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Top Luxury Mesopotamia Hotels

Hotel das Cataratas, A Belmond Hotel, Iguassu Falls

Rodovia Br 469 Km 32 Foz do Iguaçu PR

17 hours drive from Termas de Federacion

Treat yourself to a luxury stay at Hotel das Cataratas, A Belmond Hotel, Iguassu Falls, where you can enjoy amenities like 24-hour room service, free stocked ...

9.8/10 Exceptional! (1,000 reviews)

An amazing colonial style hotel - luxury from yester year

Reviewed on 2026/3/20

Iguazu Grand Resort Spa & Casino

Route 12 Km 1640 Puerto Iguazú Misiones

17 hours drive from Termas de Federacion

Pamper yourself with a luxury stay at Iguazu Grand Resort Spa & Casino, where you can enjoy amenities like Champagne service, massage services, and more. The ...

9/10 Wonderful! (638 reviews)

The hotel was perfect for what we needed! The rooms were spacious and the staff were incredible! The pool was stunning and very relaxing

Reviewed on 2026/3/22

Gran Melia Iguazú

Parque Nacional Iguazu Puerto Iguazú Misiones

17 hours drive from Termas de Federacion

Go for a luxurious stay at Gran Melia Iguazú, where you can enjoy amenities like massage services, Egyptian cotton sheets, and more. Deluxe amenities at this ...

9.2/10 Wonderful! (1,000 reviews)

Hotel com vista invrivel e uma otima estrutura , deixo ponto de atencao para uma parte da equipe que esta desmotivada , deixando a experiencia nao tao agradavel

Reviewed on 2026/3/24

See all 511 properties in Mesopotamia

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.