friendly hotels in Otay Mesa?
Select the "business friendly" filter, listed under the "traveler experience" heading, to find cheap business-friendly hotels in Otay Mesa. Then refine your search by your nightly budget. Looking for properties outside the city center is another good way to save.