Find Casinos in St. Charles, MO

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Our top choices for St. Charles hotels with a casino

Super 8 by Wyndham St Charles

Super 8 by Wyndham St Charles
2.0 star property
St. Charles
8.0 out of 10, Very Good, (1001)
"I'd stay at this place again. "
United States
Suzanne
The price is NT$2,378
NT$2,733 total
includes taxes & fees
Jan 11 - 2026/1/12
Super 8 by Wyndham St Charles

Comfort Suites St Charles - St Louis

Comfort Suites St Charles - St Louis
2.5 star property
St. Charles
8.4 out of 10, Very Good, (1000)
"Nice staff at reception. "
United States
Denise
The price is NT$2,472
NT$2,841 total
includes taxes & fees
Jan 11 - 2026/1/12
Comfort Suites St Charles - St Louis

Country Inn & Suites by Radisson, St. Charles Historic District

Country Inn & Suites by Radisson, St. Charles Historic District
2.5 star property
St. Charles Historic District
9.4 out of 10, Exceptional, (1003)
"Everything was great!"
United States
Rita
The price is NT$3,532
NT$4,060 total
includes taxes & fees
Jan 25 - 2026/1/26
Country Inn & Suites by Radisson, St. Charles Historic District

Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa
4.5 star property
St. Charles
8.4 out of 10, Very Good, (1006)
"Clean room, wonderful helpful pleasant staff, amenities, everything was great love staying here!"
United States
Robyn
The price is NT$5,317
NT$6,736 total
includes taxes & fees
Dec 29 - Dec 30
Ameristar Casino Resort and Spa

Hampton Inn & Suites St. Charles Old Town Area

Hampton Inn & Suites St. Charles Old Town Area
2.5 star property
St. Charles
9.2 out of 10, Wonderful, (637)
"Huge room. Great breakfast. "
United States
David
The price is NT$3,405
NT$4,104 total
includes taxes & fees
Jan 25 - 2026/1/26
Hampton Inn & Suites St. Charles Old Town Area

Embassy Suites by Hilton St. Louis St. Charles

Embassy Suites by Hilton St. Louis St. Charles
3.5 star property
St. Charles
8.8 out of 10, Excellent, (1007)
"Breakfast was excellent along with clean comfortable beds. "
United States
Scott
The price is NT$3,841
NT$4,414 total
includes taxes & fees
Jan 4 - 2026/1/5
Embassy Suites by Hilton St. Louis St. Charles
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find out more about St. Charles

Discover top St. Charles attractions

St. Charles, Missouri, offers a thrilling getaway for casino enthusiasts, particularly with the nearby Ameristar Casino Resort Spa, which features a sprawling gaming floor with over 1,500 slot machines and a variety of table games. After an exciting night at the casino, families can explore the historic Main Street, where charming boutiques and restaurants line the streets, making it perfect for leisurely strolls. For those interested in live entertainment, the River City Casino provides a vibrant atmosphere with regular shows and events that cater to all tastes. Adventure seekers can also enjoy a boat ride on the Missouri River or visit the nearby Katy Trail for hiking and biking, adding a dose of outdoor fun to your trip. When it comes to accommodations, staying in the vicinity of the casino resorts ensures you can easily access gaming and entertainment while enjoying luxurious amenities, such as spa services and fine dining. With attentive guest service and family-friendly options, your visit will be both exciting and relaxing.

Top St. Charles Hotel Reviews

Frequently asked questions

Searching for casino hotels in St. Charles?
Hoping to win big in St. Charles? Lucky for you, you'll find Ameristar Casino St. Charles here, not to mention much more to see and do. Tourists speak highly of the historic landmarks, family-friendly activities, and local cuisine.
What's the best place to stay for casino gaming in St. Charles?
Ameristar Casino Resort and Spa is a top hotel featuring a casino and a full-service spa.
How many hotels that are good for gaming should I expect to find in St. Charles?
You won't need a stroke of luck to find something that suits with one of Expedia's 160 casino hotels in St. Charles.
When should I take my casino trip to St. Charles?
You might spend a lot of your vacation inside, but if you're planning to venture beyond the casino, taking a look at local weather data can help you. The hottest months are usually July and August with an average temp of 75°F, while the coldest months are January and February with an average of 37°F. Average annual precipitation for St. Charles is 46 inches.
What is there to do in St. Charles?
Lucky gamers can head to Westport Plaza, Mid Rivers Mall, and St. Louis Premium Outlets to spend their winnings. St. Charles is known for its historic sites and live music, and you can check out cultural spots such as Missouri Artists on Main, Hollywood Casino Amphitheatre, and The Factory. In addition, you might want to visit Historic Main Street and First Missouri State Capitol Historic Site.
What are my transportation options for my casino getaway to St. Charles?
Getting around St. Charles is easier with these transportation options: You can fly into the nearest airport, which is St. Louis Lambert Intl. Airport (STL), located 7.7 mi (12.5 km) from the city center. If you'd like to venture out around the area, you may want a rental car for your journey.

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