Photo by Anthony Hilario
Find Business Hotels in San Luis Obispo Wine Country, CA
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Check availability on San Luis Obispo Wine Country Business Hotels
Our top choices for San Luis Obispo Wine Country business-friendly hotels
8.8 out of 10, Excellent, (1263)
"I loved it definitely going back for our next trip "
Jasmin
The price is NT$3,594
NT$4,087 total
includes taxes & fees
Jan 4 - 2026/1/5
9.4 out of 10, Exceptional, (1302)
"Value for money, location, and two room configuration is excellent"
Karen
The price is NT$3,803
NT$4,955 total
includes taxes & fees
Jan 4 - 2026/1/5
9.2 out of 10, Wonderful, (1327)
"Great place."
Caeli
The price is NT$4,693
NT$6,399 total
includes taxes & fees
Jan 18 - 2026/1/19
La Quinta Inn & Suites by Wyndham San Luis Obispo Downtown
La Quinta Inn & Suites by Wyndham San Luis Obispo DowntownSan Luis Obispo
9.0 out of 10, Wonderful, (1809)
"Clean rooms and very nice staff"
Ana
The price is NT$3,653
NT$4,153 total
includes taxes & fees
Jan 15 - 2026/1/16
9.0 out of 10, Wonderful, (1573)
"Beautiful hotel and a wonderful staff."
Nadia
8.4 out of 10, Very Good, (1185)
"Clean and friendly staff "
Carlos
The price is NT$1,865
NT$2,494 total
includes taxes & fees
Dec 29 - Dec 30
The Wayfarer San Luis Obispo, Tapestry Collection by Hilton
The Wayfarer San Luis Obispo, Tapestry Collection by HiltonSan Luis Obispo
9.0 out of 10, Wonderful, (1000)
"Great location and friendly staff."
Lisa
The price is NT$3,711
NT$4,368 total
includes taxes & fees
Dec 30 - Dec 31
9.6 out of 10, Exceptional, (1000)
"Very nice hotel. Great for and rest and relaxation kind of vacation"
Princess
The price is NT$6,500
NT$7,312 total
includes taxes & fees
Dec 19 - Dec 20
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top San Luis Obispo Wine Country Hotel Reviews
Madonna Inn
10/10 Excellent
Frequently asked questions
Explore a world of travel with Expedia
- Pet-Friendly Hotels in Pismo Beach
- Beach Hotels in Pismo Beach
- Hotel Wedding Venues Hotels in Pismo Beach
- Hotels near Fremont Theater
- Casino Hotels in Pismo Beach
- 4 Star Hotels in San Luis Obispo
- Green Hotels in San Luis Obispo
- Luxury Hotels in San Luis Obispo
- Luxury Hotels in Avila Beach
- Winery Hotels in San Luis Obispo
- Hotels near Bob Jones City to Sea Bike Trail
- Hotels near Mission San Luis Obispo de Tolosa
- Best Western Hotels in San Luis Obispo
- Cheap Hotels in Pismo Beach
- Hotels with Hot Tubs in Avila Beach
- Shopping Hotels in Avila Beach
- Avila Beach Hotels
- Beach Hotels in Avila Beach
- Boutique Hotels in San Luis Obispo
- Hotels with Bars in Shell Beach
- Resorts & Hotels with Spas in San Luis Obispo
- Family Hotels in San Luis Obispo
- 5 Star Hotels in San Luis Obispo
- Resorts & Hotels with Spas in Los Osos
- Gay friendly Hotels in San Luis Obispo
- Hotels near San Luis Obispo County Regional
- Gay friendly Hotels in Pismo Beach
- Boutique Hotels in Pismo Beach
- Pacifica Hotels in San Luis Obispo
- Hotels with a Pool in San Luis Obispo
- Guest Houses in San Luis Obispo County
- Pet-Friendly Hotels in MoJo
- Resorts & Hotels with Spas in Shell Beach
- Luxury Hotels in Pismo Beach
- Cheap Hotels in San Luis Obispo
- Winery Hotels in Pismo Beach
- Family Hotels in Pismo Beach
- Hotels near French Hospital Medical Center
- Beach Hotels in Downtown San Luis Obispo
- Pet-Friendly Hotels in Avila Beach
- Hotels near Avila Beach Golf Resort
- Hotels with Bars in Arroyo Grande
- Shell Beach Hotels
- Flights from Zacatecas (ZCL) to San Luis Obispo (SBP)
- Flights from Kalispell (FCA) to San Luis Obispo (SBP)
- Flights from Cozumel (CZM) to San Luis Obispo (SBP)
- Flights from Lubbock (LBB) to San Luis Obispo (SBP)
- Flights from St. John's (YYT) to San Luis Obispo (SBP)
- Flights from Florence (FLR) to San Luis Obispo (SBP)
- Flights from Guangzhou (CAN) to San Luis Obispo (SBP)
- Flights from Montgomery (MGM) to San Luis Obispo (SBP)
- Flights from Naples (NAP) to San Luis Obispo (SBP)
- Flights from Charlotte (CLT) to San Luis Obispo (SBP)
- Flights from Billund (BLL) to San Luis Obispo (SBP)
- Flights from Curitiba (CWB) to San Luis Obispo (SBP)
- Flights from Santo Domingo (SDQ) to San Luis Obispo (SBP)
- Flights from Kearney (EAR) to San Luis Obispo (SBP)
- Flights from Ashland (ASX) to San Luis Obispo (SBP)
- Flights from San Francisco (SFO) to San Luis Obispo (SBP)
- Flights from Merced (MCE) to San Luis Obispo (SBP)
- Flights from Indianapolis (IND) to San Luis Obispo (SBP)
- Flights from Vernal (VEL) to San Luis Obispo (SBP)
- Flights from Key West (EYW) to San Luis Obispo (SBP)
- Flights from Fort Wayne (FWA) to San Luis Obispo (SBP)
- Flights from Harrisburg (MDT) to San Luis Obispo (SBP)
- Flights from Flagstaff (FLG) to San Luis Obispo (SBP)
- Flights from Vienna (VIE) to San Luis Obispo (SBP)
- Flights from Nice (NCE) to San Luis Obispo (SBP)
- Flights from London (LGW) to San Luis Obispo (SBP)
- Flights from Auburn (LEW) to San Luis Obispo (SBP)
- Flights from Springfield (SGF) to San Luis Obispo (SBP)
- Flights from Sochi (AER) to San Luis Obispo (SBP)
- Flights from Norfolk (ORF) to San Luis Obispo (SBP)
- Flights from Des Moines (DSM) to San Luis Obispo (SBP)
- Flights from Chico (CIC) to San Luis Obispo (SBP)
- Flights from Concord (CCR) to San Luis Obispo (SBP)
- Flights from North Bend (OTH) to San Luis Obispo (SBP)
- Flights from Corvallis (CVO) to San Luis Obispo (SBP)
- Flights from Monticello (MSV) to San Luis Obispo (SBP)
- Flights from Peoria (PIA) to San Luis Obispo (SBP)
- Flights from Washington (IAD) to San Luis Obispo (SBP)
- Flights from San Luis Obispo
- Flights from Santa Maria (SMX) to San Luis Obispo (SBP)
- Flights from Madrid (MAD) to San Luis Obispo (SBP)
- Flights from Casper (CPR) to San Luis Obispo (SBP)
- Flights from Blacksburg (BCB) to San Luis Obispo (SBP)
- Flights from Lübeck (LBC) to San Luis Obispo (SBP)