A large suspension bridge, industrial cranes, and a calm river.

Panama Canal Zone 5 Stars Hotels

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Panama Canal Zone 5 Star Hotels

Tonight
Sep 15 - Sep 16
Tomorrow
Sep 16 - Sep 17
This weekend
Sep 18 - Sep 20
Next weekend
Sep 25 - Sep 27

Our top choices for Panama Canal Zone 5-star hotels

A rooftop pool with sun loungers and umbrellas, surrounded by palm trees and modern buildings.
A modern hotel room with a dining area, a TV, and a city view.
A modern living room with a sofa set, a coffee table, and a dining area with chairs and a table.
A spacious lobby with a central seating area, a chandelier, and a modern ceiling design.

1. Hotel Riu Plaza Panama

Hotel Riu Plaza Panama
Bella Vista
United States
Lori
NT$4,374
NT$4,811 total
includes taxes & fees
Sep 27 - Sep 28
Hotel Riu Plaza Panama
A person seated at a bar with a drink, in a room with a teal accent wall and hanging lights.
A modern interior with a decorative ceiling, a person in a white dress, and a blue-lit wall.
An outdoor seating area with wicker chairs and tables, large windows offering a city view at dusk.
A modern building with a rooftop lounge area, large windows, and a balcony overlooking a cityscape.

2. Waldorf Astoria Panama

Waldorf Astoria Panama
Bella Vista
United States
Aysha
NT$8,075
NT$8,883 total
includes taxes & fees
Oct 3 - Oct 4
Waldorf Astoria Panama
A poolside area with lounge chairs and a view of the ocean.
A modern building with a symmetrical facade, multiple balconies, and a central atrium with lighting.
A modern bathroom with a large bathtub, two sinks, and a glass-enclosed shower area with a city view.
A terrace with seating and a view of the ocean.

3. JW Marriott Panama

JW Marriott Panama
San Francisco
United States
Benjamin A
NT$8,109
NT$8,920 total
includes taxes & fees
Oct 3 - Oct 4
JW Marriott Panama
A modern hotel room with a sofa, a coffee table, a TV mounted on the wall, and a dining area with a table and chairs.
A modern lobby with a staircase, marble flooring, and large windows with tropical plants.
An indoor swimming pool with lounge chairs and red chairs, surrounded by lush greenery and a modern interior design.
The exterior of the Renaissance Hotel with a modern design, featuring a prominent 'R' logo, a geometric ceiling design, and a well-lit entrance area.

4. Renaissance Panama City Hotel

Renaissance Panama City Hotel
Bella Vista
United States
Carlos
NT$4,290
NT$4,719 total
includes taxes & fees
Oct 11 - Oct 12
Renaissance Panama City Hotel
A balcony with a table, chairs, and a view of a city skyline across a body of water.
A spacious lobby with high ceilings, modern furniture, and decorative lighting fixtures.
A spacious lobby with a round coffee table, seating areas, and a large wall clock.
A hotel with a rooftop pool, lounge chairs, and a view of the sea.

5. Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City
Casco Viejo
United States
Jose
NT$11,010
NT$12,111 total
includes taxes & fees
Sep 18 - Sep 19
Sofitel Legend Casco Viejo, Panama City
A pool area with lounge chairs and umbrellas, surrounded by greenery and a multi-story building in the background.
A spacious lobby with a curved ceiling, a central staircase, and a reception desk.
A modern interior with a central seating area, potted plants, and a staircase.
A spacious hotel lobby with modern furniture, large windows, and a city view.

6. Hyatt Regency Panama City

Hyatt Regency Panama City
Bella Vista
United States
Abraham
NT$5,942
NT$6,536 total
includes taxes & fees
Sep 26 - Sep 27
Hyatt Regency Panama City
A hotel entrance with a central water feature, seating areas, and potted plants.
A pool with a central water feature, surrounded by seating areas and potted plants.
The entrance of The Santa Maria with a covered walkway and a view of the interior.
An outdoor dining area with wicker chairs and tables, a bar with bottles, and a pool in the background.

7. The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
Juan Diaz
United States
PAULA
NT$8,317
NT$9,149 total
includes taxes & fees
Sep 18 - Sep 19
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
A modern restaurant with large windows offering a city view, warm lighting, and contemporary furniture.
A modern living room with a city view, featuring a purple accent wall, a white sofa, and a glass table.
A modern hotel room with a large bed, a desk, a chair, and a view of the cityscape.
A high-rise building with a rooftop pool area, surrounded by other buildings.

8. W Panama

W Panama
Bella Vista
United States
Nikkia
NT$7,092
NT$7,802 total
includes taxes & fees
Oct 11 - Oct 12
W Panama
A modern hotel pool area with lounge chairs and a clear view of the ocean.
A modern bar area with seating and a view of the city.
A spacious lobby with a large seating area, a glass display case with bottles, and a view of the city at night.
A marina with boats docked, a city skyline with illuminated buildings, and a visible moon in the sky.

9. Hilton Panama

Hilton Panama
Bella Vista
United States
Kevin
NT$7,530
NT$8,283 total
includes taxes & fees
Oct 10 - Oct 11
Hilton Panama
A hotel with a pool, beach, and palm trees.
A large hotel with multiple towers, a central courtyard with a swimming pool, and surrounding landscaped areas.
A spacious lobby with a large seating area, a reception desk, and large windows offering a view of the ocean and palm trees.
A beachfront hotel with a large building, a beach, and a clear sky.

10. The Westin Playa Bonita Panama

The Westin Playa Bonita Panama
Veracruz
Canada
Flavio
NT$6,549
NT$7,204 total
includes taxes & fees
Sep 28 - Sep 29
The Westin Playa Bonita Panama
A modern living room with a sofa, round black ottomans, and a vase of flowers. A cityscape is visible through the window.
A cozy outdoor seating area with a wooden bench and white tables, surrounded by lush greenery and potted plants.
A rooftop swimming pool with a cityscape view, glass railings, and a modern architectural design.
A bar area with a long counter, multiple bar stools, and a television screen. There are large windows providing natural light and a view of the outdoors.

11. Bristol Panama, a Registry Collection Hotel

Bristol Panama, a Registry Collection Hotel
Bella Vista
United States
Juliet
NT$6,725
NT$7,398 total
includes taxes & fees
Sep 20 - Sep 21
Bristol Panama, a Registry Collection Hotel
A hotel room with two beds, a desk, a chair, a mirror, and a large window.
A rooftop pool with lounge chairs and a city skyline in the background.

12. Waymore Hotel Spa and Casino

Waymore Hotel Spa and Casino
Bella Vista
United States
Aldo
NT$3,507
NT$3,858 total
includes taxes & fees
Sep 17 - Sep 18
Waymore Hotel Spa and Casino

13. Megapolis Hotel Panamá

Megapolis Hotel Panamá
San Francisco
United States
MARVIN
NT$7,497
NT$8,247 total
includes taxes & fees
Oct 17 - Oct 18
Megapolis Hotel Panamá
Save an average of 15% on thousands of hotels when you're signed in

Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Panama Canal Zone.
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

Ave. Domingo Diaz Tocumen Panama
NT$3,888
NT$4,487 total
Oct 12 - Oct 13
includes taxes & fees
8.6/10 Excellent! (2,721 reviews)
Crowne Plaza Panama Airport by IHG
Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

Plaza de la Independencia Casco Viejo Panama City Panama
NT$5,845
NT$6,430 total
Oct 17 - Oct 18
includes taxes & fees
Central Hotel Panama Casco Viejo
Hotel El Panama by Faranda Grand, a member of Radisson Individuals

Hotel El Panama by Faranda Grand, a member of Radisson Individuals

Via Espana 111 Panama City Panama
NT$3,045
NT$3,349 total
Sep 29 - Sep 30
includes taxes & fees
Hotel El Panama by Faranda Grand, a member of Radisson Individuals
Still don't see what you're looking for?
See all properties in Panama Canal Zone.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Panama Canal Zone

Explore the relaxing area of Panama Canal Zone—natural beauty, golf courses, and popular sights like Albrook Shopping Mall.

See all hotels in Panama Canal Zone
A large suspension bridge, industrial cranes, and a calm river.

Top Panama Canal Zone Hotel Reviews

Frequently asked questions

How much does it cost to stay in a 5-star hotel in Panama Canal Zone?
The amount you pay for a 5-star hotel in Panama Canal Zone depends on things like when you plan to go and the length of your vacation. Our insider tip for bagging an awesome deal? Use our pricing filters to compare all of the available accommodations for your selected dates.
  • Search for the lowest price per night from NT$3,349
What makes a hotel 5 stars in Panama Canal Zone?
In Panama Canal Zone, a hotel must offer a specific number of upscale features to earn 5 stars. These may include gourmet restaurants, saunas and spas, on-site gyms, premium bedding, complimentary luxury toiletries and more. What also sets 5-star hotels apart is their exceptional standard of service. You'll enjoy things like concierge services, nightly turn-down services and in-room massage. Some may even offer extra touches such as a welcome gift.
Are there any 5-star all-inclusive resorts in Panama Canal Zone?
Expedia's filters are the quickest way to narrow down what you're looking for. Check the "All inclusive" and "5-star" boxes to see the most luxurious hotels in Panama Canal Zone where your meals, room, entertainment and activities are included in the price. At these getaways, your vacation is pure extravagance from the moment you check in.