Florida Keys 5 Stars Hotels

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Check availability on Florida Keys 5 Star Hotels

Our top choices for Florida Keys 5-star hotels

Balcony

Cheeca Lodge & Spa

Cheeca Lodge & Spa
5.0 star property
Matecumbe
9.2 out of 10, Wonderful, (1,298 reviews)
"Great staff and beautiful property "
United States
Julie
The price is NT$11,245
NT$14,992 total
includes taxes & fees
Apr 12 - Apr 13
Cheeca Lodge & Spa
On the beach, sun loungers, beach umbrellas, beach towels

Isla Bella Beach Resort & Spa

Isla Bella Beach Resort & Spa
5.0 star property
Marathon
9.2 out of 10, Wonderful, (1,102 reviews)
"Ocean was stunning from our room and the staff was always helpful; the food was delicious no matter if you ate at the bar or the incredible ocean side restaurant. Overall the Isla Bella did not disappoint and was the perfect escape."
United States
Ryan
The price is NT$16,086
NT$20,332 total
includes taxes & fees
Apr 16 - Apr 17
Isla Bella Beach Resort & Spa
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Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Florida Keys.
Reefhouse Resort & Marina

Reefhouse Resort & Marina

103800 Overseas Hwy Key Largo FL
The price is NT$12,135 per night from Apr 12 to Apr 13
NT$12,135
NT$14,933 total
Apr 12 - Apr 13
includes taxes & fees
9.2/10 Wonderful! (1,386 reviews)
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Florida Keys

Snorkel crystal-clear waters teeming with colorful fish, then feast on fresh-caught lobster at a laid-back waterfront shack. Drive the scenic Overseas Highway, stopping at Key West's Ernest Hemingway Home and Dry Tortugas National Park for island adventures.

See all hotels in Florida Keys
Higgs Beach showing a sandy beach and tropical scenes as well as a large group of people

Top Florida Keys Hotel Reviews

Isla Bella Beach Resort & Spa

Isla Bella Beach Resort & Spa

10/10 Excellent
"Perfect stay"
John 8-night trip
Posted 2 days ago
Isla Bella Beach Resort & Spa
Cheeca Lodge & Spa

Cheeca Lodge & Spa

6/10 Okay
"We did not use the spa services, we may have been able to barely see a small portion of the ocean out a window"
Mike 2-night trip
Posted 4 days ago
Cheeca Lodge & Spa

Frequently asked questions

How much does it cost to stay in a 5-star hotel in Florida Keys?
You can find several pricing options for a 5-star hotel in Florida Keys on Expedia. The amount you pay will depend on your travel dates, length of your trip and other factors. Compare all of the available accommodations for your chosen dates and make use of our pricing and other filters to score the ideal upscale stay.

  • Search for the lowest price per night from NT$11,799

What makes a hotel 5 stars in Florida Keys?
From gourmet restaurants and 24-hour gyms to pools and deluxe bedding, the 5-star experience in Florida Keys is all about comfort and indulgence. But it calls for more than just top-notch perks to earn a 5-star rating. Stays must also provide outstanding guest-focused services like in-room massage treatments, on-site laundry and dry cleaning and 24/7 room service.
Are there any 5-star all-inclusive resorts in Florida Keys?
Find an indulgent escape that includes your lodging, meals, drinks and entertainment in Florida Keys with Expedia's filters. Search for hotels rated 5 stars and click on the "All inclusive" filter. Double-check what's included in the upfront price. This way, you'll be ready to maximize all the premium perks from the moment you arrive.

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