Photo by Southernmost Illinois Tourism Bureau

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Top Pet-friendly Southwest Illinois Hotels

La Quinta Inn & Suites by Wyndham O'Fallon, IL - St. Louis

136 Regency Park O'Fallon IL

3 hours drive from Southern Illinois University

This pet-friendly hotel welcomes dogs and cats (fees apply).

5.8/10 (1,000 reviews)

"It was dated it felt dirty, our drawer with the television on top had a collapsed, broken splinter side I wouldn’t ever stay there again"

Reviewed on 2026/6/25

Red Roof Inn St Louis - Troy, IL

2030 Formosa Road Troy IL

3 hours drive from Southern Illinois University

Make it a pet-friendly trip and bring along your four-legged friend. Dogs and cats are welcome (fees apply) at this city-center hotel.

7.8/10 Good! (1,003 reviews)

"We've stayed here a number of times when visiting friends in the area. The staff is very friendly and accommodating. There is no cost for our little French Bulldog. We recently had a room reserved for three days. The morning after our first night there, we received a call regarding an end of life ..."

Reviewed on 2026/7/3

La Quinta Inn & Suites by Wyndham Collinsville - St. Louis

6 Gateway Dr Collinsville IL

3 hours drive from Southern Illinois University

Make it a pet-friendly trip and bring along your four-legged friend. Dogs and cats are welcome (fees apply) at this city-center hotel.

7.4/10 Good! (1,000 reviews)

"The Lobby area was unkept, the breakfast area was filthy, the food was designed for children. The elevator area was dirty in all the corners, old run down flooring and walls. Needs replacement of flooring and a deep clean with a good paint job."

Reviewed on 2026/7/3

See all 761 properties in Southwest Illinois

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.