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Top Luxury Southeast Jacksonville Hotels

Tricove Inn & Suites

4300 Salisbury Rd Jacksonville FL

11 min drive from Mayo Clinic Florida

Pamper yourself with a luxe vacation at Tricove Inn & Suites. Notable amenities at this motel include an outdoor pool and a fitness center.

7.4/10 Good! (1,004 reviews)

"Clean room friendly staff, accessible parking..."

Reviewed on 2026/6/26

Red Roof Inn PLUS+ Jacksonville - Southpoint

6969 Lenoir Avenue E Jacksonville FL

11 min drive from Mayo Clinic Florida

Be treated to a luxury stay at Red Roof Inn PLUS+ Jacksonville - Southpoint, where you can enjoy amenities like premium channels, flat-screen TVs, and more. ...

7.6/10 Good! (1,001 reviews)

"I keep coming back to this place because of their pet friendly accommodations. Staff are great but I noticed this time that the cleanliness in the last room we stayed in was not up to par. Dirty and quite smelly."

Reviewed on 2026/6/26

Wyndham Garden Jacksonville

4660 Salisbury Road Jacksonville FL

10 min drive from Mayo Clinic Florida

Choose luxury at Wyndham Garden Jacksonville, where you can enjoy amenities like memory foam beds, premium channels, and more. The outdoor pool, beach bar, and ...

8/10 Very Good! (1,916 reviews)

"Management is terrible, found a dirty wash cloth on the shower curtain pole, toilet water running all night , AC rattling all night, draw on night stand keeps opening. Manager not there until 9:30 am , I had an early checkout and left a message from front desk for manager to call back and he never ..."

Reviewed on 2026/6/26

See all 587 properties in Southeast Jacksonville

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.