A calm lake reflecting trees with autumn foliage, a clear sky, and a distant shoreline.

Find Luxury Hotels in St. Charles, MO

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
  • Be picky

    Search almost a million properties worldwide

Check availability on St. Charles Luxury Hotels

Tonight
Oct 11 - Oct 12
Tomorrow
Oct 12 - Oct 13
Next weekend
Oct 16 - Oct 18
In two weeks
Oct 23 - Oct 25

Our top choices for St. Charles luxury hotels

1. Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa
St. Charles
  • Indulge in lavish comfort at this St. Charles retreat featuring a full-service spa, seasonal pool, and 6 exceptional restaurants.
NT$5,718
NT$7,213 total
includes taxes & fees
Oct 12 - Oct 13
Ameristar Casino Resort and Spa

2. DoubleTree by Hilton Hotel St. Louis - Chesterfield

DoubleTree by Hilton Hotel St. Louis - Chesterfield
Chesterfield
  • Chesterfield hotel offers plush comforts with indoor tennis courts, dual pools, and premium bedding.
NT$4,424
NT$5,132 total
includes taxes & fees
Oct 30 - Oct 31
DoubleTree by Hilton Hotel St. Louis - Chesterfield

3. The Royal Sonesta Chase Park Plaza St. Louis

The Royal Sonesta Chase Park Plaza St. Louis
Central West End
  • Indulge in historic elegance at this St. Louis gem featuring 3 restaurants, a spectacular pool area, and luxurious rooms near Forest Park.
NT$5,140
NT$7,003 total
includes taxes & fees
Nov 1 - Nov 2
The Royal Sonesta Chase Park Plaza St. Louis

4. The Cheshire

The Cheshire
Richmond Heights
NT$4,738
NT$5,626 total
includes taxes & fees
Oct 18 - Oct 19
The Cheshire

5. Drury Plaza Hotel St. Louis Brentwood

Drury Plaza Hotel St. Louis Brentwood
Brentwood
NT$4,182
NT$4,966 total
includes taxes & fees
Nov 1 - Nov 2
Drury Plaza Hotel St. Louis Brentwood

6. The Ritz-Carlton, St. Louis

The Ritz-Carlton, St. Louis
Clayton
  • Ritz-Carlton elegance defines this St. Louis retreat with indulgent spa services and dining excellence.
NT$18,485
NT$21,579 total
includes taxes & fees
Nov 1 - Nov 2
The Ritz-Carlton, St. Louis

7. 21C Museum Hotel St Louis

21C Museum Hotel St Louis
Downtown West
  • Indulge in artistic luxury at this downtown St. Louis hotel with spa services and indoor pool.
NT$4,586
NT$5,522 total
includes taxes & fees
Nov 1 - Nov 2
21C Museum Hotel St Louis

8. The Westin St. Louis

The Westin St. Louis
Downtown St. Louis
  • Opulent downtown retreat with pillowtop beds, soaking tubs, and Italian dining moments from Busch Stadium.
NT$4,186
NT$4,895 total
includes taxes & fees
Oct 18 - Oct 19
The Westin St. Louis

9. Four Seasons Hotel St Louis

Four Seasons Hotel St Louis
Downtown St. Louis
  • Lavish riverside luxury awaits at the Four Seasons St. Louis with spa indulgences and poolside bliss.
NT$11,972
NT$13,999 total
includes taxes & fees
Oct 12 - Oct 13
Four Seasons Hotel St Louis

10. The Inn at Elijah McLeans

The Inn at Elijah McLeans
Washington
NT$4,310
NT$4,907 total
includes taxes & fees
Oct 12 - Oct 13
The Inn at Elijah McLeans
View all properties

Top St. Charles Hotel Reviews

Pear Tree Inn St. Louis Near Union Station

Pear Tree Inn St. Louis Near Union Station

8/10 Good
"friendly staff, great for kids"
Samantha 2-night trip
Posted less than an hour ago
Pear Tree Inn St. Louis Near Union Station
Forest Park Hotel by MDR

Forest Park Hotel by MDR

8/10 Good
"We were 2 people staying here, but only 1 coffee and 1 tea with the coffee maker. Combined with the lack of kleenex (have to use toilet paper), it does make cost cutting measures a bit obvious (assuming that is why)? Also, last night coming back from dinner, the hallway by the elevator on the forst floor smelled like urine! Otherwise, a convenient location (if a bit noisy due to the train & highway), and the room is generally nice, though the amenities seemed skimpy. Certain areas could use some new paint, and only one of the 2 elevators appeared to be working (& it made some disconcerting noises)... but a decent trip. Fairly no frills and less expensive."
Robyn and Jon 1-night trip
Posted less than an hour ago
Forest Park Hotel by MDR
Drury Plaza Hotel St. Louis Union Station

Drury Plaza Hotel St. Louis Union Station

10/10 Excellent
"Bed very comfortable, clean room, staff friendly and helpful. Good location. Food in evening was amazing. Breakfast buffet was good, about like other hotels as far as choices, nicely setup tho."
Linda 1-night trip
Posted 1 hour ago
Drury Plaza Hotel St. Louis Union Station
Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

10/10 Excellent
"Good breakfast, nice service, nice room! Really good shower too, let you set the temperature"
Sarah 2-night trip
Posted 2 hours ago
Clayton Plaza Hotel & Extended Stay
Drury Plaza Hotel St. Louis at the Arch

Drury Plaza Hotel St. Louis at the Arch

10/10 Excellent
"Clean room good breakfast"
amber 1-night trip
Posted 3 hours ago
Drury Plaza Hotel St. Louis at the Arch
Embassy Suites by Hilton St. Louis St. Charles

Embassy Suites by Hilton St. Louis St. Charles

10/10 Excellent
"Great place to stay"
Elyse 3-night trip
Posted 21 hours ago
Embassy Suites by Hilton St. Louis St. Charles
Country Inn & Suites by Radisson, St. Charles Historic District

Country Inn & Suites by Radisson, St. Charles Historic District

10/10 Excellent
"All good and lovely staff"
Heidi 4-night trip
Posted 1 day ago
Country Inn & Suites by Radisson, St. Charles Historic District
Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

8/10 Good
"Wonderful stay for a small bachelorette party. Had a wonderful time!"
Kara 1-night trip
Posted 1 day ago
Ameristar Casino Resort and Spa

Frequently asked questions

Are you looking for a luxury hotel for your stay in St. Charles?
During your visit, you might want to enjoy the casinos and shopping which St. Charles is known for.
What's the best luxury hotel in St. Charles?
Ameristar Casino Resort and Spa is a luxury hotel with 6 restaurants and 2 bars, and it's a popular choice for Expedia travelers looking for an elegant place to stay.
When can I expect good weather in St. Charles?
Planning for the weather is an important factor for making your trip to St. Charles a success, especially when you're splurging. The hottest months are usually July and August with an average temp of 75°F, while the coldest months are January and February with an average of 37°F. Average annual precipitation for St. Charles is 46 inches.
What's there to see and do in St. Charles?
When you're in St. Charles, enjoy exploring the sights and attractions here including Historic Main Street, Katy Trail, and Lewis & Clark Boathouse and Nature Center. If you have a little extra time during your trip, you might want to make a stop at St Charles Convention Center and Ameristar Casino St. Charles.

Explore a world of travel with Expedia