Find Luxury Hotels in Panama City

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Our top choices for Panama City luxury hotels

JW Marriott Panama

JW Marriott Panama
5.0 star property
San Francisco
9.0 out of 10, Wonderful, (1002)
"Bedroom was very comfy, also the staff were very on point. I will definitely recommend this hotel and there services, there is so much to do at this hotel."
United States
Sarran
The price is NT$10,342
NT$11,376 total
includes taxes & fees
Jan 4 - 2026/1/5
JW Marriott Panama

Bristol Panama, a Registry Collection Hotel

Bristol Panama, a Registry Collection Hotel
5.0 star property
Bella Vista
9.4 out of 10, Exceptional, (1000)
"Great staff, super accommodating. Best place to stay in Panama!"
United States
Sebastian
The price is NT$6,306
NT$6,936 total
includes taxes & fees
Jan 14 - 2026/1/15
Bristol Panama, a Registry Collection Hotel

Waldorf Astoria Panama

Waldorf Astoria Panama
5.0 star property
Bella Vista
9.0 out of 10, Wonderful, (1001)
"I loved everything about my stay "
United States
Stephanie
The price is NT$6,934
NT$7,627 total
includes taxes & fees
Jan 10 - 2026/1/11
Waldorf Astoria Panama

American Trade Hotel

American Trade Hotel
4.5 star property
Casco Viejo
9.4 out of 10, Exceptional, (607)
"Excellent service and great rooms on a beautiful and historical building"
Canada
Manuel
The price is NT$9,166
NT$10,083 total
includes taxes & fees
Jan 13 - 2026/1/14
American Trade Hotel

Sortis Hotel, Spa & Casino, Autograph Collection by Marriott

Sortis Hotel, Spa & Casino, Autograph Collection by Marriott
4.5 star property
Bella Vista
8.8 out of 10, Excellent, (1001)
"Everything was clean and the staff was very cooperative."
United States
Deangelo
The price is NT$4,998
NT$5,498 total
includes taxes & fees
Jan 5 - 2026/1/6
Sortis Hotel, Spa & Casino, Autograph Collection by Marriott

Hilton Panama

Hilton Panama
5.0 star property
Bella Vista
8.8 out of 10, Excellent, (1000)
"Nice room! Clean. Nice balcony, "
United States
Cassandra
The price is NT$6,333
NT$6,967 total
includes taxes & fees
Jan 10 - 2026/1/11
Hilton Panama

Megapolis Hotel Panamá

Megapolis Hotel Panamá
5.0 star property
San Francisco
8.4 out of 10, Very Good, (1000)
"Great stay! Very safe!"
United States
MARVIN
Megapolis Hotel Panamá

Manrey Boutique Hotel

Manrey Boutique Hotel
3.5 star property
Panama City
7.6 out of 10, Good, (255)
"Hotel was closed when we arrived. Had not told us about the closure so we had to scramble to find another hotel"
United States
Anonymous traveler
Manrey Boutique Hotel

Las Americas Golden Tower Panama

Las Americas Golden Tower Panama
4.0 star property
San Francisco
9.0 out of 10, Wonderful, (1000)
"I loved my stay! "
United States
Jenniffer Gonzalez De La
The price is NT$4,933
NT$5,426 total
includes taxes & fees
Jan 13 - 2026/1/14
Las Americas Golden Tower Panama

Marriott Panama Hotel

Marriott Panama Hotel
4.0 star property
Panama City
9.0 out of 10, Wonderful, (1000)
"Great hotel and staff!"
United States
Catherine
The price is NT$5,061
NT$5,567 total
includes taxes & fees
Jan 10 - 2026/1/11
Marriott Panama Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Panama City Hotel Reviews

Frequently asked questions

Are you searching for the perfect hotel for your luxury getaway to Panama City?
Arrange a flight into Panama City (PAC-Marcos A. Gelabert Intl.) Airport or Balboa (BLB-Panama Pacifico Intl.) Airport, and then treat yourself to a stay at one of 23 luxurious hotels. Known for its casinos and shopping, Panama City also has some interesting things to see and do including Albrook Shopping Mall, so you may want to take in the local sights during your visit.
What's the best luxury accommodation in Panama City?
Hotel Riu Plaza Panama is a luxury hotel with 3 restaurants and valet parking, and it's a popular choice for Expedia travelers looking for an elegant place to stay. Megapolis Hotel Panamá and W Panama are other upscale choices for your trip.
How many luxury hotels will I be able to find in Panama City?
Lie in the lap of luxury during your getaway to Panama City in one of Expedia's 23 luxury hotels.
When can I expect good weather in Panama City?
Planning for the weather is a good way to make your trip to Panama City relaxing and enjoyable, especially when you're splurging. The hottest months are usually March and April with an average temp of 80°F, while the coldest months are January and February with an average of 79°F. The rainiest months in Panama City are July, August, June, and November, with each month seeing an average of 15 inches of rainfall.
What's there to see and do in Panama City?
Experience Panama City and visit Albrook Shopping Mall, Via Espana, and Iglesia del Carmen. If you have spare time during your trip, you might want to make a stop at Uruguay Street and Crown Casino.
How can I get around Panama City?
It's easier to get around town in style when you know your options. You can walk to nearby metro stations including Iglesia del Carmen Station, Vía Argentina, and Santo Tomas Station. If you want to venture outside of the area, hop on a train at Panama City Passenger Station.