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Our top choices for Mayo Clinic hotels

Sonesta Select Scottsdale at Mayo Clinic Campus

Sonesta Select Scottsdale at Mayo Clinic Campus
3.0 star property
Mayo Clinic
8.2 out of 10, Very Good, (1065)
"Beautiful room, couteous and experienced front desk staff. Easiest check in."
United States
April
The price is NT$3,301
NT$3,762 total
includes taxes & fees
Jan 4 - 2026/1/5
Sonesta Select Scottsdale at Mayo Clinic Campus

Drury Inn & Suites Phoenix Airport

Drury Inn & Suites Phoenix Airport
3.0 star property
27.7 km from Mayo Clinic
9.6 out of 10, Exceptional, (2320)
"It was a great stay!"
United States
Nicholas
The price is NT$3,206
NT$3,625 total
includes taxes & fees
Jan 11 - 2026/1/12
Drury Inn & Suites Phoenix Airport

Hilton Garden Inn Phoenix Airport North

Hilton Garden Inn Phoenix Airport North
3.0 star property
24.2 km from Mayo Clinic
8.6 out of 10, Excellent, (2339)
"Easy check in and overall stay was nice and comfortable."
United States
David
The price is NT$3,067
NT$3,468 total
includes taxes & fees
Jan 2 - 2026/1/3
Hilton Garden Inn Phoenix Airport North

Holiday Inn Express & Suites Phoenix - Airport North by IHG

Holiday Inn Express & Suites Phoenix - Airport North by IHG
2.5 star property
23.1 km from Mayo Clinic
9.4 out of 10, Exceptional, (2156)
"Nice room, great breakfast and great price!"
United States
John
The price is NT$2,923
NT$3,306 total
includes taxes & fees
Jan 4 - 2026/1/5
Holiday Inn Express & Suites Phoenix - Airport North by IHG

La Quinta Inn & Suites by Wyndham Mesa Superstition Springs

La Quinta Inn & Suites by Wyndham Mesa Superstition Springs
3.0 star property
24.1 km from Mayo Clinic
8.2 out of 10, Very Good, (1797)
"I’ve stayed here multiple times and it’s always a great stay"
United States
dean
The price is NT$2,956
NT$3,378 total
includes taxes & fees
Dec 30 - Dec 31
La Quinta Inn & Suites by Wyndham Mesa Superstition Springs

Hyatt Place Phoenix/Mesa

Hyatt Place Phoenix/Mesa
3.0 star property
17.9 km from Mayo Clinic
9.2 out of 10, Wonderful, (1699)
"Cleanliness, location, comfortable bed, decent & delicious free breakfast & friendly staff. "
Canada
Jasmin
The price is NT$3,426
NT$3,915 total
includes taxes & fees
Dec 28 - Dec 29
Hyatt Place Phoenix/Mesa

Comfort Suites Scottsdale Talking Stick Entertainment District

Comfort Suites Scottsdale Talking Stick Entertainment District
2.5 star property
9.7 km from Mayo Clinic
9.2 out of 10, Wonderful, (1762)
"The property was easy to find, clean, the beds were comfortable and the free breakfast was good."
United States
Jackie
The price is NT$2,955
NT$3,369 total
includes taxes & fees
Dec 28 - Dec 29
Comfort Suites Scottsdale Talking Stick Entertainment District

SureStay Plus by Best Western Mesa Superstition Springs

SureStay Plus by Best Western Mesa Superstition Springs
2.5 star property
23.4 km from Mayo Clinic
8.4 out of 10, Very Good, (1668)
"Room was clean and staff very pleasant. "
United States
Jovana
The price is NT$2,483
NT$2,838 total
includes taxes & fees
Dec 28 - Dec 29
SureStay Plus by Best Western Mesa Superstition Springs

Hilton Phoenix Airport

Hilton Phoenix Airport
4.0 star property
24.9 km from Mayo Clinic
8.8 out of 10, Excellent, (1077)
"Overall very good stay"
United States
Steven
The price is NT$3,573
NT$4,040 total
includes taxes & fees
Jan 3 - 2026/1/4
Hilton Phoenix Airport

Home2 Suites by Hilton Scottsdale Old Town

Home2 Suites by Hilton Scottsdale Old Town
2.5 star property
Downtown Scottsdale, 16.7 km from Mayo Clinic
8.6 out of 10, Excellent, (1000)
"Nice hotel"
United States
Jessica
The price is NT$3,067
NT$3,496 total
includes taxes & fees
Jan 2 - 2026/1/3
Home2 Suites by Hilton Scottsdale Old Town

Best Western Downtown Phoenix

Best Western Downtown Phoenix
2.5 star property
29.3 km from Mayo Clinic
8.6 out of 10, Excellent, (1008)
"Clean room, excellent front desk staff. "
United States
Jennifer
The price is NT$2,912
NT$3,293 total
includes taxes & fees
Jan 2 - 2026/1/3
Best Western Downtown Phoenix

Hampton Inn by Hilton Carefree

Hampton Inn by Hilton Carefree
2.5 star property
29.2 km from Mayo Clinic
9.4 out of 10, Exceptional, (611)
"Friendly Staff, Pool Area, Good Price"
United States
John
The price is NT$3,815
NT$4,321 total
includes taxes & fees
Jan 25 - 2026/1/26
Hampton Inn by Hilton Carefree

Hilton Garden Inn Phoenix Airport

Hilton Garden Inn Phoenix Airport
3.0 star property
27.6 km from Mayo Clinic
8.8 out of 10, Excellent, (1000)
"The room was clean and staff was excellent. "
United States
arthur
The price is NT$2,880
NT$3,257 total
includes taxes & fees
Jan 11 - 2026/1/12
Hilton Garden Inn Phoenix Airport

Motel 6 Old town Scottsdale/Fashion Square

Motel 6 Old town Scottsdale/Fashion Square
2.0 star property
Fashion Square, 16 km from Mayo Clinic
7.8 out of 10, Good, (1048)
"Great place to stay!"
United States
Jeffrey
The price is NT$2,022
NT$2,305 total
includes taxes & fees
Dec 29 - Dec 30
Motel 6 Old town Scottsdale/Fashion Square

Papago Scottsdale by Reside, Trademark Collection by Wyndham

Papago Scottsdale by Reside, Trademark Collection by Wyndham
3.0 star property
18.5 km from Mayo Clinic
8.6 out of 10, Excellent, (270)
"A quiet, boutique hotel with a heated pool. I would stay there again. "
United States
matthew
The price is NT$2,805
NT$3,197 total
includes taxes & fees
Dec 28 - Dec 29
Papago Scottsdale by Reside, Trademark Collection by Wyndham

Hyatt Place Tempe Phoenix Airport

Hyatt Place Tempe Phoenix Airport
3.0 star property
23.5 km from Mayo Clinic
9.0 out of 10, Wonderful, (1058)
"I really enjoyed my stay. "
United States
Charles
The price is NT$3,112
NT$3,550 total
includes taxes & fees
Dec 28 - Dec 29
Hyatt Place Tempe Phoenix Airport

SpringHill Suites Phoenix Airport/Tempe

SpringHill Suites Phoenix Airport/Tempe
3.0 star property
23.5 km from Mayo Clinic
9.2 out of 10, Wonderful, (1005)
"Great breakfast safe area and the front desk was super nice and helpful. "
United States
Gloria
The price is NT$2,106
NT$2,402 total
includes taxes & fees
Jan 11 - 2026/1/12
SpringHill Suites Phoenix Airport/Tempe

La Quinta Inn & Suites by Wyndham Phoenix Scottsdale

La Quinta Inn & Suites by Wyndham Phoenix Scottsdale
3.0 star property
Central Scottsdale, 9 km from Mayo Clinic
8.8 out of 10, Excellent, (1791)
" Great stay."
United States
Mark
The price is NT$2,658
NT$3,029 total
includes taxes & fees
Dec 30 - Dec 31
La Quinta Inn & Suites by Wyndham Phoenix Scottsdale

The Azure Hotel

The Azure Hotel
2.5 star property
19.1 km from Mayo Clinic
8.8 out of 10, Excellent, (1623)
"Excellent location, rooms where clean, staff where great. All round an excellent stay and would recommend"
United Kingdom
Jacqueline
The Azure Hotel

Holiday Inn Express Hotel & Suites Phoenix North Scottsdale by IHG

Holiday Inn Express Hotel & Suites Phoenix North Scottsdale by IHG
2.5 star property
20.2 km from Mayo Clinic
9.0 out of 10, Wonderful, (1004)
"Good well managed hotel"
Canada
Jamie
The price is NT$3,046
NT$3,444 total
includes taxes & fees
Dec 28 - Dec 29
Holiday Inn Express Hotel & Suites Phoenix North Scottsdale by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Mayo Clinic

Find the best Mayo Clinic areas and neighborhoods for the activities you enjoy most.

Downtown Phoenix

A true urban neighborhood, Downtown Phoenix boasts major sports venues like Chase Field and Footprint Center, as well as cultural attractions such as the Arizona Science Center and Phoenix Art Museum. Easily accessible via Valley Metro Light Rail, enjoy walkable streets, friendly cafes, and local businesses.

Old Town

Old Town is known for its popular shops, and you can see some sights in the area like Western Spirit: Scottsdale's Museum of the West and Scottsdale Fashion Square.

Camelback East

Adjacent to Paradise Valley and Scottsdale, Camelback East Village boasts two main cores and sits between Piestewa Peak and Camelback Mountain. Explore the vibrant 24th Street and Camelback Road or 44th Street and Van Buren Street areas.

North Phoenix

While you're in North Phoenix, take in top sights like Reach 11 Sports Complex and jump on the metro at 19th Avenue/ Dunlap Station to see more of the city.

East Mesa

While you're in East Mesa, take in top sights like Salt River Tubing and jump on the metro at Superstition Springs Transit Center to see more of the city.

Top Mayo Clinic Hotel Reviews

Frequently asked questions

What is Mayo Clinic like?
Travelers will be sure to find plenty to entertain them in Scottsdale's Mayo Clinic neighborhood.
Where is the best place to stay in Mayo Clinic?
Based on Expedia customer reviews, Sonesta Select Scottsdale at Mayo Clinic Campus is the highest ranked property in Mayo Clinic. This hotel offers a restaurant and an outdoor pool.
How many hotels will I be able to find in the Mayo Clinic area?
With 14 Expedia hotels and other accommodations in Mayo Clinic to choose from, this is a good starting point for exploring the greater Scottsdale area.
If I need to cancel my hotel reservation in Mayo Clinic, will I receive a refund?
Yes! Most hotel reservations are fully refundable if you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you might be able to still cancel and receive a refund within a 24-hour period of booking. Add dates, click "Search", then use the filter option "fully refundable" to view the best deals in Mayo Clinic.
Where can I learn more about changing or cancelling my trip to Mayo Clinic?
For more information about updating your trip to Mayo Clinic or cancelling it, go to https://www.expedia.com/service/.
What is there to do around this Scottsdale neighborhood?
A few places to visit in the area around Mayo Clinic include Eagle Mountain Golf Course, Golf Club at Eagle Mountain, and SunRidge Canyon Golf Club. Make a stop at Talking Stick Resort Casino and OdySea Aquarium while you're sightseeing around the area.

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