The Best Hotels Closest to Mission Hope Cancer Center in Santa Maria for 2026

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Our top choices for Mission Hope Cancer Center hotels

A restaurant with long wooden tables and booths, hanging plants, and a decorative ceiling.

A spacious living area with a grand piano, a chandelier, and a large window offering a view of the outdoors.

A hotel room with two beds, a large window with curtains, a framed picture on the wall, and a lamp on the nightstand.

A hotel room with a kitchenette, a sofa, a coffee table, and a framed picture on the wall.

1. Best Western Plus Big America

2.8 km from Mission Hope Cancer Center

NT$3,422

NT$3,850 total

includes taxes & fees

Nov 15 - Nov 16

A hotel room with a large flat-screen TV mounted on the wall, a bedside table with a lamp, a mirror, and a bed.

A modern bedroom with a bed, a desk, a TV, and a mirror.

A modern living room with a grey sofa, a blue chair, and a TV mounted on the wall.

A spacious living area with a sofa, armchairs, a coffee table, and a kitchen area with a refrigerator and cabinets.

2. Hotel Avanti

2.3 km from Mission Hope Cancer Center

CATYA

NT$2,622

NT$2,950 total

includes taxes & fees

Nov 2 - Nov 3

A courtyard with a fountain, palm trees, and string lights.

A courtyard with a stone fountain, palm trees, and a building with ivy-covered arches.

A bar area with a long wooden counter, multiple stools, and a brick wall backdrop.

A restaurant with a long, curved seating area featuring cushioned booths and tables set for dining.

3. Historic Santa Maria Inn

2.2 km from Mission Hope Cancer Center

Monique

NT$3,640

NT$4,095 total

includes taxes & fees

Nov 8 - Nov 9

A hotel room with a bed, desk, TV, and ceiling fan.

A swimming pool with lounge chairs, palm trees, and a covered area with a vending machine.

A modern kitchen with grey cabinets, a wooden island, a waffle station, and decorative wall art.

A living room with a beige wall, a ceiling fan, a black refrigerator, a brown sofa, a wooden coffee table, and a window with blinds.

4. Quality Inn & Suites Santa Maria

2.9 km from Mission Hope Cancer Center

michael

NT$3,048

NT$3,429 total

includes taxes & fees

Oct 19 - Oct 20

A hotel room with a bed, a wooden dresser, a desk with a chair, and a nightstand with a lamp.

A reception area with a wooden counter, a bulletin board, and a door leading outside.

A motel with multiple rooms, a parking lot, and palm trees.

A hotel room with two beds, a desk, a chair, a TV mounted on the wall, and a window with curtains.

5. Villa Motel

2.4 km from Mission Hope Cancer Center

John

NT$1,954

NT$2,199 total

includes taxes & fees

Oct 21 - Oct 22

A hotel room with two beds, a nightstand with a phone, wall-mounted lamps, and a window with blue curtains.

A clear swimming pool with a red border, surrounded by palm trees and a lounge area with chairs.

A bathroom with a sink, mirror, shower, and towel rack.

A hotel room with a flat-screen TV, a desk with a lamp, a chair, a coffee maker, a microwave, and a small refrigerator.

6. Days Inn by Wyndham Santa Maria

0.8 km from Mission Hope Cancer Center

David

NT$2,452

NT$2,758 total

includes taxes & fees

Nov 15 - Nov 16

A swimming pool with lounge chairs and a small building in the background.

A hotel room with a bed, a mirror, and a green wall.

A hotel reception area with a coffee machine, a microwave, and a potted plant.

A spacious lobby with a large clock, a fireplace, and a pool view.

7. Motel 6 Santa Maria, CA - South

0.5 km from Mission Hope Cancer Center

Amy

NT$2,887

NT$3,248 total

includes taxes & fees

Nov 1 - Nov 2

An outdoor patio with tables and chairs, a bottle of wine, and a glass of red wine.

A modern bar area with a long counter, bar stools, and a wine display.

A two-story building with a sign reading "Wine Store Inn." It features a balcony on the upper floor and a covered outdoor seating area on the ground floor.

A modern lounge area with a wine rack, comfortable seating, and a TV displaying golf.

8. Wine Stone Inn

10.2 km from Mission Hope Cancer Center

DALLAS Cooper

NT$5,481

NT$6,523 total

includes taxes & fees

Oct 18 - Oct 19

A modern cafe with a central serving table, a kitchen area, and a wall with food-related decor.

A Hampton Inn & Suites hotel with a modern design, featuring a stone facade and a welcoming entrance.

A hotel reception area with a modern design, a reception desk, a wall with a welcome sign, and a display case with snacks.

A modern living room with a grey sofa, a pink office chair, a flat-screen TV, and a small desk. There is a kitchen area with a sink and cabinets.

9. Hampton Inn & Suites Santa Maria

3.6 km from Mission Hope Cancer Center

Yesenia

NT$3,829

NT$4,315 total

includes taxes & fees

Nov 1 - Nov 2

A dining table with a plate of food, a glass of white wine, and a bar area in the background.

An outdoor patio with a grill, seating, and a view of a building.

A bar area with a long counter, multiple bottles, glasses, and two large screens.

A modern hotel room with a large bed, a desk with a chair, a television, and a kitchenette.

10. Homewood Suites by Hilton Santa Maria

3.5 km from Mission Hope Cancer Center

Erwin

NT$3,821

NT$4,306 total

includes taxes & fees

Nov 1 - Nov 2

A modern hotel lobby with a long wooden reception desk, multiple bar stools, and pendant lighting.

A reception area with wooden reception desks, a large decorative wall piece, and a seating area with a round table.

A rectangular indoor pool with clear blue water, surrounded by lounge chairs and a sunlit area with large windows.

A hotel with a parking lot, electric vehicle charging stations, and a covered entrance.

11. Fairfield Inn & Suites by Marriott Santa Maria

3.4 km from Mission Hope Cancer Center

Zenny

NT$3,637

NT$4,099 total

includes taxes & fees

Oct 25 - Oct 26

A modern hotel room with a kitchenette, a dining area, and a bedroom.

A covered outdoor patio with two barbecue grills, a concrete floor, and a metal fence.

A reception area with a wooden reception desk, a man and woman at the desk, a dog on a leash, and a luggage cart.

A multi-story hotel with a symmetrical facade, large windows, and a prominent entrance with a blue awning labeled "CANDLEWOOD SUITES".

12. Candlewood Suites Santa Maria by IHG

3.4 km from Mission Hope Cancer Center

John

NT$3,338

NT$3,755 total

includes taxes & fees

Nov 1 - Nov 2

A sign for Solaire Inn & Suites with a clear view of the surrounding palm trees and a street in the background.

A kitchenette with a microwave, a small refrigerator, a chair, and a flat-screen TV mounted on the wall.

A lobby with a reception desk, three black bar stools, an exit sign, framed artwork, and a magazine rack.

A wall with framed certificates and a vase of white roses.

13. Solaire Inn & Suites

3.7 km from Mission Hope Cancer Center

Maria

NT$2,430

NT$2,734 total

includes taxes & fees

Oct 18 - Oct 19

A hotel reception area with a counter, a TV displaying news, framed pictures on the wall, and a sign indicating the hotel name 'motel 6'.

A motel with a swimming pool, multiple rooms, and a parking area.

A row of white front-loading washing machines in a laundry room with a plain wall and a sloped ceiling.

A vending machine with snacks and Coca-Cola bottles.

14. Motel 6 Santa Maria, CA - North

3.4 km from Mission Hope Cancer Center

Tracy

NT$1,923

NT$2,168 total

includes taxes & fees

Nov 15 - Nov 16

A spacious lobby with a high ceiling, multiple seating areas, and a central bar.

A spacious lobby with multiple seating areas, a high ceiling with exposed beams, and a modern design.

A hotel room with a large bed, a sliding glass door to a balcony, a wall-mounted artwork, and a bedside table with a lamp.

A modern interior with seating areas, a high ceiling, and visible structural elements.

15. Radisson Hotel Santa Maria

6.8 km from Mission Hope Cancer Center

Trinh

NT$5,206

NT$5,857 total

includes taxes & fees

Oct 22 - Oct 23

View all properties

Compare popular hotels close to Mission Hope Cancer Center

Property	Property class	Guest rating
Best Western Plus Big America	8.8 Excellent 1,000 reviews	View
Hotel Avanti	8.6 Excellent 502 reviews	View
Historic Santa Maria Inn	8.4 Very good 2,385 reviews	View
Quality Inn & Suites Santa Maria	8.0 Very good 1,000 reviews	View
Villa Motel	8.0 Very good 466 reviews	View

Top Mission Hope Cancer Center Hotel Reviews

Edgewater Inn And Suites

8/10 Good

"Good one, but I don't say ocean view worth the money."

Hotel Avanti

8/10 Good

"I stayed at this little and affortable Motel about a year ago when they finished their renovations. It was FABULOUS.....back then.....my recent stay told another story. They did a wonderful job renovating, however, the upkeep of those renovations is falling short. They put in very nice fixtures and features, but I fear they do not have enough staff and/or resources to keep up with the "modern" renovations that they chose to use. I found sooooooo many problems. Everything from packing tape holding up a bedside wall lamp, to an exobrbident amount of dust on ALL the walls. Window panes were filthy. The bathroom fixtures are all loosening and there is horrible calcium build-up. I could go on and on....I won't. What I did do was TELL THEM. In a kind, respectful and caring manner. I feel for this family. They have such good intentions, but the state of the world doesn't make it easy either. PLEASE let the property, any property you stay at, know about problems. It is the only way they will be addressed. I will stay there again. They thanked me profusley and I was happy to try to help them recover. Shame to spend all that money, only to have it go to waste. Keeping the price affordable to us??? Wow....tough times."

Aloha Inn

8/10 Good

"Ok"

Homewood Suites by Hilton Santa Maria

10/10 Excellent

"Breakfast was very good and service was awesome, also located in a great area!!"

Solaire Inn & Suites

8/10 Good

"The staff and service were very good; the room was clean, and the air conditioning worked well."

Best Western Casa Grande Inn

10/10 Excellent

"Hot tub"

Historic Santa Maria Inn

10/10 Excellent

"Staff was great."

The Agrarian Hotel, BW Signature Collection

10/10 Excellent

"Really great hotel. Spotlessly clean, friendly staff, large, quiet room, great location. Will definitely be back!"

Candlewood Suites Santa Maria by IHG

10/10 Excellent

"Room was as expected. Good price for a nice place to stay."

Frequently asked questions

What's the area like around Mission Hope Cancer Center?

Mission Hope Cancer Center is located in a family-friendly area of Santa Maria known for its array of dining options. If you're looking for a convenient place to stay, check out the 10 hotels and other accommodations you'll find within a mile.

What's the best place to stay near Mission Hope Cancer Center?

Historic Santa Maria Inn is one of the top choices for your stay based on our traveler data, and this hotel offers 2 bars and a restaurant. It's located 1.4 mi (2.2 km) from Mission Hope Cancer Center. Other good options within 5 miles include Villa Motel and Homewood Suites by Hilton Santa Maria.

How many hotels are there near Mission Hope Cancer Center?

Expedia has 10 hotels and other accommodations within a mile from Mission Hope Cancer Center.

If I need to cancel the hotel reservation for my stay near Mission Hope Cancer Center, will I receive a refund?

Yes! The majority of hotel bookings are fully refundable provided that you cancel prior to the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a non-refundable reservation, you might be able to cancel it and be given a refund within 24 hours of your booking. Put your dates in and click on "Search", then use the "fully refundable" filter to review the top deals on offer near Mission Hope Cancer Center.

Where can I learn more about changing or cancelling my trip in the area near Mission Hope Cancer Center?

For more details about changing or cancelling your stay near Mission Hope Cancer Center, head over to our customer service page.

What can I see and do near Mission Hope Cancer Center?

Study the collections at Santa Maria Valley Historical Society, Natural History Museum, or Santa Maria Museum of Flight. You can enjoy live performances at Pacific Conservatory Theatre and Santa Maria Civic Theatre. Children's Resource & Referral (CRR) Discovery Museum, Rancho Bowl, and Santa Maria Fairpark are fun stops for the whole family while you're in town.

Room 1

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Mission Hope Cancer Center hotels

1. Best Western Plus Big America

2. Hotel Avanti

3. Historic Santa Maria Inn

4. Quality Inn & Suites Santa Maria

5. Villa Motel

6. Days Inn by Wyndham Santa Maria

7. Motel 6 Santa Maria, CA - South

8. Wine Stone Inn

9. Hampton Inn & Suites Santa Maria

10. Homewood Suites by Hilton Santa Maria

11. Fairfield Inn & Suites by Marriott Santa Maria

12. Candlewood Suites Santa Maria by IHG

13. Solaire Inn & Suites

14. Motel 6 Santa Maria, CA - North

15. Radisson Hotel Santa Maria

Compare popular hotels close to Mission Hope Cancer Center

Top Mission Hope Cancer Center Hotel Reviews

Edgewater Inn And Suites

Hotel Avanti

Aloha Inn

Homewood Suites by Hilton Santa Maria

Solaire Inn & Suites

Best Western Casa Grande Inn

Historic Santa Maria Inn

The Agrarian Hotel, BW Signature Collection

Candlewood Suites Santa Maria by IHG

Frequently asked questions

Explore a world of travel with Expedia

Find hotels near Mission Hope Cancer Center, Santa Maria from NT$2,168

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Mission Hope Cancer Center hotels

1. Best Western Plus Big America

2. Hotel Avanti

3. Historic Santa Maria Inn

4. Quality Inn & Suites Santa Maria

5. Villa Motel

6. Days Inn by Wyndham Santa Maria

7. Motel 6 Santa Maria, CA - South

8. Wine Stone Inn

9. Hampton Inn & Suites Santa Maria

10. Homewood Suites by Hilton Santa Maria

11. Fairfield Inn & Suites by Marriott Santa Maria

12. Candlewood Suites Santa Maria by IHG

13. Solaire Inn & Suites

14. Motel 6 Santa Maria, CA - North

15. Radisson Hotel Santa Maria

Compare popular hotels close to Mission Hope Cancer Center

Top Mission Hope Cancer Center Hotel Reviews

Edgewater Inn And Suites

Hotel Avanti

Aloha Inn

Homewood Suites by Hilton Santa Maria

Solaire Inn & Suites

Best Western Casa Grande Inn

Historic Santa Maria Inn

The Agrarian Hotel, BW Signature Collection

Candlewood Suites Santa Maria by IHG

Frequently asked questions

Explore a world of travel with Expedia