This location is amazing. Close to everything. We walked a few blocks to all our Broadway shows, the subway, movie premiers Central Park, 30 Rock and more. The room was cleaned every day and the staff was super helpful.
The only downside was the Marriott Concierge Room. The Destination Fee charged was supposed to provide free NY activities during our stay. Half way through the stay the list was reduced to 1 activity, that we had already done. Also, don't buy Broadway Show tickets from them. There is an upcharge and if you cannot make the the show and they offer to 'resell' them for you, don't count on it. Buy your tickets directly from the theater. Better pricing and they will exchange.
I would stay here again in a heartbeat, just be wary of the 'Destination' perk promise.