Find Luxury Hotels in New Madrid, MO

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Check availability on New Madrid Luxury Hotels

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Recommended hotels in New Madrid

Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (445)
"Friendly staff clean rooms "
United States
Christopher
The price is NT$3,077
NT$3,484 total
includes taxes & fees
Dec 28 - Dec 29
Hampton Inn Sikeston

Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 star property
Sikeston
8.6 out of 10, Excellent, (443)
"Staff was great. Hotel was clean. Great sleep. "
United States
Jeffrey
The price is NT$2,933
NT$3,321 total
includes taxes & fees
Jan 11 - 2026/1/12
Holiday Inn Express & Suites Sikeston Southwest by IHG

Super 8 By Wyndham Marston

Super 8 By Wyndham Marston
2.0 star property
Marston
7.8 out of 10, Good, (39)
"Great hotel, great staff"
United States
Dmitry
The price is NT$1,818
NT$2,077 total
includes taxes & fees
Dec 22 - Dec 23
Super 8 By Wyndham Marston

Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
2.5 star property
Sikeston
9.4 out of 10, Exceptional, (40)
"THE ROOM WAS SPOTLESS, CLEAN LOBBY, WARM AND LOT OF VARITY BREAKFAST, STAFF IS SO NICE."
United States
AHMAD
The price is NT$3,185
NT$3,606 total
includes taxes & fees
Dec 25 - Dec 26
Fairfield Inn & Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston
3.0 star property
Sikeston
9.0 out of 10, Wonderful, (8)
"Great hotel! Very clean, quiet, plenty of amenities, pool was clean, breakfast in the morning was good with lots of options. I would definitely stay here again. "
United States
Scott
The price is NT$3,721
NT$4,213 total
includes taxes & fees
Dec 25 - Dec 26
TownePlace Suites by Marriott Sikeston

New Orleans Inn Portageville

New Orleans Inn Portageville
2.5 star property
Portageville
8.0 out of 10, Very Good, (726)
"Quiet area and helpful staff. Glad we took a chance on this local hotel while traveling."
United States
Roger
New Orleans Inn Portageville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top New Madrid Hotel Reviews

Frequently asked questions

Are you looking for a luxury hotel for your New Madrid vacation?
Amenities are important when you plan a vacation, so we make it easy to find what you want to make your stay special. If you want an upscale hotel that has a spa, an indoor pool, or luxury bedding, Expedia can help you find the best luxury hotel experience that New Madrid has to offer. New Madrid has some interesting things to see and do including New Madrid Historical Museum and River Ridge Winery, so you might want to take in the local sights during your visit.
When can I expect good weather in New Madrid?
Planning for the weather is a good way to make your trip to New Madrid relaxing and enjoyable, especially when you're splurging. The hottest months are usually July and August with an average temp of 77°F, while the coldest months are January and February with an average of 42°F. Average annual precipitation for New Madrid is 60 inches.
What's there to see and do in New Madrid?
Experience all that New Madrid has to offer when you visit New Madrid Historical Museum, River Ridge Winery, and Mississippi River. If you have spare time during your trip, you might want to make a stop at Hunter-Dawson State Historic Site and Marston Community Center.

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