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Top Luxury Southeast Missouri Hotels

Super 8 by Wyndham Pevely

1711 Highway Z Pevely MO

3 hours drive from Mark Twain National Forest

Super 8 by Wyndham Pevely awaits for a deluxe vacation. Popular amenities include an indoor pool, a fitness center, and pool loungers.

5.6/10 (831 reviews)

Awesome

Reviewed on 2025/11/11

Motel 6 Poplar Bluff, MO

4101 Highway 67 N Poplar Bluff MO

3 hours drive from Mark Twain National Forest

Motel 6 Poplar Bluff, MO awaits for a deluxe vacation.

7.8/10 Good! (1,003 reviews)

Was on a roadtrip to Texas was a great stay nice hot water nice bed

Reviewed on 2025/11/28

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO

4 hours drive from Mark Twain National Forest

Days Inn and Suites by Wyndham Sikeston awaits for a deluxe vacation.

7.2/10 Good! (1,001 reviews)

Very nice room, staff was nice. The tv room and bathroom were cold. No heat in those rooms.

Reviewed on 2025/12/7

See all 619 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.