Vacation Homes in Central San Diego
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A historic cathedral with intricate architecture, a prominent bell tower, and a blue-domed structure.

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Explore the seaside area of Central San Diego—a zoo, sports teams, and popular sights like San Diego Zoo.

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Top reviews in Central San Diego

A bar area with a glass ceiling, a central bar counter, and multiple stools.

A checkered floor with round tables and chairs, a patterned ceiling, and large windows.

A luxurious interior with a large chandelier, patterned sofas, and a view of a cityscape through a large window.

A large swimming pool with lounge chairs and umbrellas, surrounded by palm trees and a building with a striped facade.

Lafayette Hotel & Club

University Heights

10/10 Excellent

Absolutely amazing!!! This hotel is beautiful, stylish and very comfortable. We enjoyed the pool, diner, bar and jazz show. It is more than just a hotel stay, it is a whole experience! Loved it and will be back!

Celine

Reviewed May 5, 2026Reviewed May 5, 2026

Lafayette Hotel & Club

A balcony with two chairs and a small table, overlooking a coastal area with buildings and a clear sky.

A swimming pool with lounge chairs and umbrellas, surrounded by palm trees and a multi-story building with balconies.

A modern lobby with a reception desk, seating area, and a large mirror.

Inn By The Sea La Jolla

Village of La Jolla

10/10 Excellent

My husband and I went for a little weekend getaway and the hotel was lovely. We had an ocean view room with a big balcony. It was surprisingly quiet. You can walk everywhere, we left our car parked the whole time. The hotel staff is so friendly!!

Suzanne

Reviewed July 13, 2025Reviewed July 13, 2025

Inn By The Sea La Jolla

A breakfast buffet area with a stone wall, a coffee station, and a fruit display.

A modern hotel lobby with a fireplace, comfortable seating, and a large painting of a sunset.

An elevator area with stone walls and a potted plant.

A table with two gold-framed lamps and a vase of white flowers.

Hampton Inn San Diego-Kearny Mesa

Kearny Mesa

10/10 Excellent

I loved that our rooms were cleaned daily, beds made, bathrooms spotless, and we got fresh towels daily. The room was spacious, clean, and efficient.

Julie

Reviewed October 24, 2023Reviewed October 24, 2023

Hampton Inn San Diego-Kearny Mesa

An outdoor seating area with a fire feature, white chairs, and potted plants.

A modern lounge area with a pool view, comfortable seating, and a large window.

A modern hotel with a prominent signage for Springhill Suites Marriott.

A reception area with a modern design, including a reception desk, a refrigerator stocked with beverages, and a wall with a green leaf pattern.

Springhill Suites San Diego Mission Valley

Mission Valley

10/10 Excellent

Really nice room. Spacious. Nice set up. Comfy beds. Fridge and microwave. Pool. Decent hotel breakfast

Brittany

Reviewed June 18, 2024Reviewed June 18, 2024

Springhill Suites San Diego Mission Valley

A hotel entrance with a stone archway, a reception desk, and potted plants.

An outdoor patio area with tables and chairs, potted plants, and umbrellas.

A buffet with various food items, including omelets and baked goods, in stainless steel containers.

A Holiday Inn Express hotel with a clear entrance, a parking lot, and a landscaped area with plants.

Holiday Inn Express San Diego Airport - Old Town by IHG

Mission Hills

10/10 Excellent

Loved the shuttle service to Old Town. We’ve stayed there before and didn’t have that option. It was so convenient to have the shuttle service. Driver was super friendly.

Angela

Reviewed April 21, 2025Reviewed April 21, 2025

Holiday Inn Express San Diego Airport - Old Town by IHG

A spacious lobby with modern furniture, large windows, and a high ceiling with hanging lights.

A pathway leading to a building labeled "LEGACY Hotel."

A modern interior with wooden panel ceilings, patterned seating, and a central bar area.

A hotel room with a large bed, a wooden nightstand, a bench, a desk with a TV, and a chair.

Legacy Resort Hotel & Spa

Mission Valley

10/10 Excellent

Beautiful design. Very clean. Great location with easy access to highways to all parts of the city. Lots of shopping & food options nearby. Friendly staff.

Sirma

Reviewed January 12, 2024Reviewed January 12, 2024

Legacy Resort Hotel & Spa

A living room with a sectional sofa, a wooden coffee table, a blue ottoman, a wooden chair with cushions, a built-in bookshelf, and a stone wall with a fireplace.

A hotel lobby with a snack bar, seating area, and a sign indicating amenities like elevators, meeting rooms, and a pool.

A hotel lobby with a stone wall, a fireplace, a sectional sofa, a coffee table, and a reception desk.

A long buffet counter with multiple coffee dispensers, a fruit bowl, and a variety of food items.

Country Inn & Suites by Radisson, San Diego North, CA

Sorrento Valley

10/10 Excellent

Hotel was clean and conveniently located near restaurants and such.

Lynette

Reviewed October 24, 2025Reviewed October 24, 2025

Country Inn & Suites by Radisson, San Diego North, CA

An outdoor patio with wicker furniture, a grill, and string lights.

A modern hotel lobby with a central dining area, seating arrangements, and a large window providing natural light.

A modern living room with a sofa, chairs, and pendant lighting.

TownePlace Suites by Marriott San Diego Central

Kearny Mesa

10/10 Excellent

comfortable room with amenities including a kitchenette and full fridge. It was nice to have free hot/cold breakfast items to eat. Smaller property = less crowds/ less busy. The staff were friendly and nice. The area is quiet and away from busy streets. There were plenty of restaurant within a driving distance.

Andrew

Reviewed March 11, 2020Reviewed March 11, 2020

TownePlace Suites by Marriott San Diego Central

An outdoor patio with a fire feature, seating, and string lights.

A beach with clear skies, a rocky cliff, and a lighthouse in the distance.

A multi-level hotel lobby with dining areas, a reception desk, and a large TV screen.

A swimming pool with a visible water filtration system and a tiled edge.

Embassy Suites by Hilton San Diego La Jolla

University City

10/10 Excellent

We loved the place and definitely I will stay again

Imelda

Reviewed November 15, 2024Reviewed November 15, 2024

Embassy Suites by Hilton San Diego La Jolla

A modern bar area with wooden ceiling beams, bar stools, and a long counter.

An outdoor seating area with wicker chairs and a fire feature.

A multi-story hotel with a curved facade, balconies, and a central entrance with a glass door.

A hotel with a swimming pool, outdoor seating, and a courtyard.

Courtyard by Marriott San Diego Central

Kearny Mesa

10/10 Excellent

Staff was courteous and very helpful.

John

Reviewed July 26, 2025Reviewed July 26, 2025

Courtyard by Marriott San Diego Central

A swimming pool with lounge chairs and a waterfall feature, surrounded by palm trees and a building with multiple balconies.

A modern outdoor seating area with a wooden wall, a hanging chair, and a large potted plant.

A modern hotel with a prominent tower, multiple floors, and a well-lit entrance.

A modern lobby with a round table and four chairs, a reception desk, and a large window.

San Diego Marriott Mission Valley

Mission Valley

10/10 Excellent

Front desk personnel were awesome. Arrived earlier than expected but they were able to make some adjustments and got us in a room immediately!! Bathroom was very clean along with our bedroom area. Wife appreciates that😊

Russell

Reviewed June 3, 2024Reviewed June 3, 2024

San Diego Marriott Mission Valley

An outdoor seating area with a sofa, two tables, and a fire feature.

A spacious outdoor area with a pool, wooden furniture, and a view of the city.

A spacious indoor area with wooden tables and chairs, a high ceiling with wooden beams, and a view of the outside through large windows.

A lobby with wooden furniture, a fire feature, and multiple screens displaying content.

Holiday Inn Express & Suites San Diego - Mission Valley by IHG

Mission Valley

10/10 Excellent

MK was very nice in helping my family and I have a smooth check in on July 27th.

Angela

Reviewed July 28, 2025Reviewed July 28, 2025

Holiday Inn Express & Suites San Diego - Mission Valley by IHG

An outdoor seating area with fire pits, lounge chairs, and a modern building in the background.

A hotel lobby with a modern design, featuring a reception desk, seating area, and a large glass wall.

A spacious dining area with high ceilings, modern furniture, and large windows allowing natural light.

A multi-story hotel with a modern design, featuring a prominent 'Homewood Suites' sign.

Homewood Suites by Hilton San Diego Hotel Circle/SeaWorld Area

Mission Valley

10/10 Excellent

Staff was wonderful. Enjoyed our stay. Room was awesome. I picked a winner. Enjoyed the breakfast.

Rosemary

Reviewed November 17, 2024Reviewed November 17, 2024

Homewood Suites by Hilton San Diego Hotel Circle/SeaWorld Area

A patio area with a circular fire pit surrounded by wicker furniture and a stone wall.

A modern bar area with a marble countertop, wooden stools, and a unique hanging light fixture.

A modern hotel lobby with a sofa, armchairs, a coffee bar, and a TV.

A multi-story hotel with balconies, palm trees, and a well-lit pathway.

Courtyard by Marriott San Diego Sorrento Valley

Sorrento Valley

10/10 Excellent

Everything was great! Clean n quiet n I really like the location/area. We would definitely stay here again!

Arlayna

Reviewed July 21, 2023Reviewed July 21, 2023

Courtyard by Marriott San Diego Sorrento Valley

A buffet setup with various food items in metal containers, a patterned wall, and a counter with amenities.

A modern hotel room with a blue sofa, a small table, and a lamp. There are two framed artworks on the wall and a wooden door in the background.

A reception area with a modern design, featuring a reception desk, a blue wall with geometric patterns, and a wooden accent wall.

Holiday Inn Express Hotel & Suites San Diego-Sorrento Valley by IHG

Sorrento Valley

10/10 Excellent

Clean, quiet, good for family

Ga Hee

Reviewed December 11, 2024Reviewed December 11, 2024

Holiday Inn Express Hotel & Suites San Diego-Sorrento Valley by IHG

A spacious lobby with a central seating area, a reception desk, and a staircase leading to an upper level.

A hotel room with two beds, a desk, and a large window offering a view of the landscape.

A Courtyard by Marriott hotel with a central courtyard, palm trees, and a fountain.

A hotel lobby with a flat-screen TV mounted on a wooden panel, two sofas with yellow cushions, a small round table, and two floor lamps.

Courtyard by Marriott San Diego Miramar

Miramar

10/10 Excellent

Staff was excellent Room was good Pool not so much

Anonymous traveler

Reviewed April 30, 2019Reviewed April 30, 2019

Courtyard by Marriott San Diego Miramar

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Search Vacation Homes in Central San Diego

Change your mind

Treat yourself

Be picky

Find vacation rentals that suit your style

Check prices for these dates

Learn more about Central San Diego

Top reviews in Central San Diego

Lafayette Hotel & Club

10/10 Excellent

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