A river with a large, rusted metal bridge and a smaller bridge in the background.

Find Resorts & Hotels with Spas in Louisiana, MO

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Check availability on Louisiana Resorts & Hotels with Spas

Our top choices for Louisiana hotels with a spa

A restaurant with a bar area, wooden flooring, checkered tablecloths, and a brick wall.

1. The Eagles Nest Inn

The Eagles Nest Inn
3.0 star property
Louisiana
9.6 out of 10, Exceptional, (28 reviews)
"Cutest place to stay in Louisiana Missouri"
United States
Kimberly
The price is NT$3,536
NT$4,015 total
includes taxes & fees
Nov 23 - Nov 24
The Eagles Nest Inn
A gazebo with a table and benches, surrounded by trees and a body of water.

2. River's Edge Motel

River's Edge Motel
2.0 star property
Louisiana
8.8 out of 10, Excellent, (395 reviews)
"Nice location."
United States
Jeff
The price is NT$2,727
NT$3,096 total
includes taxes & fees
Dec 8 - Dec 9
River's Edge Motel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Choose what matters most at spa hotels in Louisiana

Pool
Breakfast included

Top Louisiana Hotel Reviews

Best Western On The River

Best Western On The River

10/10 Excellent
"The front desk was very helpful."
David 1-night trip
Posted 6 hours ago
Best Western On The River
Baymont by Wyndham Hannibal

Baymont by Wyndham Hannibal

10/10 Excellent
"The room is small. The water pressure in the shower is very low for the hot water. The shower is low. The toilet is low. All of the lights work properly. Everything works good."
Edward 1-night trip
Posted 2 days ago
Baymont by Wyndham Hannibal

Frequently asked questions

Looking for a spa hotel in Louisiana?
Book one of our fantastic spa hotels and pamper yourself from the moment you arrive. Check out the riverfront in Louisiana - worth a picture or two! Hotels with spas are the perfect way to break out of your routine and add a layer of luxury to your vacation.
What's there to see and do in Louisiana?
Enjoy all that Louisiana has to offer when you visit Mississippi River, Clarksville State Game Refuge, and Clarksville Riverfront Park. If you have a bit of extra time while you're in the area, you might want to check out Ramsey Creek Church.
What is a Louisiana spa hotel?
Spa hotels in Louisiana provide lodging and have an on-site spa offering services such as massages as well as body treatments. Some also offer in-room treatments. Spa hotels are ideal if you are looking for some R&R during your vacation.

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