Photo by Michelle Hendrix
Best Western Upstate South Carolina hotels
- Change your mindBook hotels with free cancellation
- Be pickySearch almost a million properties worldwide
Check prices for these dates
Compare rooms and suites by Best Western in Upstate South Carolina with rates, reviews, and availability. Most hotels are fully refundable.

Best Western Greenville Airport Inn
Greenville
7.6 out of 10, Good, (1009)
The price is NT$2,266
NT$2,493 total
includes taxes & fees
Dec 2 - Dec 3

Best Western Seneca-Clemson
Seneca
8.4 out of 10, Very Good, (636)
The price is NT$2,802
NT$3,082 total
includes taxes & fees
Dec 21 - Dec 22

Best Western Spartanburg Northwest
Spartanburg
8.2 out of 10, Very Good, (814)
The price is NT$2,642
NT$2,932 total
includes taxes & fees
Dec 21 - Dec 22

Best Western Travelers Rest Greenville
Travelers Rest
7.6 out of 10, Good, (1004)
The price is NT$2,935
NT$3,228 total
includes taxes & fees
Dec 31 - 2026/1/1
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Top Upstate South Carolina Hotel Reviews

La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.
10/10 Excellent
Explore a world of travel with Expedia
Upstate South Carolina Hotels by Brand
Hotels in Upstate South Carolina Neighborhoods
- Greenville Downtown Hotels
- West End Hotels
- Green Avenue Hotels
- Payne-Logan Hotels
- Pettigru Street Historic District Hotels
- Woodside Cotton Mill Village Historic District Hotels
- Hampton-Pinckney Historic District Hotels
- Turtlehead Hotels
- Colonel Elias Earle Historic District Hotels
- Chickasaw Point Hotels
Hotels near popular Upstate South Carolina Attractions
- Hotels near Clemson University
- Hotels near Bon Secours Wellness Arena
- Hotels near Haywood Mall
- Hotels near Memorial Stadium
- Hotels near Prisma Health Greenville Memorial Hospital
- Hotels near Falls Park on the Reedy
- Hotels near The Peace Center
- Hotels near Greenville Convention Center
- Hotels near Lake Keowee
- Hotels near BMW Performance Center
More Hotel Options in Upstate South Carolina
- Adults Only Resorts & Hotels in Upstate South Carolina
- Adventure Hotels in Upstate South Carolina
- Beach Hotels in Upstate South Carolina
- Boutique Hotels in Upstate South Carolina
- Business Hotels in Upstate South Carolina
- Cheap Hotels in Upstate South Carolina
- Family Hotels in Upstate South Carolina
- Golf Hotels in Upstate South Carolina
- Historic Hotels in Upstate South Carolina
- Hotel Wedding Venues in Upstate South Carolina
- Hotel with a Concierge in Upstate South Carolina
- Hotels with Bars in Upstate South Carolina
- Hotels with Early Check-in in Upstate South Carolina
- Hotels with Free Parking in Upstate South Carolina
- Hotels with Hot Tubs in Upstate South Carolina
- Hotels with WiFi in Upstate South Carolina
- Hotels with a Pool in Upstate South Carolina
- Hotels with an Indoor Pool in Upstate South Carolina
- Hotels with smoking rooms in Upstate South Carolina
- Luxury Hotels in Upstate South Carolina
- Pet-friendly Hotels in Upstate South Carolina
- Resorts & Hotels with Spas in Upstate South Carolina
- Romantic Hotels in Upstate South Carolina
- Shopping Hotels in Upstate South Carolina
- Ski Hotels in Upstate South Carolina
More Accommodation Types in Upstate South Carolina
Explore more hotels
- ECHO Suites Extended Stay by Wyndham Spartanburg
- Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
- Drury Inn & Suites Greenville
- Embassy Suites by Hilton Greenville Downtown Riverplace
- Best Western Plus Clemson Hotel & Conference Center
- The Westin Poinsett Greenville
- DoubleTree by Hilton Greenville Woodruff Road
- Fairfield Inn by Marriott Greenville-Spartanburg Airport
- Quality Inn Seneca Clemson Area US-123
- Comfort Inn & Suites Clemson - University Area
- Spartanburg Marriott
- Comfort Suites At WestGate Mall
- The Shepherd Hotel Downtown Clemson
- Baymont by Wyndham Easley/Greenville
- Sleep Inn Spartanburg Southwest
- Comfort Inn & Suites Greer - Greenville
- Lakeside Lodge Clemson
- Best Western Plus Greenville South
- Holiday Inn Express Gaffney by IHG
- Inn @ Clemson




















