Find Resorts & Hotels with Spas in Louisiana, MO

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Check availability on Louisiana Resorts & Hotels with Spas

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Top Louisiana Resorts & Hotels with Spas

Indoor pool, sun loungers
Comfort Inn & Suites - Hannibal

Comfort Inn & Suites - Hannibal

2.5 star property
Hannibal
7.6 out of 10, Good, (659)
"Below average facility. Needs some upgrades and could use a good cleaning. Staff was helpful."
United States
JACQUI
The price is NT$2,523
NT$2,991 total
includes taxes & fees
Jan 2 - 2026/1/3
Comfort Inn & Suites - Hannibal
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Louisiana Hotel Reviews

Best Western On The River

Best Western On The River

10/10 Excellent
"Clean and well-maintained. Friendly staff. "
Theresa 2-night trip
Posted 3 days ago
Best Western On The River

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Frequently asked questions

Looking for a spa hotel in Louisiana?
Book one of our fantastic spa hotels and pamper yourself from the moment you arrive. Check out the riverfront in Louisiana - worth a picture or two! Hotels with spas are the perfect way to break out of your routine and add a layer of luxury to your vacation.
What's there to see and do in Louisiana?
Enjoy all that Louisiana has to offer when you visit Mississippi River, Clarksville Riverfront Park, and Clarksville State Game Refuge. If you have a bit of extra time while you're in the area, you might want to check out Ramsey Creek Church.
What is a Louisiana spa hotel?
Spa hotels in Louisiana provide lodging and have an on-site spa offering services such as massages as well as body treatments. Some also offer in-room treatments. Spa hotels are ideal if you are looking for some R&R during your vacation.