De Soto 4 Stars Hotels
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Compare De Soto 4 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.
Our top choices for De Soto 4-star hotels

Walker's Bluff Casino Resort
Walker's Bluff Casino Resort
9.4 out of 10, Exceptional, (366)
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Explore a world of travel with Expedia
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De Soto Hotels by Star Rating
Stay near popular De Soto attractions
- Hotels near Shawnee National Forest
- Hotels near Mississippi River
- Hotels near Southern Illinois University
- Hotels near Giant City State Park
- Hotels near DuQuoin State Fairgrounds
- Hotels near Marion Cultural and Civic Center
- Hotels near I-57 Drag Strip
- Hotels near Blue Sky Vineyards
- Hotels near John A. Logan College
- Hotels near Williamson County Fairgrounds
- Hotels near Memorial Hospital of Carbondale
- Hotels near Kokopelli Golf Club
- Hotels near Stone Creek Golf Club and Resort
- Hotels near Crab Orchard Golf Club
- Hotels near Heartland Regional Medical Center
- Hotels near Lake Murphysboro State Park
- Hotels near Pomona Winery
- Hotels near Pyramid State Recreation Area
- Hotels near Marion Stadium
- Hotels near Owl Creek Vineyard
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