Top Isle of Palms Hotels from NT$2,866

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Our top choices for Isle of Palms hotels

An outdoor patio area with seating and a central fire feature, surrounded by buildings and palm trees.

1. Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Isle of Palms

Eladio

NT$5,112 total

includes taxes & fees

Nov 27 - Nov 28

A modern lobby with a curved sofa, round coffee tables, and a large pillar.

2. Hilton Jacksonville at Mayo Clinic near Beaches

2.1 km from Isle of Palms

Brandy

NT$5,944 total

includes taxes & fees

Nov 22 - Nov 23

A hotel lobby with a bar area, seating arrangements, and a reception desk.

3. Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

3 km from Isle of Palms

Kerry

NT$4,770 total

includes taxes & fees

Nov 22 - Nov 23

A hotel room with a microwave, coffee maker, and refrigerator on the counter. There is a door with a sign and a towel rack visible.

4. Holiday Inn Express Jacksonville Beach by IHG

3.3 km from Isle of Palms

John

NT$4,263 total

includes taxes & fees

Nov 23 - Nov 24

An outdoor seating area with a fire pit, wicker furniture, and a covered patio.

5. TownePlace Suites by Marriott Jacksonville East

3 km from Isle of Palms

Lana

NT$4,588 total

includes taxes & fees

Nov 22 - Nov 23

An outdoor patio with seating, a fire pit, and string lights.

6. Hyatt Place Jacksonville / St. Johns Town Center

9.7 km from Isle of Palms

Lashonda

NT$4,148 total

includes taxes & fees

Nov 19 - Nov 20

A multi-story hotel with balconies, a pool area, and a restaurant.

7. Margaritaville Jacksonville Beach

Oceanfront, 4.6 km from Isle of Palms

Lavorus

NT$5,497 total

includes taxes & fees

Nov 15 - Nov 16

8. Hyatt Studios Jacksonville/St Johns Town Center

8.9 km from Isle of Palms

William

NT$4,330 total

includes taxes & fees

Nov 18 - Nov 19

A self-service beverage station with a refrigerated display and a coffee machine.

9. Tru By Hilton Jacksonville St Johns Town Center

9.7 km from Isle of Palms

Janice

NT$3,809 total

includes taxes & fees

Nov 22 - Nov 23

A modern living room with a grey sofa, armchairs, and a coffee table. Large windows offer a view of palm trees and buildings.

10. Element by Marriott Jacksonville Beach

Oceanfront, 4.2 km from Isle of Palms

Lisa

NT$5,669 total

includes taxes & fees

Nov 22 - Nov 23

A beach with a sandy shore, waves, and buildings in the background.

11. Best Western Oceanfront

Oceanfront, 4.4 km from Isle of Palms

Williams

NT$4,595 total

includes taxes & fees

Dec 1 - Dec 2

A terrace with wooden tables and chairs, overlooking a beach and a pier.

12. Springhill Suites By Marriott Jacksonville Beach Oceanfront

Oceanfront, 4.5 km from Isle of Palms

emily

NT$6,309 total

includes taxes & fees

Nov 22 - Nov 23

A hotel entrance with a 'welcome' sign, a palm tree, and a building with multiple windows.

13. Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

3.7 km from Isle of Palms

Jeffrey

NT$4,482 total

includes taxes & fees

Nov 22 - Nov 23

A Holiday Inn Express & Suites building with a central entrance, multiple windows, and a parking lot in front.

14. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

3.9 km from Isle of Palms

Alfredo

NT$4,113 total

includes taxes & fees

Nov 22 - Nov 23

An outdoor patio area with wicker furniture, a fire feature, and string lights.

15. Sheraton Jacksonville Hotel

10.7 km from Isle of Palms

Jarvon

NT$4,066 total

includes taxes & fees

Nov 19 - Nov 20

A buffet with various food options including potatoes, bacon, and a variety of fruits and vegetables.

16. Holiday Inn Jacksonville E 295 Baymeadows by IHG

9.8 km from Isle of Palms

Josh

NT$3,253 total

includes taxes & fees

Dec 13 - Dec 14

A spacious hotel atrium with multiple floors, a central staircase, and lush indoor plants.

17. Embassy Suites by Hilton Jacksonville Baymeadows

14.2 km from Isle of Palms

ROSA ISELA

NT$4,407 total

includes taxes & fees

Dec 6 - Dec 7

An outdoor seating area with colorful striped sofas and chairs, a fire pit, and a checkered floor pattern.

18. Home2 Suites by Hilton Jacksonville-South/St. Johns Town Ctr

10.3 km from Isle of Palms

Dana

NT$4,418 total

includes taxes & fees

Dec 11 - Dec 12

A modern lobby with a fireplace, a round table, and two green cushioned chairs.

19. Fairfield Inn & Suites by Marriott Jacksonville Beach

Oceanfront, 5 km from Isle of Palms

Daniel

NT$5,337 total

includes taxes & fees

Nov 22 - Nov 23

A modern hallway with a display of fossils, potted plants, and a clean, minimalist design.

20. AC Hotel Jacksonville St Johns Town Center

9.1 km from Isle of Palms

Dayana

NT$5,558 total

includes taxes & fees

Nov 22 - Nov 23

View all properties

Compare popular hotels in Isle of Palms

Property	Property class	Guest rating
Residence Inn By Marriott Jacksonville - Mayo Clinic Area	3.0 star property	9.4 Exceptional 623 reviews	View
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic	2.5 star property	9.0 Wonderful 1,003 reviews	View
Holiday Inn Express Jacksonville Beach by IHG	3.0 star property	9.2 Wonderful 1,002 reviews	View
Hilton Jacksonville at Mayo Clinic near Beaches	4.5 star property	9.2 Wonderful 392 reviews	View
TownePlace Suites by Marriott Jacksonville East	3.0 star property	9.2 Wonderful 669 reviews	View

Where to stay in Isle of Palms

Find the best Isle of Palms areas and neighborhoods for the activities you enjoy most.

A city skyline with modern skyscrapers, a prominent Wells Fargo building, and a blue bridge over a river.

Downtown Jacksonville

Historic core with major corporations, Downtown Jacksonville offers diverse culinary and nightlife experiences at The Elbow. Explore attractions like Florida Theatre, TIAA Bank Field, and museums, while enjoying convenient transportation options.

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A coastal cityscape at dusk with a prominent clock tower, waterfront, and historic buildings.

Amelia City

While visiting Amelia City, you might make a stop by sights like American Beach and Fernandina Beach.

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A sunset over a beach with waves and a pier.

Oceanfront

If you're spending some time in Oceanfront, Oceanfront Park and Northeast Florida Beaches are top sights worth seeing.

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A city skyline at night with illuminated buildings and a bridge reflecting on the water.

Southside

If you're spending some time in Southside, St. Johns Town Center and Orange Park Place Shopping Center are top sights worth seeing.

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A golf course with a pond, trees, and buildings in the background.

Sawgrass

Visitors to Sawgrass like its beaches and riverfront, and Mickler Beach is a sight worth a stop.

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Top Isle of Palms Hotel Reviews

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Isle of Palms

10/10 Excellent

Katherine

Holiday Inn Express Jacksonville Beach by IHG

Jacksonville Beach

10/10 Excellent

Jessica

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Jacksonville

10/10 Excellent

David

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Golden Glades - The Woods

10/10 Excellent

Richard

A multi-story hotel with a modern design, featuring a covered entrance and a parking area with handicapped accessibility.

Holiday Inn Express & Suites Jacksonville - Town Center by IHG

Southside

10/10 Excellent

Janice

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

Jacksonville Beach

10/10 Excellent

Markham

TownePlace Suites by Marriott Jacksonville East

Golden Glades - The Woods

10/10 Excellent

This property was in a convenient location between the college/university campuses and the beach. In addition to coffee shops and restaurants, there were plenty of shopping options within a few miles of the hotel. The rooms were quiet and the property was clean. The pool area was stocked with towels and comfortable reclining pool chairs. The only negative was that the pool was not heated. I would definitely stay at this property again!

Susan

Hyatt Place Jacksonville / St. Johns Town Center

Southside

10/10 Excellent

Not the easiest accessibility wise. Beautiful hotel but difficult to traverse with a physical disability. The parking is “far away” across from the hotel and not much parking, to be honest. I just needed a layover time to sleep and the beds were kind of rough, very firm but not terrible. It wasn’t all horrible, it was a very clean hotel with very clean rooms. It was just an accessible nightmare.

Kathy

Best Western Oceanfront

Oceanfront

10/10 Excellent

Room was very clean, which we so much appreciated!! Hot breakfast covered all the bases from fruit,eggs,made to order waffles,French toast,bagels muffins, juices coffee and oatmeal,biscuits and gravy. the location was close by the Mayo clinic. The only thing I did not like was the 13.00 per day parking fee. The parking was on site, so I feel the charge was just a money grab!! But overall I was pleased with my stay, exceeded my expectations!!

Christopher D.

A resort with a pool, palm trees, and a view of the beach.

Hampton Inn Jacksonville Beach/Oceanfront

Oceanfront

10/10 Excellent

By far, best feature of the hotel is the pool area - it did not disappoint. Compared to so many other hotels, this pool has fun waterfalls which also provided shade. For the weekend we were there, it never felt crowded because the area in and around the pool is spacious. Loved how breakfast was a little different each morning - plenty of options. Never seemed like anything was running out. The bar and grill had great conch fritters - husband ordered them twice. Room was pretty typical but...

Christine

Element by Marriott Jacksonville Beach

Oceanfront

10/10 Excellent

Booked this hotel based on reviews and location too. Reserved day of and didn’t get my requests (top floor, view of ocean)….but the design is so good - spacious rooms with no stale hotel smell - that I was ok with a middle floor. Hotel was quiet, clean and very well thought out. I don’t think it was full so not sure why I didn’t get my requests (view of parking lot instead)…but the Millennial vibes were appreciated. Lack of carpet, full kitchen, wood accents. Simple and elegant for a mid grade...

Anonymous traveler

Tru By Hilton Jacksonville St Johns Town Center

Southside

10/10 Excellent

Anonymous traveler

Holiday Inn Jacksonville E 295 Baymeadows by IHG

Deerwood

10/10 Excellent

Sandra

An indoor dining area with tables and chairs, a ceiling fan, and a view of the outdoors.

Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

Palm Valley

10/10 Excellent

Eloise

Sheraton Jacksonville Hotel

Southside

10/10 Excellent

Linda

Frequently Asked Questions

What is Isle of Palms like?

Travelers are sure to enjoy a stay in Jacksonville Beach's Isle of Palms neighborhood.

What's a favorite place to stay in Isle of Palms?

Based on our traveler data, Residence Inn By Marriott Jacksonville - Mayo Clinic Area is one of the top choices for your stay in Isle of Palms. This hotel is a short 6-minute walk from Mayo Clinic Florida, and it offers free breakfast and an outdoor pool.

How many hotels can I expect to find in Isle of Palms?

Expedia has 37 hotels and other accommodations in Isle of Palms to choose from, making this an ideal home base for exploring the greater Jacksonville Beach area.

If I need to cancel my hotel reservation in Isle of Palms, will I receive a refund?

Yes, you'll find most hotel reservations are refundable if you cancel before the hotel’s cancellation deadline, which is often 24 or 48 hours before your arrival date. If you have a reservation that's non-refundable, it might still be possible to cancel it and receive a refund within 24 hours of booking. Add your dates and click on "Search", then use the "fully refundable" filter to get top deals in Isle of Palms.

Where can I learn more about changing or cancelling my trip to Isle of Palms?

For more information about changing or cancelling your trip to Isle of Palms, head over to our customer service page.

What is there to do in this Jacksonville Beach neighborhood?

A few places to visit in the area around Isle of Palms include Cradle Creek Preserve, Jacksonville Beach Golf Club, and Windsor Parke Golf Club. While you're out sightseeing in Jacksonville Beach, be sure to visit other sights like Players by the Sea or Rhoda Martin Cultural Heritage Center.

Find hotels in Isle of Palms, Jacksonville from NT$2,866

Change your mind

Treat yourself

Be picky

Check prices for these dates

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Property class

Guest rating

Our top choices for Isle of Palms hotels

1. Residence Inn By Marriott Jacksonville - Mayo Clinic Area

2. Hilton Jacksonville at Mayo Clinic near Beaches

3. Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

4. Holiday Inn Express Jacksonville Beach by IHG

5. TownePlace Suites by Marriott Jacksonville East

6. Hyatt Place Jacksonville / St. Johns Town Center

7. Margaritaville Jacksonville Beach

8. Hyatt Studios Jacksonville/St Johns Town Center

9. Tru By Hilton Jacksonville St Johns Town Center

10. Element by Marriott Jacksonville Beach

11. Best Western Oceanfront

12. Springhill Suites By Marriott Jacksonville Beach Oceanfront

13. Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

14. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

15. Sheraton Jacksonville Hotel

16. Holiday Inn Jacksonville E 295 Baymeadows by IHG

17. Embassy Suites by Hilton Jacksonville Baymeadows

18. Home2 Suites by Hilton Jacksonville-South/St. Johns Town Ctr

19. Fairfield Inn & Suites by Marriott Jacksonville Beach

20. AC Hotel Jacksonville St Johns Town Center

Compare popular hotels in Isle of Palms

Where to stay in Isle of Palms

Downtown Jacksonville

Amelia City

Oceanfront

Southside

Sawgrass

Top Isle of Palms Hotel Reviews

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

10/10 Excellent

Frequently Asked Questions

What is Isle of Palms like?

What's a favorite place to stay in Isle of Palms?

How many hotels can I expect to find in Isle of Palms?

If I need to cancel my hotel reservation in Isle of Palms, will I receive a refund?

Where can I learn more about changing or cancelling my trip to Isle of Palms?

What is there to do in this Jacksonville Beach neighborhood?

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