Find hotels in Sanctuary, Sanibel

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Next weekend
In two weeks

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Sanctuary hotels

Lani Kai Beachfront Resort

Lani Kai Beachfront Resort
3.5 star property
21.8 km from Sanctuary
9.0 out of 10, Wonderful, (1,515 reviews)
"I really enjoyed my vacation here. I love the beachfront rooms."
United States
Christina
The price is NT$3,947
NT$5,105 total
includes taxes & fees
May 27 - May 28
Lani Kai Beachfront Resort

Pointe Estero Beach Resort

Pointe Estero Beach Resort
2.0 star property
27.3 km from Sanctuary
9.2 out of 10, Wonderful, (1,000 reviews)
"Love this place!!"
United States
Teneille
The price is NT$5,107
NT$15,942 total
includes taxes & fees
May 28 - May 29
Pointe Estero Beach Resort

The Palmetto Inn

The Palmetto Inn
3.0 star property
31.2 km from Sanctuary
8.2 out of 10, Very Good, (118 reviews)
"Wonderful location in the center of Boca Grande. Easy walk to beachside. "
United States
Maria
The price is NT$4,575
NT$5,102 total
includes taxes & fees
May 25 - May 26
The Palmetto Inn

The Bay Inn at Lani Kai

The Bay Inn at Lani Kai
3.0 star property
21.8 km from Sanctuary
7.6 out of 10, Good, (415 reviews)
"Great stay "
United States
Ashley Q.
The price is NT$3,403
NT$4,498 total
includes taxes & fees
May 31 - Jun 1
The Bay Inn at Lani Kai

The Anchor Inn

The Anchor Inn
2.0 star property
Mid Island, 12.8 km from Sanctuary
9.8 out of 10, Exceptional, (39 reviews)
"We had a great time and would definitely stay there again!"
United States
William Edward
The price is NT$5,697
NT$6,825 total
includes taxes & fees
Jun 10 - Jun 11
The Anchor Inn

Latitude 26 Waterfront Boutique Resort - Fort Myers Beach

Latitude 26 Waterfront Boutique Resort - Fort Myers Beach
2.5 star property
21.5 km from Sanctuary
8.8 out of 10, Excellent, (1,005 reviews)
"Amazing place to stay! "
United States
Kristen
The price is NT$3,470
NT$3,869 total
includes taxes & fees
May 31 - Jun 1
Latitude 26 Waterfront Boutique Resort - Fort Myers Beach

Heated Pool, 3 Mi to Dtwn: Cape Coral Escape!

Heated Pool, 3 Mi to Dtwn: Cape Coral Escape!
3.0 star property
20.2 km from Sanctuary
10.0 out of 10, Exceptional, (1 review)
"This place was wonderful! The host is quick to respond to any questions. Cleanliness excellent. The kitchen has anything and everything you could possibly need. We would highly recommend It. Also is a convenient location to the beaches and downtown Cape Coral. We lived in Fort Myers and Cape Coral before hurricane Ian so we were familiar with the area. It’s also located in a very nice neighborhood. Thankyou for a great stay🍊☀️"
United States
Michael
The price is NT$2,935
NT$11,457 total
includes taxes & fees
Jun 13 - Jun 14
Heated Pool, 3 Mi to Dtwn: Cape Coral Escape!

Pink Shell Beach Resort and Marina

Pink Shell Beach Resort and Marina
4.0 star property
20.4 km from Sanctuary
9.4 out of 10, Exceptional, (1,371 reviews)
"Great stay!"
United States
John
The price is NT$11,814
NT$15,248 total
includes taxes & fees
Jun 18 - Jun 19
Pink Shell Beach Resort and Marina

Latitude 26 Waterfront Resort & Marina

Latitude 26 Waterfront Resort & Marina
3.0 star property
22 km from Sanctuary
8.6 out of 10, Excellent, (1,002 reviews)
"Nice and clean, friendly staff"
United States
Samuel
The price is NT$3,089
NT$3,444 total
includes taxes & fees
Jun 1 - Jun 2
Latitude 26 Waterfront Resort & Marina

Flamingo Inn

Flamingo Inn
3.0 star property
26.9 km from Sanctuary
7.8 out of 10, Good, (1,004 reviews)
"Very clean and a short walk to the ocean. The property manager accommodated everything we needed and was friendly. Definitely would recommend Flamingo Inn to everyone!"
United States
Cary
The price is NT$3,487
NT$6,032 total
includes taxes & fees
May 28 - May 29
Flamingo Inn

Shalimar Beach Resort

Shalimar Beach Resort
2.0 star property
West End, 10.3 km from Sanctuary
9.8 out of 10, Exceptional, (54 reviews)
"Lovely place to stay. Clean, quiet and right in the beach."
United States
Laura Elizabeth
The price is NT$11,012
NT$12,279 total
includes taxes & fees
Jun 1 - Jun 2
Shalimar Beach Resort

Best Western Plus Beach Resort

Best Western Plus Beach Resort
2.5 star property
20.9 km from Sanctuary
9.4 out of 10, Exceptional, (1,001 reviews)
"Great hotel"
United States
Carol J
The price is NT$7,934
NT$8,846 total
includes taxes & fees
Jun 7 - Jun 8
Best Western Plus Beach Resort

Sanibel Island Beach Resort

Sanibel Island Beach Resort
3.0 star property
Mid Island, 13.1 km from Sanctuary
9.2 out of 10, Wonderful, (1,918 reviews)
"This is the perfect place for a relaxing getaway!"
United States
Denise
The price is NT$7,857
NT$9,549 total
includes taxes & fees
May 31 - Jun 1
Sanibel Island Beach Resort

Tropical Mango Grove Stay Whiskey Creek Area

Tropical Mango Grove Stay Whiskey Creek Area
2.0 star property
28.2 km from Sanctuary
The price is NT$3,950
NT$10,217 total
includes taxes & fees
Jun 23 - Jun 24
Tropical Mango Grove Stay Whiskey Creek Area

Residence Inn by Marriott Fort Myers Sanibel

Residence Inn by Marriott Fort Myers Sanibel
3.0 star property
19.3 km from Sanctuary
8.8 out of 10, Excellent, (1,003 reviews)
"Wonderful location and accommodations!"
United States
Karen
The price is NT$3,250
NT$3,624 total
includes taxes & fees
May 27 - May 28
Residence Inn by Marriott Fort Myers Sanibel

Matlacha Tiny Village

Matlacha Tiny Village
3.0 star property
18.8 km from Sanctuary
8.8 out of 10, Excellent, (288 reviews)
"Quite and relaxing 👍"
United States
Andres
The price is NT$3,199
NT$8,300 total
includes taxes & fees
May 25 - May 26
Matlacha Tiny Village

Golf Getaway: Cape Coral Condo 1 Mi to River!

Golf Getaway: Cape Coral Condo 1 Mi to River!
3.0 star property
29.2 km from Sanctuary
The price is NT$1,735
NT$10,335 total
includes taxes & fees
May 31 - Jun 1
Golf Getaway: Cape Coral Condo 1 Mi to River!

La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway
3.0 star property
19.9 km from Sanctuary
8.2 out of 10, Very Good, (1,164 reviews)
"Nice location, close to the Sanibel Causeway Clean and helpful staff"
United States
Forrest
The price is NT$2,752
NT$3,068 total
includes taxes & fees
Jun 16 - Jun 17
La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG
2.5 star property
23.1 km from Sanctuary
9.2 out of 10, Wonderful, (1,002 reviews)
"Clean and close to Sanibel and Fort Myers beach."
United States
Stacey
The price is NT$2,935
NT$3,272 total
includes taxes & fees
May 27 - May 28
Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

The Lighthouse Resort Inn & Suites

The Lighthouse Resort Inn & Suites
3.0 star property
21.5 km from Sanctuary
8.6 out of 10, Excellent, (1,664 reviews)
"Perfect hotel and perfect location. "
United States
Niccole
The price is NT$3,363
NT$4,381 total
includes taxes & fees
May 27 - May 28
The Lighthouse Resort Inn & Suites
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Sanctuary

Find the best Sanctuary areas and neighborhoods for the activities you enjoy most.

Mid Island

While visiting Mid Island, you might make a stop by sights like Periwinkle Way and Sanibel Island Southern Beach.

West End

While visiting West End, you might make a stop by sights like J. N. Ding Darling National Wildlife Refuge and Bowman's Beach.

East End

While visiting East End, you might make a stop by sights like Sanibel Island Northern Beach and Sanibel Island Lighthouse.

Beachview Country Club Estates

If you're spending some time in Beachview Country Club Estates, Periwinkle Way and Sanibel Island Golf Club are top sights worth seeing.

Gulf Shores

While there might not be top attractions in Gulf Shores, you can explore the larger area and discover places like Bowman's Beach and J. N. Ding Darling National Wildlife Refuge.

Top Sanctuary Hotel Reviews

Frequently asked questions

What is Sanctuary like?
Travelers are sure to enjoy a stay in Sanibel's Sanctuary neighborhood. Consider a visit to J. N. Ding Darling National Wildlife Refuge as part of your Sanctuary travel plans.
How many hotels are there in the Sanctuary area?
With 10 Expedia hotels and other accommodations in Sanctuary to choose from, this is a good starting point for exploring the greater Sanibel area.
If I need to cancel my hotel reservation in Sanctuary, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable as long as you cancel before the hotel's cancellation deadline, which often is within 24-48 hours of your check-in date. If your reservation is non-refundable, it might still be possible to cancel it and get a refund within a 24-hour period of booking. Enter your dates, click on "Search", then you can use the "fully refundable" filter to review top deals in Sanctuary.
Where can I learn more about changing or cancelling my trip to Sanctuary?
For more information about updating your trip to Sanctuary or cancelling it, click here.
What is there to do around this Sanibel neighborhood?
J. N. Ding Darling National Wildlife Refuge is an attraction you might want to check out while you're in Sanctuary. Castaways Marina and Blind Pass Beach are also worth a visit when you're out sightseeing in Sanibel.

Explore a world of travel with Expedia