Mesopotamia Luxury Vacations 2026

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Top Luxury Mesopotamia Hotels

Hotel das Cataratas, A Belmond Hotel, Iguassu Falls

Rodovia Br 469 Km 32 Foz do Iguaçu PR

17 hours drive from Termas de Federacion

Treat yourself to a luxury stay at Hotel das Cataratas, A Belmond Hotel, Iguassu Falls, where you can enjoy amenities like 24-hour room service, free stocked ...

10/10 Exceptional! (1,012 reviews)

"If you're visiting the Brazilian side of Iguaçu, the ONLY reason not to stay here is price, as it is beyond many peoples' budgets. Otherwise, it's perfect: a gorgeous hotel in an unbeatable location directly across from the falls. We could see the falls from our room! Also, you are allowed to stay ..."

Reviewed on 2026/10/1

Iguazú Grand Hotel

Route 12 Km 1640 Puerto Iguazú Misiones

17 hours drive from Termas de Federacion

Pamper yourself with a luxury stay at Iguazú Grand Hotel, where you can enjoy amenities like Champagne service, massage services, and more. The 3 outdoor pools, ...

9.2/10 Wonderful! (684 reviews)

"Super friendly staff, beautiful property. Every amenity you want during your vacation was available."

Reviewed on 2026/9/30

Gran Melia Iguazú

Parque Nacional Iguazu Puerto Iguazú Misiones

17 hours drive from Termas de Federacion

Go for a luxurious stay at Gran Melia Iguazú, where you can enjoy amenities like massage services, Egyptian cotton sheets, and more. Deluxe amenities at this ...

9.4/10 Exceptional! (1,011 reviews)

"Exelente todo"

Reviewed on 2026/9/29

See all 523 properties in Mesopotamia

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.