A bench, a bicycle, and a lake surrounded by trees.

Best Western Upstate South Carolina hotels

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Aug 19 - Aug 20
Tomorrow
Aug 20 - Aug 21
This weekend
Aug 21 - Aug 23
Next weekend
Aug 28 - Aug 30

Our top choices for Upstate South Carolina Best Western

1. Best Western Spartanburg Northwest

Best Western Spartanburg Northwest
Spartanburg
United States
Porsche
NT$2,815
NT$3,187 total
includes taxes & fees
Aug 30 - Aug 31
Best Western Spartanburg Northwest

2. Best Western Travelers Rest Greenville

Best Western Travelers Rest Greenville
Travelers Rest
United States
Liz
NT$3,518
NT$3,870 total
includes taxes & fees
Aug 31 - Sep 1
Best Western Travelers Rest Greenville

3. Best Western Seneca-Clemson

Best Western Seneca-Clemson
Seneca
United States
Michelle
NT$3,086
NT$3,394 total
includes taxes & fees
Aug 21 - Aug 22
Best Western Seneca-Clemson

4. Best Western Spartanburg I-26

Best Western Spartanburg I-26
Spartanburg
United States
Francisco
NT$2,679
NT$2,974 total
includes taxes & fees
Aug 26 - Aug 27
Best Western Spartanburg I-26
View all properties
Save an average of 15% on thousands of hotels when you're signed in

Top Upstate South Carolina Hotel Reviews

Hilton Greenville

Hilton Greenville

10/10 Excellent
"Great location, staff, condition. Thanks. I’ll be back"
James 1-night trip
Posted 3 hours ago
Hilton Greenville
Embassy Suites Greenville Golf Resort & Conference Center

Embassy Suites Greenville Golf Resort & Conference Center

10/10 Excellent
"Loved it. Always lovely and the staff are wonderful. Clean and great breakfast as usual."
Jennifer 1-night trip
Posted 8 hours ago
Embassy Suites Greenville Golf Resort & Conference Center
Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center

10/10 Excellent
"This was the most enjoyable stay I’ve had in Clemson! Everything was great. I will stay here again next year!"
James 2-night trip
Posted 10 hours ago
Best Western Plus Clemson Hotel & Conference Center
The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson

10/10 Excellent
"N/a"
Kelly 2-night trip
Posted 11 hours ago
The Shepherd Hotel Downtown Clemson
Comfort Inn Greenville - Haywood Mall

Comfort Inn Greenville - Haywood Mall

8/10 Good
"Would stay again food was okay for breakfast and rooms were nice"
Russ 1-night trip
Posted 13 hours ago
Comfort Inn Greenville - Haywood Mall
Inn @ Clemson

Inn @ Clemson

8/10 Good
"Close to campus, staff was amazing, amenities were ehh, breakfast was small, gym was out of service."
Daniela 3-night trip
Posted 1 day ago
Inn @ Clemson
Comfort Inn & Suites Clemson - University Area

Comfort Inn & Suites Clemson - University Area

10/10 Excellent
"Stayed during Clemson move in and it was great. Very reasonable price, clean room and good breakfast. Also super close to campus!"
Beth 2-night trip
Posted 2 days ago
Comfort Inn & Suites Clemson - University Area
Hotel Hartness

Hotel Hartness

10/10 Excellent
"Amazing!"
Kim 1-night trip
Posted 2 days ago
Hotel Hartness
Best Western Plus Greenville I-385 Inn & Suites

Best Western Plus Greenville I-385 Inn & Suites

8/10 Good
"Checking in was odd because we booked ahead of time: but still required a card to check in. WiFi password was confusing until we figured out, beds were a little firm for my liking but the pillows were great. Room was clean and housekeeping was nice; parking kinda sucks tho. We didn’t eat the breakfast or use the pool/fitness center. We typically enjoyed our time in the city. But, it’s very centrally located to a lot, most things were only 10 mins away!"
shamar 5-night trip
Posted 2 days ago
Best Western Plus Greenville I-385 Inn & Suites

Explore a world of travel with Expedia