Photo by Caroline Nunez

Find Boutique Hotels in Hartsville, SC

Start date: Check-in selected.
To Date
End date: Check-out
  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check availability on Hartsville Boutique Hotels

Next weekend
In two weeks
No exact matches found, but these alternatives could be just right

Recommended hotels in Hartsville

Hampton Inn & Suites Hartsville

Hampton Inn & Suites Hartsville
2.5 star property
Hartsville
9.2 out of 10, Wonderful, (479)
"Staff was very friendly and accommodating!! Rooms were very clean! "
United States
Julia
The price is NT$3,841
NT$4,301 total
includes taxes & fees
Jan 9 - 2026/1/10
Hampton Inn & Suites Hartsville

Fairfield Inn by Marriott Hartsville

Fairfield Inn by Marriott Hartsville
2.5 star property
Hartsville
8.6 out of 10, Excellent, (681)
"very friendly older property but clean"
United States
Tamiko
The price is NT$2,645
NT$2,963 total
includes taxes & fees
Jan 17 - 2026/1/18
Fairfield Inn by Marriott Hartsville

The Landmark Inn

The Landmark Inn
2.5 star property
Hartsville
7.0 out of 10, Good, (315)
"Great staff"
United States
Thomas
The price is NT$2,263
NT$2,645 total
includes taxes & fees
Dec 28 - Dec 29
The Landmark Inn

The Mantissa Hotel

The Mantissa Hotel
3.0 star property
Hartsville
9.2 out of 10, Wonderful, (271)
"Very nice spacious rooms friendly staff"
United States
Duane
The price is NT$5,092
NT$5,703 total
includes taxes & fees
Jan 4 - 2026/1/5
The Mantissa Hotel

Quality Inn Hartsville

Quality Inn Hartsville
2.5 star property
Hartsville
6.0 out of 10, (330)
"Lady at desk was plesant and helpful. Sstart3ed to ask for our money back"
United States
Cynthia
The price is NT$1,950
NT$2,206 total
includes taxes & fees
Jan 13 - 2026/1/14
Quality Inn Hartsville

Park Inn by Radisson Florence, SC

Park Inn by Radisson Florence, SC
2.5 star property
Florence
9.0 out of 10, Wonderful, (2209)
"Breakfast was great, room very clean ."
United States
Leann
The price is NT$2,659
NT$2,978 total
includes taxes & fees
Jan 11 - 2026/1/12
Park Inn by Radisson Florence, SC

Comfort Inn & Suites Florence Center Area

Comfort Inn & Suites Florence Center Area
2.5 star property
Florence
9.2 out of 10, Wonderful, (1174)
"Great location, friendly staff. "
United States
Defelicio
The price is NT$3,073
NT$3,441 total
includes taxes & fees
Jan 11 - 2026/1/12
Comfort Inn & Suites Florence Center Area

Howard Johnson by Wyndham Florence

Howard Johnson by Wyndham Florence
2.0 star property
Florence
8.6 out of 10, Excellent, (2518)
"Great room and staff."
United States
LEE
The price is NT$1,980
NT$2,218 total
includes taxes & fees
Dec 28 - Dec 29
Howard Johnson by Wyndham Florence
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Hartsville Hotel Reviews

Frequently asked questions

What's there to see and do in Hartsville?
Enjoy the great selection of restaurants while you're in the area. Attractions and activities to experience around Hartsville include Neptune Island Waterpark, Hartsville Museum, and Kalmia Gardens. You might also want to consider exploring Darlington Raceway, The Traces Golf Club, and Palmetto Shores Lake while you're here.
What kind of weather should I plan for when I travel to Hartsville?
Getting an idea of what to expect from the weather in Hartsville is important when you plan your trip. The hottest months are usually July and August with an average temp of 78°F, while the coldest months are January and February with an average of 49°F. Average annual precipitation for Hartsville is 52 inches.
What's the best way to get to my boutique hotel in Hartsville?
You have a few options for getting to Hartsville. The nearest major airport is Florence, SC (FLO-Florence Regional), which is located 23.3 mi (37.5 km) from the heart of the city. If you'd like to explore around the area, you may want a rental car for your journey.

Explore a world of travel with Expedia