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Find hotels in Santa Lucia, Syracuse

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Dec 23 - Dec 24
Tomorrow
Dec 24 - Dec 25
This weekend
Dec 26 - Dec 28
Next weekend
Jan 2 - Jan 4

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Our top choices for Santa Lucia hotels

Terrace/patio
Caportigia Boutique Hotel

Caportigia Boutique Hotel

Caportigia Boutique Hotel
5.0 star property
Santa Lucia
9.4 out of 10, Exceptional, (257)
"Fine quality hotel with exceptional service. "
United States
Peter
The price is NT$4,300
NT$5,100 total
includes taxes & fees
Jan 5 - 2026/1/6
Caportigia Boutique Hotel
Terrace/patio
Piccolo Hotel Casa Mia

Piccolo Hotel Casa Mia

Piccolo Hotel Casa Mia
3.0 star property
Santa Lucia
8.6 out of 10, Excellent, (373)
"The staff is extremely nice and friendly and you feel welcome. "
Canada
Florentina
Piccolo Hotel Casa Mia
Aerial view
Grande Albergo Alfeo

Grande Albergo Alfeo

Grande Albergo Alfeo
4.0 star property
Santa Lucia
8.6 out of 10, Excellent, (651)
"The room was nice the location convenient. No view to speak of but centrally located"
Canada
Eric
Grande Albergo Alfeo
Coffee/tea maker, electric kettle
Nostos rooms & Apartments

Nostos rooms & Apartments

Nostos rooms & Apartments
3.0 star property
Santa Lucia
9.0 out of 10, Wonderful, (273)
"On a main thoroughfare close to Isola di Ortigia. Friendly management and helpful to me."
United States
John
The price is NT$2,150
NT$2,451 total
includes taxes & fees
Jan 7 - 2026/1/8
Nostos rooms & Apartments
Double Room | Premium bedding, desk, cribs/infant beds, rollaway beds
B&B Siracusa

B&B Siracusa

B&B Siracusa
Santa Lucia
9.0 out of 10, Wonderful, (59)
"Good location, very modern clean accommodation."
Canada
Malcolm
The price is NT$2,520
NT$2,873 total
includes taxes & fees
Dec 28 - Dec 29
B&B Siracusa
Exclusive Room | In-room safe, soundproofing, iron/ironing board, free WiFi
Isonzo Suites

Isonzo Suites

Isonzo Suites
Santa Lucia
8.4 out of 10, Very Good, (5)
"."
Italy
Gianluca
The price is NT$2,134
NT$3,533 total
includes taxes & fees
Jan 14 - 2026/1/15
Isonzo Suites
Triple Room, Balcony | Balcony
B&B Nike

B&B Nike

B&B Nike
Santa Lucia
8.8 out of 10, Excellent, (75)
"Clean, good location. "
United States
Salvatore
B&B Nike
View from room
Hotel Mediterraneo

Hotel Mediterraneo

Hotel Mediterraneo
3.0 star property
Santa Lucia
7.8 out of 10, Good, (122)
"Very friendly and helpful staff."
United States
David
Hotel Mediterraneo
Full-size fridge, oven, stovetop, cookware/dishes/utensils
Gymnasium

Gymnasium

Gymnasium
3.0 star property
Santa Lucia
8.8 out of 10, Excellent, (40)
"Nice kitchen area, centrally located."
United States
Richard
Gymnasium
Property entrance
Giuggiulena Villa

Giuggiulena Villa

Giuggiulena Villa
3.0 star property
Santa Lucia
10.0 out of 10, Exceptional, (126)
"Fantastic stay. Made to feel very welcome and what a lovely relaxing place to stay. Evening meal was exceptional. "
United States
Paul
The price is NT$6,894
NT$7,859 total
includes taxes & fees
Jan 7 - 2026/1/8
Giuggiulena Villa
View from room
Calafatari B&B

Calafatari B&B

Calafatari B&B
3.0 star property
Santa Lucia
10.0 out of 10, Exceptional, (11)
"We had a lovely stay. Anna was very welcoming. We had a lovely large clean room and a nice modern bathroom. She went all out for breakfast. "
United States
Carl and Lina
Calafatari B&B
Terrace/patio
Populus

Populus

Populus
1.0 star property
Santa Lucia
7.8 out of 10, Good, (74)
"Just stay somewhere else, plain and simple."
United States
Thomas
The price is NT$2,721
NT$3,103 total
includes taxes & fees
Jan 5 - 2026/1/6
Populus
Exterior
Hotel dei Coloniali

Hotel dei Coloniali

Hotel dei Coloniali
3.0 star property
Santa Lucia
7.4 out of 10, Good, (166)
"Convenient location for Syracuse town, but in a scruffy area and the whole property is looking tired. Breakfast was adequate. The owner was charming and happy to help."
United Kingdom
Rod
Hotel dei Coloniali
Exterior
AmaCasa Siracusa

AmaCasa Siracusa

AmaCasa Siracusa
Santa Lucia
10.0 out of 10, Exceptional, (1)
"Siamo stati molto bene, la struttura internamente è abbastanza ammodernata e l'accesso è stato"
Italy
Alessandro
The price is NT$3,024
NT$3,447 total
includes taxes & fees
Jan 5 - 2026/1/6
AmaCasa Siracusa
Suite, Balcony, Sea View | Minibar, in-room safe, desk, soundproofing
Lakkios

Lakkios

Lakkios
3.0 star property
Santa Lucia
9.0 out of 10, Wonderful, (63)
"Nice, central, clean, easy to park, quiet during the night, staff was welcoming, nice breakfast with view - excellent choice!"
Norway
Jon-Kåre
Lakkios
Triple Room, Housekeeping, City View | Desk, laptop workspace, free WiFi
Agorà

Agorà

Agorà
Santa Lucia
10.0 out of 10, Exceptional, (1)
"Carlo was great. He wanted to help in any way. The room was excellent except for Friday night music and traffic. You want to party it is near there. Would stay there again. Walkable to most places. Good restaurants near by."
United States
Bryce
The price is NT$2,313
NT$2,637 total
includes taxes & fees
Dec 24 - Dec 25
Agorà
Water view
Re Dionisio Luxury Suites

Re Dionisio Luxury Suites

Re Dionisio Luxury Suites
3.0 star property
Santa Lucia
8.8 out of 10, Excellent, (57)
"Spacious room, dated but comfortable."
United States
Kenneth
The price is NT$8,074
NT$9,251 total
includes taxes & fees
Dec 28 - Dec 29
Re Dionisio Luxury Suites
Suite | Soundproofing, free WiFi
Hotel Palazzo Cavalieri

Hotel Palazzo Cavalieri

Hotel Palazzo Cavalieri
4.0 star property
Santa Lucia
8.8 out of 10, Excellent, (39)
"The location of this hotel is ideal! Directly between the train station and Ortigia. Easy walking to many different restaurants. We very much enjoyed our short stay here and the daily activities hosted by the Hotel. My only iffy thing was the tiles in the bathroom (the shower specifically) seemed a bit older and maybe not as cleanly as it could be, but all in all the room was quite nice. "
Canada
Lindsay
The price is NT$3,627
NT$4,135 total
includes taxes & fees
Jan 3 - 2026/1/4
Hotel Palazzo Cavalieri
Egyptian cotton sheets, premium bedding, down comforters
Fortuna Guest House

Fortuna Guest House

Fortuna Guest House
1.0 star property
Santa Lucia
9.2 out of 10, Wonderful, (16)
"The owner was really nice and helpful! Really enjoyed our stay here."
Finland
Kirsi
The price is NT$3,643
NT$4,153 total
includes taxes & fees
Jan 6 - 2026/1/7
Fortuna Guest House
Superior Triple Room, Sea View | Memory foam beds, in-room safe, individually furnished, desk
Fortaleza Charme House

Fortaleza Charme House

Fortaleza Charme House
Santa Lucia
10.0 out of 10, Exceptional, (27)
"Great central location."
United States
Craig
The price is NT$5,307
NT$6,050 total
includes taxes & fees
Jan 5 - 2026/1/6
Fortaleza Charme House
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Santa Lucia

Find the best Santa Lucia areas and neighborhoods for the activities you enjoy most.
Temple of Apollo featuring a ruin and heritage elements

Ortigia

Travelers come to Ortigia for its seaside views, and you can see top attractions like Cathedral of Syracuse and Piazza del Duomo while you're in town.

Tiche

Gardens and restaurants are notable features of Tiche. You might consider a stop by Ionian Sea while you're exploring the neighborhood.

Neapolis

While visiting Neapolis, you might make a stop by sights like Roman Amphitheatre of Syracuse and Archaeological Park of Neapolis.

Acradina

You'll enjoy the churches and seaside views in Acradina. You might want to make time for a stop at Ionian Sea or Capuchin Quarry.

Grottasanta

Grottasanta is noteworthy for its historic sites, and you can make a stop at top attractions like Pista Ciclabile Siracusa and Ionian Sea.

Top Santa Lucia Hotel Reviews

Algila' Ortigia Charme Hotel

Algila' Ortigia Charme Hotel

10/10 Excellent
"Overall, an excellent hotel in a great location. Beautiful building, comfortable bed, wonderful breakfast in the morning. Really can’t complain about anything. "
Charlie 4-night trip
Posted 2 weeks ago
Algila' Ortigia Charme Hotel

Frequently asked questions

What is Santa Lucia like?
Santa Lucia is a neighborhood that people enjoy for its interesting historical sites. Are you looking for Santa Lucia travel tips? Be sure to check out Porto Piccolo and Ionian Sea while you're in the neighborhood.
Where is the best place to stay in Santa Lucia?
Based on Expedia customer reviews, Fortaleza Charme House is the highest ranked property in Santa Lucia. This inn offers a beach bar and free WiFi. Other top choices in the neighborhood include Giuggiulena Villa and Lakkios.
How many hotels can I expect to find in Santa Lucia?
Expedia has 292 hotels and other accommodations in Santa Lucia to choose from, making this an ideal home base for exploring the greater Syracuse area.
If I need to cancel my hotel reservation in Santa Lucia, will I receive a refund?
Yes, you'll find most hotel bookings are fully refundable provided that you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your check-in date. If you booked a non-refundable reservation, you might be able to cancel it and be given a refund within 24 hours of your booking. Add your dates and click on "Search", then use the filter option "fully refundable" to get the best options available in Santa Lucia.
Where can I learn more about changing or cancelling my trip to Santa Lucia?
For more details about changing or cancelling your trip to Santa Lucia, click here.
What are the top things to see and do in Santa Lucia?
Landmarks in Santa Lucia that you won't want to miss include Syracuse Forum Ruins and Santa Lucia Bridge. Porto Piccolo and Ionian Sea are some other stops to visit in the neighborhood. A few places to visit in the area around Santa Lucia include Piazza Santa Lucia, Santa Lucia al Sepolcro Basilica, and Madonna delle Lacrime. When you're sightseeing in Syracuse, Papyrus Museum and Museo Archeologico Regionale Paolo Orsi are also worth a stop.