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Top Romantic Southeast Minnesota Hotels

Alexander Mansion Bed and Breakfast

274 East Broadway Winona MN

2 hours drive from Mayo Clinic

Enjoy a stay at this romantic bed & breakfast, featuring a garden and a terrace for couples to enjoy.

10/10 Exceptional! (370 reviews)

Room great. Staff great. Guests all had nice conversations at breakfast which was also great. History of house was very interesting.

Reviewed on 2026/1/31

St James Hotel, a Historic Hotel of America

406 Main St. Red Wing MN

2 hours drive from Mayo Clinic

If you and your special someone are ready for a getaway, you're sure to love the spa and garden at this historic hotel. You'll also appreciate the luxury bedding, ...

9.2/10 Wonderful! (1,002 reviews)

Couples like: full-service spa, bar

Travelers say...

Alyssa, the front desk staff, was outstanding. She went above and beyond to make sure our stay was comfortable. We love the St. James Hotel for a weekend getaway!

Reviewed on 2026/2/1

AmericInn by Wyndham Austin

1700 8th St NW Austin MN

2 hours drive from Mayo Clinic

Enjoy a stay at this romantic hotel, featuring a hot tub and a lobby fireplace for couples to enjoy.

8.8/10 Excellent! (728 reviews)

Clean room, staff was great!

Reviewed on 2026/1/30

See all 939 properties in Southeast Minnesota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.