Photo by Tonette Pineda✈⛵🚌🚉🚃🚅🚀

South San Francisco 5 Stars Hotels

Start date: Check-in selected.
To Date
End date: Check-out
  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check availability on South San Francisco 5 Star Hotels

This weekend
Next weekend

Our top choices for South San Francisco 5-star hotels

Fairmont San Francisco

Fairmont San Francisco
5.0 star property
Downtown San Francisco
9.0 out of 10, Wonderful, (1443)
"Beautiful hotel "
United States
Xandy
The price is NT$6,817
NT$9,324 total
includes taxes & fees
Jan 4 - 2026/1/5
Fairmont San Francisco

Claremont Resort & Club

Claremont Resort & Club
5.0 star property
Claremont Hills
8.8 out of 10, Excellent, (1001)
"Great hotel"
United States
Peter
The price is NT$6,909
NT$9,827 total
includes taxes & fees
Jan 8 - 2026/1/9
Claremont Resort & Club

Palace Hotel, a Luxury Collection Hotel, San Francisco

Palace Hotel, a Luxury Collection Hotel, San Francisco
5.0 star property
Downtown San Francisco
9.2 out of 10, Wonderful, (1004)
"Just a spectacular place to stay! Beautifully appointed. All staff were very friendly and accommodating We will definitely be back!"
United States
Mandana
The price is NT$8,021
NT$9,441 total
includes taxes & fees
Jan 2 - 2026/1/3
Palace Hotel, a Luxury Collection Hotel, San Francisco

Taj Campton Place

Taj Campton Place
5.0 star property
Union Square
9.2 out of 10, Wonderful, (1003)
"Wonderful Staff and hospitality."
United States
Rachel
The price is NT$5,618
NT$7,702 total
includes taxes & fees
Jan 1 - 2026/1/2
Taj Campton Place

Four Seasons Hotel San Francisco

Four Seasons Hotel San Francisco
5.0 star property
Downtown San Francisco
9.4 out of 10, Exceptional, (1005)
"The staff is fantastic"
United States
Brandon
The price is NT$12,151
NT$14,301 total
includes taxes & fees
Jan 4 - 2026/1/5
Four Seasons Hotel San Francisco

The Ritz-Carlton, San Francisco

The Ritz-Carlton, San Francisco
5.0 star property
Downtown San Francisco
9.4 out of 10, Exceptional, (1004)
"The hotel is really first class. Very clean, and a great staff. Loved it. Great location. "
United States
Carol
The price is NT$10,155
NT$13,479 total
includes taxes & fees
Jan 3 - 2026/1/4
The Ritz-Carlton, San Francisco

1 Hotel San Francisco

1 Hotel San Francisco
5.0 star property
Downtown San Francisco
9.2 out of 10, Wonderful, (487)
"The staff was incredible and we loved all of the design touches in the room. The attention to detail was impressive. "
United States
Eric
The price is NT$11,507
NT$15,326 total
includes taxes & fees
Jan 3 - 2026/1/4
1 Hotel San Francisco

Four Seasons Hotel San Francisco at Embarcadero

Four Seasons Hotel San Francisco at Embarcadero
5.0 star property
Downtown San Francisco
9.6 out of 10, Exceptional, (1001)
"The views are jaw dropping. The service is excellent in all areas, particularly broom service. Very easy to park and car service to local locations. "
United States
stephanie
The price is NT$13,256
NT$15,602 total
includes taxes & fees
Jan 8 - 2026/1/9
Four Seasons Hotel San Francisco at Embarcadero

The St. Regis San Francisco

The St. Regis San Francisco
5.0 star property
Downtown San Francisco
9.4 out of 10, Exceptional, (696)
"Impeccable service; nice room, overall great experience"
United States
Karla
The price is NT$11,141
NT$14,550 total
includes taxes & fees
Dec 26 - Dec 27
The St. Regis San Francisco

The Ritz-Carlton, Half Moon Bay

The Ritz-Carlton, Half Moon Bay
5.0 star property
Ocean Colony
9.0 out of 10, Wonderful, (647)
"The staff throughout the resort were extremely friendly and helpful."
United States
Steve
The price is NT$24,923
NT$31,537 total
includes taxes & fees
Jan 20 - 2026/1/21
The Ritz-Carlton, Half Moon Bay

Four Seasons Hotel Silicon Valley at East Palo Alto

Four Seasons Hotel Silicon Valley at East Palo Alto
5.0 star property
East Palo Alto
9.4 out of 10, Exceptional, (666)
"Wonderful stay "
United States
Cindy
The price is NT$11,362
NT$12,918 total
includes taxes & fees
Jan 2 - 2026/1/3
Four Seasons Hotel Silicon Valley at East Palo Alto

Rosewood Sand Hill

Rosewood Sand Hill
5.0 star property
Menlo Park
9.4 out of 10, Exceptional, (276)
"Really great hotel and my go to place for anything in Palo Alto "
United States
Lisa
The price is NT$25,423
NT$31,766 total
includes taxes & fees
Jan 16 - 2026/1/17
Rosewood Sand Hill

Nobu Hotel Palo Alto

Nobu Hotel Palo Alto
5.0 star property
University South
9.2 out of 10, Wonderful, (434)
"Beautiful hotel. "
United States
Dianne
The price is NT$12,467
NT$14,424 total
includes taxes & fees
Dec 28 - Dec 29
Nobu Hotel Palo Alto

Hotel Drisco

Hotel Drisco
5.0 star property
Pacific Heights
9.8 out of 10, Exceptional, (455)
"The breakfast was amazing, lots of variety including hot items cooked freshly"
United Kingdom
Julie Ann
The price is NT$17,015
NT$19,791 total
includes taxes & fees
Jan 4 - 2026/1/5
Hotel Drisco

Fairmont Heritage Place, Ghirardelli Square

Fairmont Heritage Place, Ghirardelli Square
5.0 star property
Fisherman's Wharf
9.4 out of 10, Exceptional, (386)
"Great staff, clean, excellent location, spacious rooms"
United States
Christopher
The price is NT$25,534
NT$30,002 total
includes taxes & fees
Jan 4 - 2026/1/5
Fairmont Heritage Place, Ghirardelli Square

Neighbourgood Sutter Mansion

Neighbourgood Sutter Mansion
5.0 star property
Western Addition
9.4 out of 10, Exceptional, (228)
"The Sutter Mansion is gorgeous, historic and filled with original artwork. The bed was very comfortable. We had a few issues which were quickly rectified. Service is extraordinary."
United States
Jananne
The price is NT$8,920
NT$10,392 total
includes taxes & fees
Dec 25 - Dec 26
Neighbourgood Sutter Mansion

Dimond Abode Vacation Rental 3428

Dimond Abode Vacation Rental 3428
5.0 star property
Dimond
9.4 out of 10, Exceptional, (6)
"Great place, great customer service!"
United States
Anonymous traveler
Dimond Abode Vacation Rental 3428

Dimond Abode Vacation Rental

Dimond Abode Vacation Rental
5.0 star property
Dimond
10.0 out of 10, Exceptional, (1)
"The unit was extremely clean and having access to a garage was definitely a plus for our stay! Nice touches, especially coffee / tea , snacks, and a well equipped kitchen made us feel welcomed the minute we stepped through the door. A+"
United States
Camille
Dimond Abode Vacation Rental
Save an average of 15% on thousands of hotels when you're signed in

Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in South San Francisco.
Still don't see what you're looking for?
See all properties in South San Francisco.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about South San Francisco

Perched on the edge of San Francisco Bay, this family-friendly city boasts a surprising castle and stunning mountain views. Foodies flock to local restaurants, while thrill-seekers race go-karts at K1 Speed or tour the famous See's Candies factory.

#BVSBlue Aristodes Demetries, One Of Americas Best Known Sculptors Created This Steel Sculpture As A Symbol Of Cabot Cabot And Forbes Industrial Park. Situated 243 Feet Above Sea Level It Rises To A Be Seen From The Bay Bridge, The East Bay and SFO. Called The Wind Harp Locally. It emits eerie sounds when the wind 💨is at its strongest.
Photo by Tonette Pineda✈⛵🚌🚉🚃🚅🚀
Open Photo by Tonette Pineda✈⛵🚌🚉🚃🚅🚀

Top South San Francisco Hotel Reviews

Frequently asked questions

What are the best 5-star hotels in South San Francisco?
According to Expedia customer reviews, The St. Regis San Francisco, Four Seasons Hotel San Francisco and Mansion on Sutter are some of the most popular 5-star hotels in South San Francisco. Featuring top-of-the-line amenities and unparalleled service, you'll enjoy a luxurious and memorable stay.
How much does it cost to stay in a 5-star hotel in South San Francisco?
There are a range of pricing options for a 5-star hotel in South San Francisco on Expedia. How much you'll pay will depend on when you travel, length of your trip and other factors. Compare available properties for your preferred dates and use our pricing and other filters to lock in the ideal luxury stay.

  • Search for the lowest price per night from NT$4,079

What makes a hotel 5 stars in South San Francisco?
From high-end restaurants and fitness centers to swimming pools and dreamy bedding, the 5-star experience in South San Francisco is all about comfort and luxury. But it calls for more than just upscale amenities to receive a 5-star rating. Stays must also offer exceptional services like in-room massages, laundry and dry cleaning and a nightly turn-down service.

Explore a world of travel with Expedia