Apartments in Mississippi County
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Apartments in Mississippi County

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Top cities in Mississippi County

A sunset over a calm lake with tall trees reflected in the water.

Charleston

A tree-lined landscape with a river and fields.

East Prairie

Bertrand

Wyatt

Anniston

Pinhook

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Our top choices for Mississippi County apartments

A cozy cabin-style room with a large L-shaped sectional sofa, a wooden ceiling, and a ladder leading to an upper level.

A wooden cabin interior with a bunk bed, a fan, a sofa, and a staircase.

A wooden cabin interior with a sofa, a coffee table, and a TV mounted on the wall.

A cozy cabin interior with a wooden ceiling, a bed, a chair, a small table, and a television.

1. Close to Reelfoot Lake! Dog-friendly Retreat

Close to Reelfoot Lake! Dog-friendly Retreat

2.5 star property

Tiptonville

Close to Reelfoot Lake! Dog-friendly Retreat

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Top reviews in Mississippi County

An indoor swimming pool with a 3 FT depth marker, a metal ladder, and a tiled floor.

A spacious lobby with a polished floor, seating areas, and modern lighting fixtures.

An outdoor seating area with sofas and planters, surrounded by a building with large windows and a brick wall.

A spacious dining area with high tables and chairs, a bar counter, and large windows providing natural light.

Drury Inn & Suites Sikeston, MO

Sikeston

10/10 Excellent

Food was very good both supper and breakfast. Our room rate was high compared to a couple just checking in before us WHY!! We booked room in September

Judy

Reviewed January 31, 2025Reviewed January 31, 2025

Drury Inn & Suites Sikeston, MO

A Hampton Inn with a stone facade, outdoor seating area, and a fire pit.

A conference room with a large rectangular table, six chairs with patterned upholstery, two modern ceiling lights, a bowl of fruit on the table, and large windows with curtains.

An indoor swimming pool with lounge chairs, a lifeguard stand, and large windows offering a view of the outside.

A hotel lobby with a bar area, seating arrangements, and a large window providing natural light.

Hampton Inn Sikeston

Sikeston

10/10 Excellent

Staff was really nice

Stacey

Reviewed April 10, 2025Reviewed April 10, 2025

Hampton Inn Sikeston

An outdoor seating area with a fire pit, cushioned chairs, and a metal fence.

A hotel lobby with a long counter, multiple seating areas, and a modern chandelier.

A Hampton Inn hotel with a modern design, featuring a well-lit entrance and a clear signage.

A modern hotel lobby with multiple seating areas, a kitchen in the background, and large windows with curtains.

Hampton Inn Union City

Union City

10/10 Excellent

Front desk staff awesome!! Property very nice and clean!

Keri

Reviewed June 9, 2025Reviewed June 9, 2025

Hampton Inn Union City

A buffet with various food items, including omelets and baked goods, served in metal containers.

A Holiday Inn Express & Suites building with a covered entrance, multiple windows, and a parking lot.

An indoor swimming pool with a tiled floor, a lifeguard chair, and a pool ladder.

A reception area with a reception desk, a large wall-mounted sign, and a potted plant.

Holiday Inn Express & Suites Sikeston Southwest by IHG

Sikeston

10/10 Excellent

Everything was Great!😊

Anonymous traveler

Reviewed April 25, 2021Reviewed April 25, 2021

Holiday Inn Express & Suites Sikeston Southwest by IHG

A modern hotel lobby with a reception desk, seating areas, and a large abstract art piece on the wall.

A buffet setup with various food items in metal containers, a patterned wall in the background, and a counter with a glass top.

An indoor swimming pool with clear water, safety signs, and chairs around the pool.

A hotel room with two beds, a desk, and a large window offering a view.

Holiday Inn Express & Suites Union City by IHG

Union City

10/10 Excellent

This hotel was hands down one of the best hotel stays I have had in a long time! Clean! Quiet! Awesome for kids! Breakfast was super clean and delish! Hubs even thought it was legit homemade. Nice scenery to sit outside. Just a great great stay! We will be back even if it is to just enjoy the hotel!

Anonymous traveler

Reviewed October 5, 2023Reviewed October 5, 2023

Holiday Inn Express & Suites Union City by IHG

A modern lobby with a green sofa, two armchairs, a wooden coffee table, and a patterned rug.

A modern hotel with a sign reading "Towneplace Suites by Marriott Fairfield." It features a flat roof, large windows, and a well-lit entrance.

An outdoor bar area with a modern design, featuring a counter, bar stools, and a seating area with chairs.

TownePlace Suites by Marriott Sikeston

Sikeston

10/10 Excellent

I liked the lobby, bar and breakfast areas. The full breakfast buffet was awesome. Super nice room with kitchenette. Staff were great.

Mark

Reviewed October 28, 2026Reviewed October 28, 2026

TownePlace Suites by Marriott Sikeston

A reception area with a reception desk, two blue armchairs, a round table, and a glass door leading outside.

A corridor with a vending machine displaying various beverages and a wall with hanging products.

An outdoor patio area with a blue sectional sofa, an orange ottoman, and black metal chairs.

A large indoor swimming pool with a tiled floor, surrounded by seating areas and tables.

Sleep Inn at Discovery Park of America

Union City

10/10 Excellent

I have not stayed at Sleep Inn before and was super impressed. It was perhaps the cleanest hotel room I’ve seen. The decor was new and linens were pristine. The staff was friendly and knowledgeable about the area. Also, reasonably priced. Would stay again!

Kari

Reviewed December 17, 2022Reviewed December 17, 2022

Sleep Inn at Discovery Park of America

A hotel lobby with a central bar area, multiple dining tables and chairs, large windows, and a patterned carpet.

A reception area with a wooden reception desk, a large painting on the wall, and a potted plant.

An indoor swimming pool with clear water, surrounded by lounge chairs and tables, and large windows providing natural light.

Best Western Plus Sikeston I-55

Sikeston

10/10 Excellent

Very nice comfortable rooms . I would stay there again in the future .

Anonymous traveler

Reviewed December 27, 2018Reviewed December 27, 2018

Best Western Plus Sikeston I-55

A hotel room with a large bed, a desk with a computer, a chair, a window with a view, and a wall-mounted TV.

A modern kitchen with stainless steel appliances, wooden cabinets, and a bright yellow accent wall.

A living room with a sofa, two chairs, a coffee table, a television, and a window with blinds.

A reception area with a sign for 'Travel Inn and Suites' and a counter with a computer and a phone.

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Sikeston

10/10 Excellent

Professional courteous staff, clean, friendly. Nice amount of room-in room!

Anonymous traveler

Reviewed August 30, 2018Reviewed August 30, 2018

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

A hotel room with a bed, a desk with a TV, a chair, a bathroom with a bathtub, and a window with curtains.

A hot tub area with a tiled floor, a wooden deck surrounding the tub, and a view of the sky through large windows.

A living room with two sofas, a coffee table, a TV, and a cabinet.

A modern building with a flat roof and large windows.

Comfort Inn & Suites Sikeston I-55

Sikeston

10/10 Excellent

This is a fantastic hotel! The staff is very wonderful and helpful and thoughtful when my father passed away in November of 2017, part of my family stayed at this hotel. Now I am back here waiting for my mother to arrive for we are going to finally get to see my father who was a Vietnam veteran and was buried at the Bloomfield Cemetery has his headstone put up anyhow I have had some difficulties with a lot of the hotels around here in this one is by far the best I would recommend it to anyone.

Anonymous traveler

Reviewed June 2, 2018Reviewed June 2, 2018

Comfort Inn & Suites Sikeston I-55

A hotel dining area with a long counter, multiple tables, and chairs. There are curtains on the windows, a lamp, and a view of the outdoors.

A hotel room with a large bed, a desk, a chair, and a bedside table.

A hotel room with a dining area, a sofa set, a TV mounted on the wall, and a patterned carpet.

A reception area with a wooden counter, a television, and a sign for 'Quality Inn by Marriott'.

Quality Inn Union City US 51

Union City

10/10 Excellent

The front desk staff was amazing over all of the best places I've ever stayed

Samantha

Reviewed May 16, 2024Reviewed May 16, 2024

Quality Inn Union City US 51

A hotel room with two beds, a wooden headboard, a nightstand with a lamp, and a painting on the wall.

A reception desk with a computer, a framed picture on the wall, and a vase with flowers.

A compact room with a television on a cabinet, a microwave, a small refrigerator, a table, and a chair.

A bathroom with yellow walls, a wooden cabinet, a sink, a mirror, and a hanging towel rack.

La Center Motel

La Center

10/10 Excellent

Good motel. Clean and comfortable room with everything in good working order. Good hot water. Good internet.

Jeffrey

Reviewed October 31, 2026Reviewed October 31, 2026

La Center Motel

A modern hotel room with a large bed, a smaller bed, a desk, and a chair. There is a window with curtains and a painting on the wall.

A spacious lobby with a central atrium, a piano, and a reception desk.

A Days Inn hotel with a brick facade, large windows, and a sign above the entrance.

Days Inn and Suites by Wyndham Sikeston

Sikeston

10/10 Excellent

Jennifer

Reviewed October 3, 2023Reviewed October 3, 2023

Days Inn and Suites by Wyndham Sikeston

A hotel room with a dark wooden desk, a television, a lamp, a chair, and a mirror on the wall.

A building with multiple floors and a flat roof, surrounded by a grassy area with trees.

A parking space marked with a wheelchair accessibility symbol.

A parking lot with a grassy area and trees in the background.

Reelfoot Lake Inn

Tiptonville

10/10 Excellent

The location and the stay was excellent. The hotel management was awesome and very helpful

Anonymous traveler

Reviewed March 28, 2023Reviewed March 28, 2023

Reelfoot Lake Inn

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Hotels near Cape Splash Family Aquatic Center
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Hotels with an Indoor Pool in Sikeston
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Visit Portageville
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Lazy L Safari Park
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Apartments in Mississippi County

Change your mind

Treat yourself

Be picky

Top cities in Mississippi County

Charleston

Find vacation rentals that suit your style

Check prices for these dates

Our top choices for Mississippi County apartments

1. Close to Reelfoot Lake! Dog-friendly Retreat

Top reviews in Mississippi County

Drury Inn & Suites Sikeston, MO

10/10 Excellent

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