South Central Houston 4 Stars Hotels
Change your mind
Book hotels with free cancellation
Be picky
Search almost a million properties worldwide
Check availability on South Central Houston 4 Star Hotels
Compare South Central Houston 4 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

Hilton Houston Plaza/Medical Center
Hilton Houston Plaza/Medical Center
8.4 out of 10, Very Good, (1427)
The price is NT$3,131
NT$3,698 total
includes taxes & fees
Jul 20 - Jul 21

DoubleTree by Hilton Houston Medical Center Hotel & Suites
DoubleTree by Hilton Houston Medical Center Hotel & Suites
8.2 out of 10, Very Good, (375)
The price is NT$3,114
NT$3,643 total
includes taxes & fees
Jul 20 - Jul 21

Hotel Zaza Houston Museum District
Hotel Zaza Houston Museum District
9.0 out of 10, Wonderful, (1715)
The price is NT$5,640
NT$7,783 total
includes taxes & fees
Aug 5 - Aug 6

The Westin Houston Medical Center/Museum District
The Westin Houston Medical Center/Museum District
9.0 out of 10, Wonderful, (1012)
The price is NT$4,182
NT$5,205 total
includes taxes & fees
Jul 20 - Jul 21

InterContinental Houston by IHG
InterContinental Houston by IHG
9.2 out of 10, Wonderful, (1011)
The price is NT$4,154
NT$5,295 total
includes taxes & fees
Jul 20 - Jul 21

Houston Marriott Medical Center/Museum District
Houston Marriott Medical Center/Museum District
9.0 out of 10, Wonderful, (1006)
The price is NT$4,419
NT$6,101 total
includes taxes & fees
Aug 8 - Aug 9

Luxury Med Center Fully Equipped King Sized Bed Condos
Luxury Med Center Fully Equipped King Sized Bed Condos
8.4 out of 10, Very Good, (92)
The price is NT$4,251
NT$7,733 total
includes taxes & fees
Jul 9 - Jul 10

Prime EADO 4 BR Downtown Houston
Prime EADO 4 BR Downtown Houston
Save an average of 15% on thousands of hotels when you're signed in
Recent reviews of South Central Houston hotels
Recent reviews of South Central Houston hotels

InterContinental Houston by IHG
5/5 Excellent
"The hotel was beautiful from the front lobby to the restaurants. Staff went above and beyond. "
A verified traveler stayed at InterContinental Houston by IHG
Posted 3 days ago
Explore a world of travel with Expedia
Explore a world of travel with Expedia
South Central Houston Hotels by Star Rating
Stay near popular South Central Houston attractions
- Hotels near MD Anderson Cancer Center
- Hotels near Rice University
- Hotels near University of Houston
- Hotels near Houston Zoo
- Hotels near Houston Natural Science Museum
- Hotels near Children's Museum of Houston
- Hotels near Houston Methodist Hospital
- Hotels near Texas Southern University
- Hotels near Houston Museum of Fine Arts
- Hotels near Hermann Park
- Hotels near Main Street Theater - Rice Village
- Hotels near Texas Children's Hospital
- Hotels near Memorial Hermann Hospital
- Hotels near Continental Club
- Hotels near Midtown Arts and Theater Center Houston
- Hotels near Miller Outdoor Theater
- Hotels near Rice Stadium
- Hotels near Harris Health System - Ben Taub General Hospital
- Hotels near Chi St. Lukes Health Baylor College Of Medicine Medical Center
- Hotels near Houston Contemporary Arts Museum
Explore more hotels
- Wanderstay Houston Hostel
- MyCrib Houston Hostel
- La Maison in Midtown an urban B&B
- Southmore Boulevard Motel
- Modern Cozy Home with King Bed
- Scott Inn Suites - Downtown Houston
- Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only
- Luxurious 3 Bed3 Bath Near Downtown Houston
- EaDo Signature
More ways to book
Expedia's Latest Trends
Hotels
Flights
Flights from Incheon (ICN) to Sydney (SYD)Flights from San Jose (SJC) to Taoyuan City (TPE)Flights from Taoyuan City (TPE) to Nice (NCE)Flights from Shuishang (CYI) to Huxi (MZG)Flights from Sydney (SYD) to Narita (NRT)Flights from Xincheng (HUN) to Bangkok (BKK)Flights from Taoyuan City (TPE) to Lyudao (GNI)
Packages