Lodging Image

Find hotels in Isle of Palms, Jacksonville

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Aug 7 - Aug 9
Next weekend
Aug 14 - Aug 16

Filter by

Star rating

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Our top choices for Isle of Palms hotels

Lobby

1. Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area
3.0 star property
Isle of Palms
9.4 out of 10, Exceptional, (570 reviews)
"Great prices for the rooms and amenities they come with. Best hotel breakfast Ive seen in a while- all the extras and more!"
United States
Laura
The price is NT$4,416
NT$5,012 total
includes taxes & fees
Sep 6 - Sep 7
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
Lobby

2. Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
2.5 star property
3 km from Isle of Palms
9.0 out of 10, Wonderful, (1,009 reviews)
"Nice friendly hotel. Front desk so delightful, the breakfast staff goes above and beyond making sure everything is filled for breakfast ."
United States
Grace
The price is NT$4,131
NT$4,689 total
includes taxes & fees
Aug 9 - Aug 10
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
Lobby sitting area

3. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
2.5 star property
3.9 km from Isle of Palms
9.0 out of 10, Wonderful, (1,007 reviews)
"Very helpful staff and nice view to the golf course."
United States
Jorge
The price is NT$3,424
NT$3,886 total
includes taxes & fees
Sep 6 - Sep 7
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
Terrace/patio

4. TownePlace Suites by Marriott Jacksonville East

TownePlace Suites by Marriott Jacksonville East
3.0 star property
3 km from Isle of Palms
9.2 out of 10, Wonderful, (644 reviews)
"Clean place"
United States
grant
The price is NT$3,844
NT$4,363 total
includes taxes & fees
Sep 6 - Sep 7
TownePlace Suites by Marriott Jacksonville East
Sports facility

5. Hyatt Place Jacksonville / St. Johns Town Center

Hyatt Place Jacksonville / St. Johns Town Center
3.0 star property
9.7 km from Isle of Palms
9.2 out of 10, Wonderful, (1,167 reviews)
"Clean rooms, welcoming staff, and good breakfast/coffee."
United States
Rana
The price is NT$4,361
NT$4,950 total
includes taxes & fees
Sep 1 - Sep 2
Hyatt Place Jacksonville / St. Johns Town Center
Breakfast, lunch and dinner served

6. Hilton Jacksonville at Mayo Clinic near Beaches

Hilton Jacksonville at Mayo Clinic near Beaches
4.5 star property
2.1 km from Isle of Palms
9.4 out of 10, Exceptional, (308 reviews)
"Great hotel and very convenient to Mayo."
United States
Margaret
The price is NT$5,006
NT$5,682 total
includes taxes & fees
Sep 6 - Sep 7
Hilton Jacksonville at Mayo Clinic near Beaches
Lobby

7. Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach
2.5 star property
Oceanfront, 4.6 km from Isle of Palms
9.0 out of 10, Wonderful, (4,297 reviews)
"Excellent place to stay"
United States
stephen
The price is NT$4,821
NT$5,472 total
includes taxes & fees
Aug 9 - Aug 10
Margaritaville Jacksonville Beach
Desk, blackout drapes, iron/ironing board (on request), cribs (free)

8. Hyatt Studios Jacksonville/St Johns Town Center

Hyatt Studios Jacksonville/St Johns Town Center
2.5 star property
8.9 km from Isle of Palms
9.6 out of 10, Exceptional, (150 reviews)
"Ladies at the front desk were amazing! Very happy with our stay "
United States
Kate
The price is NT$3,553
NT$4,033 total
includes taxes & fees
Aug 14 - Aug 15
Hyatt Studios Jacksonville/St Johns Town Center
Lobby

9. Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass
3.0 star property
8.7 km from Isle of Palms
9.2 out of 10, Wonderful, (1,007 reviews)
"Family of 5 stayed comfortably! Very accommodating and friendly! Room was clean, pool was also fun!"
United States
Brooke
The price is NT$4,147
NT$4,624 total
includes taxes & fees
Sep 6 - Sep 7
Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass
Property amenity

10. Sheraton Jacksonville Hotel

Sheraton Jacksonville Hotel
4.0 star property
10.7 km from Isle of Palms
9.0 out of 10, Wonderful, (1,002 reviews)
"The property was very clean and well maintained will stay there for any future stays."
United States
keren
The price is NT$3,995
NT$4,534 total
includes taxes & fees
Aug 14 - Aug 15
Sheraton Jacksonville Hotel
Property amenity

11. Element by Marriott Jacksonville Beach

Element by Marriott Jacksonville Beach
3.0 star property
Oceanfront, 4.2 km from Isle of Palms
9.6 out of 10, Exceptional, (573 reviews)
"Best hotel ever 😊"
United States
Tablo
The price is NT$5,201
NT$5,903 total
includes taxes & fees
Sep 6 - Sep 7
Element by Marriott Jacksonville Beach
Exterior

12. Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
2.5 star property
3.7 km from Isle of Palms
9.0 out of 10, Wonderful, (1,197 reviews)
"Attentive and friendly staff, good location, generous breakfast"
Canada
Dagmar Maria
The price is NT$3,872
NT$4,394 total
includes taxes & fees
Sep 1 - Sep 2
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
Exterior

13. Holiday Inn Express & Suites Jacksonville - Town Center by IHG

Holiday Inn Express & Suites Jacksonville - Town Center by IHG
2.5 star property
8.7 km from Isle of Palms
9.6 out of 10, Exceptional, (1,007 reviews)
"Hotel was very well kept. Enjoyed the stay"
United States
Satish
The price is NT$4,513
NT$5,122 total
includes taxes & fees
Aug 23 - Aug 24
Holiday Inn Express & Suites Jacksonville - Town Center by IHG
Exterior

14. Holiday Inn Jacksonville E 295 Baymeadows by IHG

Holiday Inn Jacksonville E 295 Baymeadows by IHG
3.0 star property
9.8 km from Isle of Palms
8.6 out of 10, Excellent, (1,003 reviews)
"The front desk, staff and the staff Doing the breakfast were awesome. We will definitely stay there again."
United States
Fred
The price is NT$3,133
NT$3,556 total
includes taxes & fees
Aug 13 - Aug 14
Holiday Inn Jacksonville E 295 Baymeadows by IHG
Exterior

15. Homewood Suites by Hilton Jacksonville-South/St. Johns Ctr.

Homewood Suites by Hilton Jacksonville-South/St. Johns Ctr.
3.0 star property
9.1 km from Isle of Palms
8.6 out of 10, Excellent, (1,001 reviews)
"The room was very clean and I really enjoyed my stay and I look forward to future stays at this loc"
United States
Eddie
The price is NT$3,130
NT$3,552 total
includes taxes & fees
Sep 6 - Sep 7
Homewood Suites by Hilton Jacksonville-South/St. Johns Ctr.
Bar (on property)

16. Springhill Suites By Marriott Jacksonville Beach Oceanfront

Springhill Suites By Marriott Jacksonville Beach Oceanfront
4.0 star property
Oceanfront, 4.5 km from Isle of Palms
9.0 out of 10, Wonderful, (762 reviews)
"Wonderful property with a great location and friendly staff! I’ve stayed at many Jax beach properties and always go back to this one."
United States
Elizabeth
The price is NT$6,013
NT$6,825 total
includes taxes & fees
Aug 16 - Aug 17
Springhill Suites By Marriott Jacksonville Beach Oceanfront
Snack bar

17. Tru By Hilton Jacksonville St Johns Town Center

Tru By Hilton Jacksonville St Johns Town Center
2.5 star property
9.7 km from Isle of Palms
9.2 out of 10, Wonderful, (935 reviews)
"Love it here! Staff is so friendly, rooms are clean and comfortable. I stay here often as my preferred choice for work trips! Free parking is a PLUS!"
United States
Tierra
The price is NT$3,537
NT$4,014 total
includes taxes & fees
Aug 16 - Aug 17
Tru By Hilton Jacksonville St Johns Town Center
On the beach

18. Best Western Oceanfront

Best Western Oceanfront
3.0 star property
Oceanfront, 4.4 km from Isle of Palms
9.0 out of 10, Wonderful, (1,002 reviews)
"Great location! Beach view , clean and friendly"
United States
Jasmine
The price is NT$4,215
NT$4,784 total
includes taxes & fees
Aug 9 - Aug 10
Best Western Oceanfront
Free daily continental breakfast

19. Fairfield Inn & Suites by Marriott Jacksonville Beach

Fairfield Inn & Suites by Marriott Jacksonville Beach
3.0 star property
Oceanfront, 5 km from Isle of Palms
8.6 out of 10, Excellent, (970 reviews)
"Very close to the beach, plenty of restaurants and shopping within a close distance. We will definitely be back there!"
United States
Xaviera
The price is NT$4,640
NT$5,267 total
includes taxes & fees
Aug 26 - Aug 27
Fairfield Inn & Suites by Marriott Jacksonville Beach
Lobby

20. Embassy Suites by Hilton Jacksonville Baymeadows

Embassy Suites by Hilton Jacksonville Baymeadows
3.5 star property
14.2 km from Isle of Palms
8.4 out of 10, Very Good, (1,470 reviews)
"The breakfast was great, the staff friendly and helpful."
United States
Joyce
The price is NT$4,212
NT$4,780 total
includes taxes & fees
Aug 13 - Aug 14
Embassy Suites by Hilton Jacksonville Baymeadows
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Isle of Palms

Find the best Isle of Palms areas and neighborhoods for the activities you enjoy most.
A coastal cityscape at dusk with a prominent clock tower, waterfront, and historic buildings.

Amelia City

While visiting Amelia City, you might make a stop by sights like American Beach and Fernandina Beach.

A sunset over a beach with waves and a pier.

Oceanfront

If you're spending some time in Oceanfront, Oceanfront Park and Northeast Florida Beaches are top sights worth seeing.

A city skyline with modern skyscrapers, a prominent Wells Fargo building, and a blue bridge over a river.
Photo by Ryan Ketterman
Open Photo by Ryan Ketterman

Downtown Jacksonville

Historic core with major corporations, Downtown Jacksonville offers diverse culinary and nightlife experiences at The Elbow. Explore attractions like Florida Theatre, TIAA Bank Field, and museums, while enjoying convenient transportation options.

A city skyline at night with illuminated buildings and a bridge reflecting on the water.

Southside

If you're spending some time in Southside, St. Johns Town Center and Orange Park Place Shopping Center are top sights worth seeing.

A golf course with a pond, trees, and buildings in the background.

Sawgrass

Visitors to Sawgrass like its beaches and riverfront, and Mickler Beach is a sight worth a stop.

Top Isle of Palms Hotel Reviews

Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach

10/10 Excellent
"The room was fantastic but need better bedding The view was amazing. I was able to see the Dolphins, sharks and boats from the balcony Only complaint windows needed cleaning Someone wrote wash me on the window and you could see it when the sun came up Loved watching the sunrise. Overall great experience. Want to come again."
Octavia 4-night trip
Posted 9 hours ago
Margaritaville Jacksonville Beach

Frequently asked questions

What is Isle of Palms like?
Travelers are sure to enjoy a stay in Jacksonville Beach's Isle of Palms neighborhood.
What's a favorite place to stay in Isle of Palms?
Based on our traveler data, Residence Inn By Marriott Jacksonville - Mayo Clinic Area is one of the top choices for your stay in Isle of Palms. This hotel is a short 6-minute walk from Mayo Clinic Florida, and it offers free breakfast and an outdoor pool.
How many hotels can I expect to find in Isle of Palms?
Expedia has 39 hotels and other accommodations in Isle of Palms to choose from, making this an ideal home base for exploring the greater Jacksonville Beach area.
If I need to cancel my hotel reservation in Isle of Palms, will I receive a refund?
Yes, you'll find most hotel reservations are refundable if you cancel before the hotel's cancellation deadline, which is often 24 or 48 hours before your arrival date. If you have a reservation that's non-refundable, it might still be possible to cancel it and receive a refund within 24 hours of booking. Add your dates and click on "Search", then use the "fully refundable" filter to get top deals in Isle of Palms.
Where can I learn more about changing or cancelling my trip to Isle of Palms?
For more information about changing or cancelling your trip to Isle of Palms, head over to our customer service page.
What is there to do in this Jacksonville Beach neighborhood?
A few places to visit in the area around Isle of Palms include Cradle Creek Preserve, Jacksonville Beach Golf Club, and Windsor Parke Golf Club. While you're out sightseeing in Jacksonville Beach, be sure to visit other sights like Players by the Sea or Rhoda Martin Cultural Heritage Center.

Explore a world of travel with Expedia