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Top Luxury Northeast Missouri Hotels

The Royal Sonesta Chase Park Plaza St. Louis

212 N Kingshighway St. Louis MO

6 min drive from St. Louis Union Station

Treat yourself to some luxurious accommodations at The Royal Sonesta Chase Park Plaza St. Louis, where you can enjoy amenities like pillowtop beds, designer ...

9/10 Wonderful! (1,001 reviews)

Dust in bathroom baseboards and on TV’s. 80 dollars for overnight parking with hotel or 40 with parking garage. Room service is convenient but a bit overpriced.

Reviewed on 2026/3/10

Ameristar Casino Resort and Spa

1 Ameristar Blvd St. Charles MO

34 min drive from St. Louis Union Station

Stay in the lap of luxury at Ameristar Casino Resort and Spa, where you can enjoy amenities like plush bedding, HDTVs, and more. Notable amenities include a ...

8.4/10 Very Good! (1,000 reviews)

Room was so spacious, and the bath tub was huge

Reviewed on 2026/3/9

The Ritz-Carlton, St. Louis

100 Carondelet Plaza St. Louis MO

13 min drive from St. Louis Union Station

Be treated to a luxury stay at The Ritz-Carlton, St. Louis, where you can enjoy amenities like plush bedding, designer toiletries, and more. The 3 bars, fitness ...

See all 2,886 properties in Northeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.