The Best Resorts & Hotels with Spas in Odessa, FL from NT$3,532 in 2026

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Our top choices for Odessa hotels with a spa

An open doorway leading to a reception area with a dark wood reception desk, a chandelier, and decorative wall sconces.

1. Innisbrook Resort

Palm Harbor

Escape to a resort sanctuary with 12 treatment rooms, tranquil gardens, and 6 outdoor pools where spa indulgence meets golf getaways.

NT$6,928 total

includes taxes & fees

Dec 6 - Dec 7

A lobby with a reception desk, seating area, and artwork.

2. Safety Harbor Resort & Spa Trademark Collection by Wyndham

Safety Harbor

Luxuriate in a waterfront wellness haven with 15 treatment rooms, hot mineral springs, and serene pools for a rejuvenating spa retreat.

NT$6,473 total

includes taxes & fees

Nov 16 - Nov 17

A modern lobby with a large abstract mural, seating area with rattan chairs, and a reception desk.

3. Saddlebrook Resort

Wesley Chapel South

Rejuvenate your spirit at this premier golf resort with 12 treatment rooms and soothing sauna facilities for total wellness.

NT$5,512 total

includes taxes & fees

Nov 24 - Nov 25

A modern spa and salon interior with a central reception desk, seating area, and large windows.

4. Seminole Hard Rock Hotel & Casino Tampa

Tampa

Luxurious spa retreat with 13 treatment rooms and three outdoor pools offers ultimate relaxation getaway.

NT$10,123 total

includes taxes & fees

Dec 7 - Dec 8

A modern lobby with a sofa, potted plants, and vases.

5. Wyndham Grand Clearwater Beach

Clearwater Beach

Escape to this beachfront spa sanctuary with 4 treatment rooms, steam room, and private couples massages.

NT$7,157 total

includes taxes & fees

Nov 9 - Nov 10

A Sleep Inn & Suites hotel with a modern design, featuring a central entrance and multiple floors.

6. Sleep Inn & Suites Tampa South

Sun Bay South

Pamper yourself at this Tampa hotel with a full-service spa, outdoor pool, and hot tub, all conveniently located near Tampa Riverwalk.

NT$4,010 total

includes taxes & fees

Nov 17 - Nov 18

A modern interior with a curved wooden partition, a massage chair, and a sofa set.

7. JW Marriott Tampa Water Street

Downtown Tampa

Serene spa escape with massage treatments and tranquil steam room at this Tampa luxury hotel with a poolside bar.

NT$11,765 total

includes taxes & fees

Nov 23 - Nov 24

A person receiving a manicure in a room with a sofa, a small table with a bottle, and wooden crates labeled 'Carmats' and 'Pall Hores'.

8. Epicurean Hotel, Autograph Collection

Hyde Park

Discover the ultimate pampering oasis at this hotel with a full-service spa, rooftop garden, and outdoor pool for a rejuvenating escape.

NT$7,979 total

includes taxes & fees

Nov 23 - Nov 24

A spa area with a hot tub, candles, and a potted plant.

9. Sandpearl Resort

Clearwater Beach

Discover a coastal sanctuary with couples spa treatments, beach relaxation, and oceanside yoga for a rejuvenating beach escape.

NT$14,617 total

includes taxes & fees

Nov 28 - Nov 29

A hotel room with two beds, a large window with a city view, a sink, and a mirror.

10. Hyatt Regency Clearwater Beach Resort and Suites

Clearwater Beach

Seaside spa sanctuary offers couples' massages and hot stone treatments in 8 serene rooms.

NT$9,618 total

includes taxes & fees

Nov 11 - Nov 12

View all properties

Choose what matters most at spa hotels in Odessa

Pool

Breakfast included

Top Odessa Hotel Reviews

Wyndham Grand Clearwater Beach

Clearwater Beach

10/10 Excellent

Ernesto

JW Marriott Tampa Water Street

Downtown Tampa

10/10 Excellent

Christopher

Epicurean Hotel, Autograph Collection

Hyde Park

10/10 Excellent

Ronald

Sandpearl Resort

Clearwater Beach

10/10 Excellent

This was a beautiful resort. The view of the beach from the Tate restaurant was perfect. The pool area was clean, well laid out, and comfortable. We loved how family friendly this place was. We even felt comfortable leaving our stroller at our chairs while we walked out to the beach. The little touches the resort added made it a relaxing vacation. We went with our 7 month old on our first family vacation. We wish we stayed longer! We would definitely recommend this resort to families and...

megan

Hyatt Regency Clearwater Beach Resort and Suites

Clearwater Beach

10/10 Excellent

stefanie Victoria

Seminole Hard Rock Hotel & Casino Tampa

Tampa

10/10 Excellent

Donald

A multi-story hotel with a covered entrance, outdoor seating area, and a staircase leading to the upper levels.

The Grant Street Inn Dunedin Downtown Historic District, an Ascend Collection Hotel

Downtown Dunedin

10/10 Excellent

KEVIN

Innisbrook Resort

Palm Harbor

10/10 Excellent

ray

A reception area with a wooden reception desk, shelves with products, and a large arched doorway.

The Tampa EDITION

Downtown Tampa

10/10 Excellent

Philip

Safety Harbor Resort & Spa Trademark Collection by Wyndham

Safety Harbor

10/10 Excellent

Tami

A spacious lobby with a high ceiling, a seating area with sofas, and a large window allowing natural light.

Clearwater Beach Marriott Resort & Suites on Sand Key

Sand Key

10/10 Excellent

Ricky

A modern reception area with a large digital screen displaying abstract art, a wooden reception desk, and a seating area with a large potted plant.

JW Marriott Clearwater Beach Resort & Spa

Clearwater Beach

10/10 Excellent

Tricia

A modern lobby with a central seating area, a decorative sculpture, and a variety of plants.

Opal Sol

Clearwater Beach

10/10 Excellent

gilberto

A modern building with a wooden facade, numbered 432 and 434, and a string of lights above the entrance.

Blue Wave Suites

Clearwater Beach

10/10 Excellent

Kimberly

Frequently Asked Questions

Looking to vacation at a spa hotel in Odessa?

Soothe the senses with some time in one of our wonderful spa hotels. Check out the lakeside setting in Odessa - worth a picture or two! Take part in recreational activities such as golfing during your vacation. Spa hotels are a great way to break away from your routine and add a layer of luxury to your weekend away.

What's there to see and do in Odessa?

Enjoy Odessa with a stop at Old McMicky's Farm, Crescent Lake, and Silver Dollar Golf Club. If you have extra time while you’re in the area, you might want to see The Eagles Golf Club and Brooker Creek Headwaters Nature Preserve.

What is a Odessa spa hotel?

Spa hotels in Odessa have full on-site spas and offer services like therapies and a range of beauty treatments. Some also provide a selection of in-room treatments for the ultimate luxury. Spa hotels are a must if you want to give yourself an extra treat while on vacation.

Find Resorts & Hotels with Spas in Odessa, FL

Change your mind

Treat yourself

Be picky

Check prices for these dates

Our top choices for Odessa hotels with a spa

1. Innisbrook Resort

2. Safety Harbor Resort & Spa Trademark Collection by Wyndham

3. Saddlebrook Resort

4. Seminole Hard Rock Hotel & Casino Tampa

5. Wyndham Grand Clearwater Beach

6. Sleep Inn & Suites Tampa South

7. JW Marriott Tampa Water Street

8. Epicurean Hotel, Autograph Collection

9. Sandpearl Resort

10. Hyatt Regency Clearwater Beach Resort and Suites

Choose what matters most at spa hotels in Odessa

Top Odessa Hotel Reviews

Wyndham Grand Clearwater Beach

10/10 Excellent

Frequently Asked Questions

Looking to vacation at a spa hotel in Odessa?

What's there to see and do in Odessa?

What is a Odessa spa hotel?

Explore a world of travel with Expedia