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Check prices for these dates

Tonight
Feb 14 - Feb 15
Tomorrow
Feb 15 - Feb 16
Next weekend
Feb 20 - Feb 22
In two weeks
Feb 27 - Mar 1

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Our top choices for Sanctuary hotels

Interior entrance

Allure Suites

Allure Suites
3.0 star property
27.2 km from Sanctuary
7.8 out of 10, Good, (1,004 reviews)
"The room was very clean, spacious and the kitchenette was nice! The staff was also very helpful and really nice!!"
United States
Kristin
The price is NT$3,615
NT$4,031 total
includes taxes & fees
Feb 28 - Mar 1
Allure Suites
Balcony view

OYO Waterfront Hotel - Cape Coral/Fort Myers, FL

OYO Waterfront Hotel - Cape Coral/Fort Myers, FL
2.5 star property
25.2 km from Sanctuary
5.8 out of 10, (1,003 reviews)
"Great stay staff was great . Lake veiw was beautifully i definitely rerent rm 207. Has beautiful restaurant next door work price and ambience. "
United States
Rachel
The price is NT$2,940
NT$3,530 total
includes taxes & fees
Feb 19 - Feb 20
OYO Waterfront Hotel - Cape Coral/Fort Myers, FL
Lobby lounge

Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral

Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral
3.0 star property
30.1 km from Sanctuary
8.6 out of 10, Excellent, (820 reviews)
"Quiet, clean and accommodating staff."
United States
George
The price is NT$4,066
NT$4,534 total
includes taxes & fees
Mar 1 - Mar 2
Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral
Lobby

Tween Waters Island Resort & Spa

Tween Waters Island Resort & Spa
3.0 star property
3.7 km from Sanctuary
8.6 out of 10, Excellent, (1,004 reviews)
"Lovely location, pools and restaurants."
United States
Linda
The price is NT$11,444
NT$13,860 total
includes taxes & fees
Mar 6 - Mar 7
Tween Waters Island Resort & Spa
House (3 Bedrooms) | Interior

Bike to Dtwn: Home w/ Hot Tub & BBQ in Cape Coral

Bike to Dtwn: Home w/ Hot Tub & BBQ in Cape Coral
3.0 star property
23.1 km from Sanctuary
The price is NT$3,081
NT$10,733 total
includes taxes & fees
Feb 15 - Feb 16
Bike to Dtwn: Home w/ Hot Tub & BBQ in Cape Coral
BBQ/picnic area

Matlacha on Shoreview

Matlacha on Shoreview
2.0 star property
20.2 km from Sanctuary
9.6 out of 10, Exceptional, (232 reviews)
"Beautiful resort, great communication, super clean "
United States
Ronald
The price is NT$3,109
NT$5,568 total
includes taxes & fees
Mar 13 - Mar 14
Matlacha on Shoreview
Floating Coconut Cottage Houseboat | Terrace/patio

Latitude 26 Waterfront Resort & Marina

Latitude 26 Waterfront Resort & Marina
3.0 star property
22 km from Sanctuary
8.6 out of 10, Excellent, (943 reviews)
"Beautiful clean room friendly staff beautiful scenery"
United States
Cassie
The price is NT$10,192
NT$11,364 total
includes taxes & fees
Mar 15 - Mar 16
Latitude 26 Waterfront Resort & Marina
View from room

La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway
3.0 star property
19.9 km from Sanctuary
8.2 out of 10, Very Good, (1,024 reviews)
"Clean room, conveniently located close to Sanibel, comfortable accommodations "
United States
Stacey
The price is NT$6,256
NT$6,976 total
includes taxes & fees
Mar 15 - Mar 16
La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway
Exterior

TriLuxe Inn & Studios

TriLuxe Inn & Studios
2.0 star property
22.7 km from Sanctuary
8.2 out of 10, Very Good, (19 reviews)
"Great mattress, enjoyed the recliners, we prefer no doors on the closet making it fast & easy to access our wardrobe, liked the Roku TV, liked the induction stove top and drainer for washing our dishes daily as opposed to having a dishwasher. "
United States
Bobbi
The price is NT$3,367
NT$4,771 total
includes taxes & fees
Feb 16 - Feb 17
TriLuxe Inn & Studios
3 restaurants, breakfast, lunch, dinner served; Italian cuisine

Lani Kai Beachfront Resort

Lani Kai Beachfront Resort
3.5 star property
21.8 km from Sanctuary
9.0 out of 10, Wonderful, (1,234 reviews)
"Nice place to stay"
United States
Denise
The price is NT$12,230
NT$14,337 total
includes taxes & fees
Feb 16 - Feb 17
Lani Kai Beachfront Resort
Deluxe Studio Suite | Terrace/patio

White Orchid Apartments

White Orchid Apartments
2.0 star property
20 km from Sanctuary
8.2 out of 10, Very Good, (50 reviews)
"Clean, easy access, quiet, best bed and sheets ever!!!"
United States
Brooke
The price is NT$3,898
NT$5,363 total
includes taxes & fees
Feb 16 - Feb 17
White Orchid Apartments
Exterior

Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG
2.5 star property
23.1 km from Sanctuary
9.4 out of 10, Exceptional, (1,002 reviews)
"Very clean & friendly staff. "
United States
denise
The price is NT$5,968
NT$6,654 total
includes taxes & fees
Feb 22 - Feb 23
Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG
Exterior

Sanibel Inn

Sanibel Inn
3.0 star property
East End, 13.8 km from Sanctuary
9.0 out of 10, Wonderful, (1,002 reviews)
"Perfect place if you are looking for a quiet and safe environment! "
United States
Rachelle
The price is NT$18,186
NT$22,276 total
includes taxes & fees
Feb 15 - Feb 16
Sanibel Inn
Grand Studio Suite, Kitchenette | Desk, laptop workspace, free WiFi, bed sheets

Lazy Cuckoo Inn

Lazy Cuckoo Inn
2.0 star property
22.1 km from Sanctuary
8.8 out of 10, Excellent, (248 reviews)
"Room was spotless equipped with everything you could need bed was comfy Frank was very helpful"
United States
Judith
The price is NT$3,647
NT$5,083 total
includes taxes & fees
Feb 16 - Feb 17
Lazy Cuckoo Inn
Private beach nearby, motor boating, fishing

MALU LANI Inn & Marina

MALU LANI Inn & Marina
2.5 star property
24.7 km from Sanctuary
The price is NT$6,649
NT$10,244 total
includes taxes & fees
Feb 16 - Feb 17
MALU LANI Inn & Marina
Terrace/patio

Hilton Garden Inn Ft Myers

Hilton Garden Inn Ft Myers
3.0 star property
29.5 km from Sanctuary
8.8 out of 10, Excellent, (1,001 reviews)
"Great place"
United States
Brian
The price is NT$6,508
NT$7,256 total
includes taxes & fees
Mar 8 - Mar 9
Hilton Garden Inn Ft Myers
View from property

Marriott Sanibel Harbour Resort & Spa

Marriott Sanibel Harbour Resort & Spa
4.0 star property
15.6 km from Sanctuary
8.4 out of 10, Very Good, (1,004 reviews)
"Nice room and perfect location"
United States
Matthias
The price is NT$11,197
NT$13,585 total
includes taxes & fees
Feb 22 - Feb 23
Marriott Sanibel Harbour Resort & Spa
Exterior

Pink Shell Beach Resort and Marina

Pink Shell Beach Resort and Marina
4.0 star property
20.4 km from Sanctuary
9.4 out of 10, Exceptional, (1,266 reviews)
"Great place to stay"
United States
Robyn
The price is NT$19,759
NT$24,097 total
includes taxes & fees
Feb 17 - Feb 18
Pink Shell Beach Resort and Marina
Exterior

Homewood Suites by Hilton - Fort Myers

Homewood Suites by Hilton - Fort Myers
3.0 star property
30.9 km from Sanctuary
9.2 out of 10, Wonderful, (1,000 reviews)
"Great room and the breakfast was delicious "
United States
Jackeline
The price is NT$7,038
NT$7,847 total
includes taxes & fees
Feb 22 - Feb 23
Homewood Suites by Hilton - Fort Myers
Aerial view

DiamondHead Beach Resort

DiamondHead Beach Resort
3.5 star property
22.3 km from Sanctuary
9.2 out of 10, Wonderful, (1,058 reviews)
"Very lovely stay!!"
United States
Elizabeth
DiamondHead Beach Resort
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Sanctuary

Find the best Sanctuary areas and neighborhoods for the activities you enjoy most.

West End

While visiting West End, you might make a stop by sights like J. N. Ding Darling National Wildlife Refuge and Bowman's Beach.

Mid Island

While visiting Mid Island, you might make a stop by sights like Periwinkle Way and Sanibel Island Southern Beach.

East End

While visiting East End, you might make a stop by sights like Sanibel Island Northern Beach and Sanibel Island Lighthouse.

Periwinkle Way which includes cycling as well as an individual femail

Beachview Country Club Estates

If you're spending some time in Beachview Country Club Estates, Periwinkle Way and Sanibel Island Golf Club are top sights worth seeing.

Shell Harbor

Though Shell Harbor might not have many top sights, you can venture to the surrounding area to see attractions like Sanibel Moorings Botanical Gardens and Sanibel Sea School.

Top Sanctuary Hotel Reviews

Lani Kai Beachfront Resort

Lani Kai Beachfront Resort

10/10 Excellent
"Everything about this hotel was excellent. The room was fresh, the staff genuinely positive and welcoming. The multiple restaurants and bars available onsite made us feel like we didn’t need to go anywhere else. Right on the beach and every room had a beach view! We’ll be going back for sure!"
Robert 3-night trip
Posted 19 hours ago
Lani Kai Beachfront Resort

Frequently asked questions

What is Sanctuary like?
Travelers are sure to enjoy a stay in Sanibel's Sanctuary neighborhood. Consider a visit to J. N. Ding Darling National Wildlife Refuge as part of your Sanctuary travel plans.
How many hotels are there in the Sanctuary area?
When you want to find places to stay in Sanibel, start by booking one of Expedia's 9 hotels and other accommodations in Sanctuary.
If I need to cancel my hotel reservation in Sanctuary, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable as long as you cancel before the hotel's cancellation deadline, which often is within 24-48 hours of your check-in date. If your reservation is non-refundable, it might still be possible to cancel it and get a refund within a 24-hour period of booking. Enter your dates, click on "Search", then you can use the "fully refundable" filter to review top deals in Sanctuary.
Where can I learn more about changing or cancelling my trip to Sanctuary?
For more information about updating your trip to Sanctuary or cancelling it, click here.
What is there to do around this Sanibel neighborhood?
J. N. Ding Darling National Wildlife Refuge is an attraction you might want to check out while you're in Sanctuary. Castaways Marina and Blind Pass Beach are also worth a visit when you're out sightseeing in Sanibel.

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