Find hotels in La Mesilla, NM from NT$2,393

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Dec 9 - Dec 10
Tomorrow
Dec 10 - Dec 11
This weekend
Dec 12 - Dec 14
Next weekend
Dec 19 - Dec 21

Filter by

Guest rating
Guest rating
Star rating

Our top choices for La Mesilla hotels

Free daily self-serve breakfast
Wingate by Wyndham Los Alamos

Wingate by Wyndham Los Alamos

2.5 star property
Los Alamos
8.0 out of 10, Very Good, (570)
"Solid hotel with very friendly and supportive staff. "
United States
Markus
The price is NT$2,331
NT$2,612 total
includes taxes & fees
Jan 4 - 2026/1/5
Wingate by Wyndham Los Alamos
Free daily buffet breakfast
Holiday Inn Express & Suites Los Alamos Entrada Park by IHG

Holiday Inn Express & Suites Los Alamos Entrada Park by IHG

2.5 star property
Los Alamos
8.8 out of 10, Excellent, (741)
"The room was spotless , all the employees are friendly and have great customer service. The breakfast is really good . "
United States
Claudia
The price is NT$3,804
NT$4,263 total
includes taxes & fees
Dec 14 - Dec 15
Holiday Inn Express & Suites Los Alamos Entrada Park by IHG
Free continental breakfast
Rodeway Inn Española

Rodeway Inn Española

2.0 star property
Espanola
6.2 out of 10, (466)
"Friendly staff, clean on the surface, appears to be in renovation stage, heat and air worked fine, lighted/fenced parking, filthy sheets, cigarette burned bed covers, no (soap, shampoo, conditioner, hair dryer), and breakfast was just coffee and oatmeal packets. This place is perfect as a homeless refuge or a 1 hour rental. Do yourself a favor and stay at one of the local casinos."
United States
M L
The price is NT$2,245
NT$2,552 total
includes taxes & fees
Dec 16 - Dec 17
Rodeway Inn Española
View from room
Days Inn by Wyndham Espanola

Days Inn by Wyndham Espanola

2.0 star property
Espanola
5.8 out of 10, (587)
"Good place to stay"
United States
Sergio
The price is NT$3,212
NT$3,651 total
includes taxes & fees
Jan 3 - 2026/1/4
Days Inn by Wyndham Espanola
Seasonal outdoor pool, open 9:00 AM to 10:00 PM, pool umbrellas
Hotel Glorieta

Hotel Glorieta

3.5 star property
Santa Fe
8.0 out of 10, Very Good, (39)
"Loved the decor"
United States
Marian
The price is NT$2,947
NT$4,292 total
includes taxes & fees
Jan 5 - 2026/1/6
Hotel Glorieta
Suite, 1 King Bed | View from room
Hilton Santa Fe Buffalo Thunder

Hilton Santa Fe Buffalo Thunder

4.0 star property
Santa Fe
8.6 out of 10, Excellent, (1001)
"I love staying here, the golf and Casino, restaurants, spa are all amazing!"
United States
JESSICA
The price is NT$3,207
NT$3,666 total
includes taxes & fees
Dec 16 - Dec 17
Hilton Santa Fe Buffalo Thunder
Bar (on property)
Ohkay Casino Resort Hotel

Ohkay Casino Resort Hotel

2.5 star property
Ohkay Owingeh
8.0 out of 10, Very Good, (787)
"Clean rooms and excellent service "
United States
Patrick
Ohkay Casino Resort Hotel
Restaurant
Homewood Suites by Hilton Santa Fe-North

Homewood Suites by Hilton Santa Fe-North

3.0 star property
Santa Fe
9.2 out of 10, Wonderful, (1000)
"Good breakfast, clean, staff friendly "
United States
KIMTHU
The price is NT$3,542
NT$4,049 total
includes taxes & fees
Jan 7 - 2026/1/8
Homewood Suites by Hilton Santa Fe-North
In-room safe, iron/ironing board, free WiFi, bed sheets
Hampton Inn & Suites Los Alamos White Rock

Hampton Inn & Suites Los Alamos White Rock

2.5 star property
Los Alamos
9.0 out of 10, Wonderful, (674)
"Nice place "
United States
Laura
The price is NT$3,467
NT$3,886 total
includes taxes & fees
Dec 17 - Dec 18
Hampton Inn & Suites Los Alamos White Rock
Lobby sitting area
Cities Of Gold Casino

Cities Of Gold Casino

3.0 star property
Santa Fe
8.0 out of 10, Very Good, (1065)
"Always love staying here everything was good"
United States
Rafael
The price is NT$2,094
NT$2,393 total
includes taxes & fees
Jan 9 - 2026/1/10
Cities Of Gold Casino
Exterior
Bishop's Lodge, Auberge Collection

Bishop's Lodge, Auberge Collection

5.0 star property
Tesuque
9.4 out of 10, Exceptional, (89)
"Great location, Resort, amenities, excellent service and great restaurant chef!!!!!"
United States
James R
Bishop's Lodge, Auberge Collection
Spa
Motel 6 Espanola, NM

Motel 6 Espanola, NM

2.0 star property
Espanola
6.4 out of 10, (517)
"One of the cleanest motels I’ve been in a long time. The water was hot. It was good and they provided coffee. I will definitely stay here again."
United States
Sally
The price is NT$2,775
NT$3,155 total
includes taxes & fees
Jan 6 - 2026/1/7
Motel 6 Espanola, NM
Terrace/patio
Four Seasons Resort Rancho Encantado Santa Fe

Four Seasons Resort Rancho Encantado Santa Fe

5.0 star property
Santa Fe
9.4 out of 10, Exceptional, (265)
"Food options were good, but limited. The scenery was breathtaking as well as the nearby Santa Fe and the tours we took to the Indian reservation and Los Alamos"
United States
ILAN
The price is NT$16,215
NT$20,140 total
includes taxes & fees
Dec 16 - Dec 17
Four Seasons Resort Rancho Encantado Santa Fe
Property grounds
The Inn at the Delta

The Inn at the Delta

3.0 star property
Espanola
9.4 out of 10, Exceptional, (1000)
"The room was very clean with plenty of space. Nice and quiet area. Really enjoyed our 3 night stay."
United Kingdom
Taco
The Inn at the Delta
Exterior
Casa Escondida Bed & Breakfast

Casa Escondida Bed & Breakfast

3.0 star property
Chimayo
9.4 out of 10, Exceptional, (262)
"Beautiful historic property. Great staff and excellent breakfast. "
United States
Julie
The price is NT$3,704
NT$4,135 total
includes taxes & fees
Dec 11 - Dec 12
Casa Escondida Bed & Breakfast
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top La Mesilla Hotel Reviews

Hilton Santa Fe Buffalo Thunder

Hilton Santa Fe Buffalo Thunder

10/10 Excellent
"Did not have a problem checking in"
Patricia 1-night trip
Posted 2 days ago
Hilton Santa Fe Buffalo Thunder

More cheap stays in La Mesilla

Wingate by Wyndham Los Alamos

Wingate by Wyndham Los Alamos

2455 Trinity Dr Los Alamos NM
The price is NT$2,331 per night from Jan 4 to Jan 5
NT$2,331
NT$2,612 total
Jan 4 - 2026/1/5
includes taxes & fees
8/10 Very Good! (568 reviews)

Hotels in La Mesilla with star-rating

Frequently asked questions

What's the best place for a stay in La Mesilla?
Located 7.4 mi (11.9 km) from the heart of La Mesilla, Hilton Santa Fe Buffalo Thunder is a top choice for your stay based on our traveler data. Other good choices for your visit to the area are Cities Of Gold Casino and Bishop's Lodge, Auberge Collection. See all available top hotels, or vacation rentals in La Mesilla.
What are some of the best vacation home rentals in La Mesilla?
Cielo Grande: This vacation home rental near La Mesilla is located near the beach and has a fireplace, a balcony, and air-conditioning to put you at ease in your new surroundings. Kitchen amenities include a dishwasher, a fridge, and a stovetop. See all vacation rentals in La Mesilla.
If I need to cancel my hotel reservation in La Mesilla, will I receive a refund?
Yes, most hotel room reservations are fully refundable provided that you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of your check-in date. If you have a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in La Mesilla.
Where can I learn more about changing or cancelling my trip to La Mesilla?
To access more information about updating your trip to La Mesilla or cancelling it, head over to our customer service page.
What is staying in La Mesilla like?
Visitors are sure to enjoy all that La Mesilla has to offer. There are 386 hotels and other accommodations in the surrounding area. Find out more about La Mesilla.
What should I do while I'm visiting La Mesilla?
Places to visit in the wider area include Cities of Gold Casino, Buffalo Thunder Resort and Casino, and Santuario de Chimayo. You'll also find Lowlows Lowrider Art Place and Puye Cliff Dwellings in the area. Check out what more to see and do in Expedia's La Mesilla guide.
What's the weather like in La Mesilla?
The hottest months are usually July and June with an average temp of 70°F, while the coldest months are January and December with an average of 33°F. The snowiest months in La Mesilla are March, January, December, and February, with each month seeing an average of 9 inches of snowfall.

Explore a world of travel with Expedia