Main Street Hyannis Tours

Main Street Hyannis which includes street scenes as well as a couple
Main Street Hyannis showing signage
Main Street Hyannis featuring street scenes as well as a couple
Main Street Hyannis
Main Street Hyannis showing signage

Plan a trip to see Main Street Hyannis

Price found within the past 48 hours. Click for updated prices.
Anchor In Distinctive Waterfront Lodging

Anchor In Distinctive Waterfront Lodging

3 out of 5
per person
Sep 17 - Sep 21
found 1 day ago
Roundtrip non-stop flight included
St. Louis (STL) to Hyannis (HYA)
9.4/10 Exceptional! (1,004 reviews)
The location was great and in walking distance to everything. The breakfast is almost all pre-packaged food. That was disappointing. The room was ok. I expect extremely clean rooms and was disappointed that when I moved the table and a few items , there were ketchup stains that had not been cleaned. I cleaned it and said nothing to the family. The woman who greeted us the first night was extremely friendly . Her name was Mary😊

Reviewed on 2025/7/22

Chapter House

Chapter House

3.5 out of 5
per person
Sep 17 - Sep 21
found 1 day ago
Roundtrip non-stop flight included
St. Louis (STL) to Hyannis (HYA)
9.2/10 Wonderful! (151 reviews)
The property was absolutely stunning. We also had a problem with the shower and having hot water and they immediately accommodated us by putting us in the main house. Wonderful stay!

Reviewed on 2025/7/13

Inn on Main

Inn on Main

3.5 out of 5
per person
Sep 17 - Sep 21
found 1 day ago
Roundtrip non-stop flight included
St. Louis (STL) to Hyannis (HYA)
10/10 Exceptional! (68 reviews)
Terrific B&B on Cape Cod - super dog friendly and very hospitable! Excellent breakfasts, charming space, and wonderful hosts. It’s a very convenient mid-Cape location, you will not regret booking with them.

Reviewed on 2025/5/10

Popular places to visit

John F. Kennedy Hyannis Museum showing a statue or sculpture

John F. Kennedy Hyannis Museum

Learn about the 35th president of the United States at this revealing museum, which is just a short distance from the Kennedy Compound.

John F. Kennedy Hyannis Museum
Hyannis

Cape Cod Maritime Museum

You can spend an afternoon exploring the galleries in Cape Cod Maritime Museum during your trip to Hyannis. Stroll along the seaside in this family-friendly area, or check out its seafood restaurants.

Cape Cod Maritime Museum
Hyannis

St. Francis Xavier Church

Learn about the local history of Hyannis with a stop at St. Francis Xavier Church. Amble around this family-friendly area's beautiful beaches and enjoy its seafood restaurants.

St. Francis Xavier Church
Hyannis Harbor which includes a sunset and a bay or harbor as well as a small group of people

Hyannis Harbor

See the Cape Cod peninsula from a different perspective by riding a boat out of this picturesque harbor or wandering along its docks and jetties.

Hyannis Harbor
John F. Kennedy Memorial

John F. Kennedy Memorial

Take a moment to reflect on John F. Kennedy’s defining role in American politics, as well as his untimely death, at this poignant memorial.

John F. Kennedy Memorial

Hyannis Armory

Learn about the local history of Hyannis when you take a trip to Hyannis Armory. Wander the waterfront and beautiful beaches in the area.

Hyannis Armory

Best Lodging Options Near Main Street Hyannis

Hyannis Harbor Hotel

Hyannis Harbor Hotel

3.5 out of 5
213 Ocean St, Hyannis, MA
Hyannis Harbor Hotel
Hyannis Plaza Hotel

Hyannis Plaza Hotel

2.5 out of 5
662 Main Street, Hyannis, MA
Hyannis Plaza Hotel
Hyannis Inn

Hyannis Inn

2 out of 5
473 MAIN ST, Hyannis, MA
Hyannis Inn
Americas Best Value Inn & Suites Hyannis Cape Cod

Americas Best Value Inn & Suites Hyannis Cape Cod

2 out of 5
206 Main St, Hyannis, MA
Americas Best Value Inn & Suites Hyannis Cape Cod
Hyannis Travel Inn

Hyannis Travel Inn

2.5 out of 5
18 North St, Hyannis, MA
Hyannis Travel Inn
Cape Sands Inn

Cape Sands Inn

2.5 out of 5
149 Main St - RT 28, West Yarmouth, MA
Cape Sands Inn
Comfort Inn Hyannis - Cape Cod

Comfort Inn Hyannis - Cape Cod

2.5 out of 5
259 Main Street, Hyannis, MA
Comfort Inn Hyannis - Cape Cod
Bayside Resort Hotel

Bayside Resort Hotel

3 out of 5
225 Route 28, West Yarmouth, MA
Bayside Resort Hotel
Heritage House Inn on Cape Cod

Heritage House Inn on Cape Cod

2.5 out of 5
540 Old Colony Rd, Hyannis, MA
Heritage House Inn on Cape Cod
See all 3,709 properties in Main Street Hyannis
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.