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Compare 1,680 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Outdoor pool, open 7:00 AM to 10:30 PM, free cabanas, pool umbrellas
Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino

4.0 star property
Tocumen
8.6 out of 10, Excellent, (1857)
"I love the included shuttle and breakfast and how close it is to the airport"
United States
leon
The price is NT$3,906
NT$4,297 total
includes taxes & fees
Dec 15 - Dec 16
Riande Aeropuerto Hotel & Casino
Outdoor pool, sun loungers
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5.0 star property
Bella Vista
9.0 out of 10, Wonderful, (4624)
"Awesome great place to stay "
United States
Herbert
The price is NT$3,416
NT$3,758 total
includes taxes & fees
Dec 21 - Dec 22
Hotel Riu Plaza Panama
Suite, 1 Bedroom, Golf View (Terrace) | Premium bedding, minibar, in-room safe, desk
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

5.0 star property
Juan Diaz
9.6 out of 10, Exceptional, (635)
"As usual the stay was amazing in this hotel"
United States
Jose
The price is NT$7,240
NT$7,964 total
includes taxes & fees
Dec 14 - Dec 15
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
Restaurant
Hyatt Regency Panama City

Hyatt Regency Panama City

4.5 star property
Bella Vista
10.0 out of 10, Exceptional, (118)
"Great hotel fair price"
United States
Santiago
The price is NT$4,217
NT$4,639 total
includes taxes & fees
Dec 20 - Dec 21
Hyatt Regency Panama City
2 outdoor pools, pool umbrellas, sun loungers
Radisson Hotel Panama Canal

Radisson Hotel Panama Canal

4.5 star property
Amador
8.6 out of 10, Excellent, (1001)
"Wonderful staff and easy checkin!"
United States
Kristin
The price is NT$2,177
NT$2,395 total
includes taxes & fees
Dec 23 - Dec 24
Radisson Hotel Panama Canal
Breakfast, lunch, dinner served; international cuisine
Courtyard by Marriott Panama Metromall

Courtyard by Marriott Panama Metromall

4.0 star property
Cerro Viento
8.8 out of 10, Excellent, (1002)
"Conveniently located near the airport and major shopping outlets."
United States
Greg
The price is NT$3,300
NT$3,630 total
includes taxes & fees
Jan 5 - 2026/1/6
Courtyard by Marriott Panama Metromall
Front of property
Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 star property
San Francisco
8.4 out of 10, Very Good, (1252)
"Its a very beautiful hotel with view and very good breakfast "
United States
Patrick
The price is NT$3,828
NT$4,211 total
includes taxes & fees
Dec 19 - Dec 20
Megapolis Hotel Panamá
Outdoor pool, pool umbrellas, sun loungers
Ramada Plaza by Wyndham Panama Punta Pacifica

Ramada Plaza by Wyndham Panama Punta Pacifica

4.0 star property
San Francisco
9.6 out of 10, Exceptional, (1099)
"Property and location was excellent. Staff is very accommodating and helpful. "
Canada
Helen
The price is NT$3,797
NT$4,177 total
includes taxes & fees
Jan 4 - 2026/1/5
Ramada Plaza by Wyndham Panama Punta Pacifica
50-inch LED TV with satellite channels
Arcadia Condo Suites

Arcadia Condo Suites

2.5 star property
Costa del Este
9.4 out of 10, Exceptional, (153)
"Everything was great, helpful staff, great room , clean, excellent service!"
United States
Gregory Walter
The price is NT$1,968
NT$3,608 total
includes taxes & fees
Dec 15 - Dec 16
Arcadia Condo Suites
3 outdoor pools, pool umbrellas, sun loungers
The Westin Playa Bonita Panama

The Westin Playa Bonita Panama

5.0 star property
Veracruz
8.0 out of 10, Very Good, (1002)
"Clean rooms , friendly staff , had great experience "
United States
Saro
The price is NT$5,471
NT$6,018 total
includes taxes & fees
Dec 18 - Dec 19
The Westin Playa Bonita Panama
2 bars/lounges, gastropub
Riande Urban Hotel

Riande Urban Hotel

3.5 star property
Bella Vista
8.8 out of 10, Excellent, (1052)
"Good hotel and nice staff"
United States
Jose
The price is NT$2,249
NT$2,474 total
includes taxes & fees
Jan 4 - 2026/1/5
Riande Urban Hotel
Front of property - evening/night
Principe Hotel and Suites

Principe Hotel and Suites

3.0 star property
Bella Vista
9.0 out of 10, Wonderful, (1581)
"Great hotel, location, food. Highly recommend the sushi restaurant next door.. One of the best ever. "
United States
Lakshmin
The price is NT$1,562
NT$1,718 total
includes taxes & fees
Dec 20 - Dec 21
Principe Hotel and Suites
Living area
Magnolia Inn

Magnolia Inn

2.0 star property
Casco Viejo
8.8 out of 10, Excellent, (409)
"Excelent location , friendly staff and cute hotel"
Canada
Renata
The price is NT$1,714
NT$1,885 total
includes taxes & fees
Dec 7 - Dec 8
Magnolia Inn
Exterior
Hotel Milan

Hotel Milan

3.0 star property
Bella Vista
9.0 out of 10, Wonderful, (423)
"It was a very pleasant experience the hotel is located in a great neighborhood, staff were friendly and competent, secure property and parking, clean and decent accommodations, especially at the room price point. "
Canada
Roger
The price is NT$1,250
NT$1,375 total
includes taxes & fees
Dec 9 - Dec 10
Hotel Milan
Terrace/patio
Sheraton Grand Panama

Sheraton Grand Panama

4.0 star property
San Francisco
8.6 out of 10, Excellent, (988)
"Was amazing food was delicious and stay was great "
United States
Amanda
The price is NT$4,217
NT$4,639 total
includes taxes & fees
Dec 14 - Dec 15
Sheraton Grand Panama
4 outdoor pools, free cabanas, pool umbrellas
JW Marriott Panama

JW Marriott Panama

5.0 star property
San Francisco
9.0 out of 10, Wonderful, (1004)
"Bedroom was very comfy, also the staff were very on point. I will definitely recommend this hotel and there services, there is so much to do at this hotel."
United States
Sarran
The price is NT$7,862
NT$8,648 total
includes taxes & fees
Jan 4 - 2026/1/5
JW Marriott Panama
Outdoor pool, open 9:00 AM to 9:00 PM, sun loungers
Hospedium Princess Hotel Panama

Hospedium Princess Hotel Panama

3.5 star property
Bella Vista
7.6 out of 10, Good, (689)
"The breakfast was great, I love the pool."
United States
Estefani
The price is NT$1,732
NT$1,905 total
includes taxes & fees
Dec 21 - Dec 22
Hospedium Princess Hotel Panama
Exterior
Decapolis Hotel Panama City

Decapolis Hotel Panama City

4.0 star property
San Francisco
8.6 out of 10, Excellent, (1430)
"Excellent stay. Wonderful staff, good location and excellent breakfast"
United States
Michael
The price is NT$2,378
NT$2,616 total
includes taxes & fees
Dec 14 - Dec 15
Decapolis Hotel Panama City
Exterior
Hotel El Panama by Faranda Grand, a member of Radisson Individuals

Hotel El Panama by Faranda Grand, a member of Radisson Individuals

4.0 star property
Bella Vista
7.8 out of 10, Good, (1004)
"Great service and staff. "
United States
Roberto
The price is NT$2,812
NT$3,093 total
includes taxes & fees
Dec 13 - Dec 14
Hotel El Panama by Faranda Grand, a member of Radisson Individuals
Front of property
MARINN Tropical Vibes Hotel

MARINN Tropical Vibes Hotel

3.5 star property
Amador
8.2 out of 10, Very Good, (181)
"Great location "
United States
itzel
The price is NT$1,924
NT$2,117 total
includes taxes & fees
Dec 7 - Dec 8
MARINN Tropical Vibes Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Santa Clara attractions

Culebra Cut

You can find out about the history of Santa Clara with a visit to Culebra Cut. Check out the casinos and top-notch restaurants in this walkable area.
See properties

Learn more about Santa Clara

Santa Clara awaits: its natural setting, monuments, history, and more!

See all hotels in Santa Clara
Adobe

Top Santa Clara Hotel Reviews

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

10/10 Excellent
"Very good breakfast and very nice hotel and close to lots of restaurants "
Michele 4-night trip
Posted 9 hours ago
Hotel Riu Plaza Panama

More cheap stays in Santa Clara

Arcadia Condo Suites

Arcadia Condo Suites

Calle rio mar Panama City Panamá Province
The price is NT$1,968 per night from Dec 15 to Dec 16
NT$1,968
NT$3,608 total
Dec 15 - Dec 16
includes taxes & fees
9.4/10 Exceptional! (150 reviews)

Frequently asked questions

What's the best place for a stay in Santa Clara?
Located 15.8 mi (25.5 km) from the heart of Santa Clara, Hotel Riu Plaza Panama is a top choice for your stay based on our traveler data. Two other choices for your stay in the area are Las Americas Golden Tower Panama and Waldorf Astoria Panama. See all available top hotels, or vacation rentals in Santa Clara.
If I need to cancel my hotel reservation in Santa Clara, will I receive a refund?
Yes! The majority of hotel bookings are fully refundable if cancelled before the hotel's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, you might be able to still cancel and get a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in Santa Clara.
Where can I learn more about changing or cancelling my trip to Santa Clara?
To access more information about rescheduling or cancelling your trip to Santa Clara, go to https://www.expedia.com/service/.
What's the best place to stay near Culebra Cut?
Gamboa Rainforest Reserve is one of the top choices for your stay based on our traveler data, and this 3.5-star hotel offers a marina and a full-service spa. It's located 2.9 mi (4.7 km) from Culebra Cut. Other good options within 5 miles include Canopy Bed & Breakfast and Casa en Gamboa al lado Canal de Panama.
What is staying in Santa Clara like?
Visitors can enjoy all that Santa Clara has to offer including its monuments. A top sight in the area is Albrook Shopping Mall. There are 1611 hotels and other accommodations in the surrounding area. Find out more about Santa Clara.
What is there to see in Santa Clara?
A favorite place to visit is Culebra Cut. Additionally, you'll find Albrook Shopping Mall in the area. Check out what more to see and do in Expedia's Santa Clara guide.
What's the seasonal weather like in Santa Clara?
The hottest months are usually April and March with an average temp of 79°F, while the coldest months are January and February with an average of 78°F. The rainiest months in Santa Clara are July, August, November, and October, with each month seeing an average of 11 inches of rainfall.

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