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Santa Cruz Vacation Rentals

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Check prices for these dates

In two weeks
Aug 7 - Aug 9
In two months
Sep 18 - Sep 20
In three months
Oct 16 - Oct 18
In four months
Nov 13 - Nov 15

Our top choices for Santa Cruz vacation rentals

Living area

Skyline Ecoliving

Skyline Ecoliving
3.0 star property
El Rosario
9.2 out of 10, Wonderful, (42 reviews)
"Increíble view.. comfortable clean!! "
United States
Hector
The price is NT$1,891
NT$2,372 total
Jul 24 - Jul 25
Skyline Ecoliving
Restaurant

Edificio Helena

Edificio Helena
3.0 star property
Medellín
8.8 out of 10, Excellent, (64 reviews)
"Awesome breakfast, great location. Great host"
United States
James
The price is NT$1,273
NT$1,273 total
Aug 20 - Aug 21
Edificio Helena
Reception

Metropolitan Living by HOUSY

Metropolitan Living by HOUSY
4.0 star property
San Diego
9.2 out of 10, Wonderful, (71 reviews)
"Staff was very polite, location was perfect… very close to amazing tourism spots! "
United States
Patricia
The price is NT$1,506
NT$2,216 total
Jul 23 - Jul 24
Metropolitan Living by HOUSY
Coffee shop

B 48 Living by B Rent

B 48 Living by B Rent
4.0 star property
Laureles - Estadio
9.6 out of 10, Exceptional, (20 reviews)
"I love the people & I love the area. One of the best place to stay in Medellin. "
United States
Lusene
The price is NT$1,874
NT$1,874 total
Jul 24 - Jul 25
B 48 Living by B Rent
Comfort Double Room | Premium bedding, down comforters, minibar, WiFi (free)

Hotel Moore 45

Hotel Moore 45
4.0 star property
Buenos Aires
8.8 out of 10, Excellent, (3 reviews)
"I like the service and it’s really comfortable. And the people in their recession. Bety. Help. Take you guys. I Enjoy the State. I’m planning to Come Back. How old is go back to the hotel again!"
United States
Welinton
The price is NT$1,049
NT$1,049 total
Jul 23 - Jul 24
Hotel Moore 45
Restaurant

Hotel Distrito 70 Living

Hotel Distrito 70 Living
3.0 star property
Laureles - Estadio
10.0 out of 10, Exceptional, (2 reviews)
"great location. cooked to order eggs n fruit for breakfast w juice n coffee...clean room with a/c...nothing to complain about,,,"
United States
howard
The price is NT$1,487
NT$1,487 total
Aug 11 - Aug 12
Hotel Distrito 70 Living
Comfort Apartment | Living area | Flat-screen TV

Loft 43

Loft 43
3.0 star property
Laureles
8.8 out of 10, Excellent, (30 reviews)
"Fabulous room with floor to ceiling windows, comfortable bed, hot water in the shower and a strong wifi connection. Close to Estadio metro station and La Setenta for food and nightlife. Staff were friendly and check-in was fast. Light sleepers might find the neighborhood a bit loud. There are many local restaurants along Calle 43 (just head away from La 70) for lunch and dinner."
United States
Daniel
The price is NT$1,872
NT$1,872 total
Jul 23 - Jul 24
Loft 43
Outdoor pool

Casa Museo by HOUSY

Casa Museo by HOUSY
3.5 star property
Laureles
8.4 out of 10, Very Good, (5 reviews)
"I highly recommend staying here. It’s centrally located, comfortable, clean, and the service is excellent."
United States
Carlos
The price is NT$1,468
NT$2,375 total
Jul 29 - Jul 30
Casa Museo by HOUSY
WiFi (free)

hotel civitas medellin

hotel civitas medellin
2.5 star property
La Candelaria
8.8 out of 10, Excellent, (3 reviews)
"Hotel in a good location, comfortable and has a great staff."
United States
Valencia
The price is NT$859
NT$859 total
Jul 23 - Jul 24
hotel civitas medellin
Outdoor spa tub

Quadrato Studios

Quadrato Studios
3.0 star property
Laureles
9.4 out of 10, Exceptional, (107 reviews)
"Beautiful hotel great location great breakfast"
United States
gary
The price is NT$1,361
NT$1,361 total
Aug 12 - Aug 13
Quadrato Studios
Staircase

zenia

zenia
3.0 star property
Laureles
9.4 out of 10, Exceptional, (55 reviews)
"Wonderful place. Brilliant staff."
United States
Moriah
The price is NT$974
NT$974 total
Jul 23 - Jul 24
zenia
Deluxe Apartment, 1 Queen Bed with Sofa bed, Non Smoking, Kitchen | 1 bedroom, premium bedding, down comforters, in-room safe

Portal del Rodeo ApartaHotel - Arkadia Mall

Portal del Rodeo ApartaHotel - Arkadia Mall
3.5 star property
Medellín
9.0 out of 10, Wonderful, (287 reviews)
"Excellent place to stay with family and friends!"
Canada
Jose
The price is NT$2,530
NT$2,530 total
Aug 10 - Aug 11
Portal del Rodeo ApartaHotel - Arkadia Mall
Loft, 1 Double Bed | Egyptian cotton sheets, premium bedding, down comforters

Factory Lofts

Factory Lofts
4.0 star property
Laureles - Estadio
9.8 out of 10, Exceptional, (132 reviews)
"Amazing experience. The staff was extremely helpful and some spoke good english."
United States
Thomas
The price is NT$2,830
NT$3,734 total
Jul 27 - Jul 28
Factory Lofts
Lobby

Haven, A Design Hotel

Haven, A Design Hotel
4.0 star property
El Poblado
8.8 out of 10, Excellent, (706 reviews)
"The reception staff were great hosts, the room was as advertised. A nice hotel and good location"
United States
Neil
The price is NT$3,329
NT$3,329 total
Jul 23 - Jul 24
Haven, A Design Hotel
Free daily full breakfast

Laureles Guest House - LGH Hotel

Laureles Guest House - LGH Hotel
3.5 star property
Laureles
9.2 out of 10, Wonderful, (100 reviews)
"Excellent breakfast, good location "
United States
dickie
The price is NT$1,444
NT$1,444 total
Jul 28 - Jul 29
Laureles Guest House - LGH Hotel
Front of property

Nomadic Boutique Living and Experience Center

Nomadic Boutique Living and Experience Center
4.0 star property
El Poblado
9.8 out of 10, Exceptional, (17 reviews)
"Good property and the area looks safe."
Canada
Josue
The price is NT$2,045
NT$2,293 total
Aug 16 - Aug 17
Nomadic Boutique Living and Experience Center
Exterior

Edificio Atalanta

Edificio Atalanta
3.5 star property
Laureles
9.0 out of 10, Wonderful, (14 reviews)
"Everything was nice and clean and the staff was super friendly. Will book again without hesitation. Thank you for the service."
United States
Caroline
The price is NT$1,524
NT$1,524 total
Aug 17 - Aug 18
Edificio Atalanta
Front of property

Amaranto Suites

Amaranto Suites
3.0 star property
Laureles - Estadio
9.8 out of 10, Exceptional, (6 reviews)
"Perfect"
United States
Alexander
The price is NT$1,424
NT$1,424 total
Aug 20 - Aug 21
Amaranto Suites
Full-size fridge, microwave, oven, stovetop

Luxury Suites Prana By Cadissa

Luxury Suites Prana By Cadissa
5.0 star property
Laureles - Estadio
9.4 out of 10, Exceptional, (49 reviews)
"It was very easy to check in and out. The apartment had everything we needed to be comfortable. The location was great. We were able to walk around and felt very safe. I highly recommend it if you are looking for an affordable place with good customer service and cleanliness."
United States
Mahely
The price is NT$3,072
NT$4,428 total
Aug 18 - Aug 19
Luxury Suites Prana By Cadissa
Lobby sitting area

HOUSY Laureles

HOUSY Laureles
4.0 star property
Laureles
9.2 out of 10, Wonderful, (100 reviews)
"The staff was very friendly—Juliana, in particular, was very kind. There is a security company with a 24/7 guard in the building across the street."
United States
Moraima
The price is NT$1,674
NT$2,710 total
Aug 10 - Aug 11
HOUSY Laureles
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Santa Cruz Hotel Reviews

V Grand Hotel, a member of Radisson Individuals

V Grand Hotel, a member of Radisson Individuals

10/10 Excellent
"We had an excellent experience at this hotel. The staff was always friendly and helpful. The location was excellent. This hotel is in the center of Poblado and there were great restaurants at walking distance from the hotel. The room was sparkling clean. It comes with your standard liquid shower gel, shampoo, and conditioner. They smell really good. You get two small bottles of water and a couple of coffee pods that get replenished every day. Anything else you take from the mini bar is an extra charge. The included breakfast is delicious. There are your typical sliced breads, mini croissants, arepas, pancakes, waffles, etc. They also include fruits, yogurt, and cereal. There is a section for scrambled eggs, omelettes, soups, rice, vegetables and meat (sometimes.)"
Fernanda 7-night trip
Posted less than an hour ago
V Grand Hotel, a member of Radisson Individuals

Find out more about Santa Cruz

Search for holiday rentals in Santa Cruz on Expedia! You can easily find your home rentals, villas, holiday apartments in Santa Cruz using one of the methods below:

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Look no further and take a look at our great range of rental properties in Santa Cruz!

Frequently asked questions

Can I find a vacation rental in Santa Cruz?

Yes, we offer vacation rentals close to popular attractions in Santa Cruz, or you can choose a more secluded option if you want a relaxing place to stay.

What's the top vacation rental in Santa Cruz?

Luxury Home In Las Lomas: You might want to consider this vacation home rental near Santa Cruz, which is equipped with an outdoor pool, air-conditioning, and free WiFi to help you feel comfortable during your stay. It has 6 bedrooms as well as a kitchen with a full-sized fridge, a microwave, and a coffee maker, so you can cook with friends or family.

What’s there to see and do in Santa Cruz?

While exploring the area, visit family-friendly sights like Pueblito Paisa, or get outside and enjoy nature at Medellin Botanical Garden. In the larger area, you’ll find University of Antioquia and Arvi Park.

What’s a vacation rental in Santa Cruz like?

Vacation rentals are private properties where you can stay for a long or short time in Santa Cruz. Vacation rentals feature extras such as hot tubs, fire pits, and patios so you'll feel just like you're at home. If you're concerned about cleanliness, a vacation rental can offer a sense of safety away from public hotel elevators and lobbies bustling with people while still allowing you the excitement and enjoyment of travel. You'll also have more space in a vacation rental than in a standard hotel, which is another reason why a vacation rental is an attractive option for families.